KEGG   Canis lupus familiaris (dog): 100855785
Entry
100855785         CDS       T01007                                 
Symbol
FPGS
Name
(RefSeq) folylpolyglutamate synthase, mitochondrial isoform X9
  KO
K01930  folylpolyglutamate synthase [EC:6.3.2.17]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00790  Folate biosynthesis
cfa01100  Metabolic pathways
cfa01240  Biosynthesis of cofactors
cfa01523  Antifolate resistance
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00790 Folate biosynthesis
    100855785 (FPGS)
 09160 Human Diseases
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    100855785 (FPGS)
Enzymes [BR:cfa01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.17  tetrahydrofolate synthase
     100855785 (FPGS)
SSDB
Motif
Pfam: Mur_ligase_M bpX5 Mur_ligase_C
Other DBs
NCBI-GeneID: 100855785
NCBI-ProteinID: XP_003639360
Ensembl: ENSCAFG00000020111
VGNC: 40973
UniProt: A0A8C0N3I7
Position
9:complement(54777453..54806066)
AA seq 588 aa
MSQARRHLRVALFLAAVSPRGATTGVKARRGLSAWPAPQEPGMEYQDAVRTLNTLQTNAG
YLEQVKRQRGDPQTQLEAMKLYLARSGLQVEDLDQLNIIHVTGTKGKGSTCAFTERILRS
YGLKTGFFSSPHLVQVRERIRINGQPISPELFTKHFWHLYHRLEETKDSNSCVSMPAYFR
FLTLMAFHIFLQEKVDLAVVEVGIGGAYDCTNIIRKPVVCGISSLGLDHTSLLGDTVEEI
AWQKGGIFKRGVPAFTVLQPDGPLAVLQDRAQKISCPLYLCPPLEALEEGGPPLALGLEG
EHQRSNAALALQLARCWLQQKNHQGLGELKVSRPSVLWQMPLAPVFQPTSHMRHGLRDTE
WLGRTQVLRRGPLTWYLDGAHTASSVQACVRWFRQALLRGRVPRRGPEVRVLLFNSTGDR
DPVALLKLLQPCQFDYAVFCPNLTEVSSAGNADQQNFMVTLDQVLLRCLAHQQHWSHLNE
EHASPNLWSPTSLEPGEPTSLLLASHQPHTHSTSSLVFSCISHALQWISQGRDPVFQPPS
PPQGLLAHPVAGSGASLLRDAVAIHVLVTGSLHLVGGVLKLLEPALSQ
NT seq 1767 nt   +upstreamnt  +downstreamnt
atgtcgcaggcacgccgccacctgcgcgtggctctcttcctggcagcagtttccccgcgc
ggtgcaacgaccggggtcaaggcgcggcgagggttgagcgcgtggcccgcgccgcaggag
cccggcatggagtatcaggatgcagtgcgcacactgaataccctgcagaccaatgctggc
tacctggagcaggtaaagcgccagcggggtgatcctcaaacgcagctggaagcaatgaag
ctgtacttggcacggagtggtctgcaggtggaagacttggaccagctgaacatcattcac
gtcactgggaccaaggggaagggctccacttgtgccttcacggaacgtattctccgaagc
tacggcctgaagacaggattctttagctctccccacctggtgcaggtgcgggagcggatc
cgcatcaatgggcagcccataagccctgagctcttcaccaagcatttctggcacctctac
caccggctggaggagaccaaggacagcaatagctgtgtctccatgccggcctacttccgc
ttcctcacactcatggccttccacatcttcctccaggagaaggtagacctggcagtggtg
gaagtgggcattggtggtgcttatgactgcaccaacatcatcaggaagcctgtggtgtgt
ggtatctcctctcttggccttgaccataccagccttctgggggacacagtggaggagatc
gcatggcagaaagggggcatcttcaagcgtggcgtccctgccttcacggtgctccagcct
gacggtcccctggcagtgctgcaggaccgtgcccagaagatctcatgtcctctctacctg
tgcccaccgctggaagccctggaggaaggggggccgccactggccctgggcctggaggga
gagcaccagcggtccaatgccgccttagccttgcagctggctcgctgctggctgcagcaa
aagaaccaccaaggccttggggagctgaaggtgtctcggcccagtgtcctgtggcagatg
cccctggcacccgtgttccagcccacgtcccacatgcggcatgggcttcgggacaccgag
tggttgggccggacgcaggtgctgcggcgcgggcccctcacctggtacttggatggtgcg
cacaccgccagcagcgtgcaggcctgcgtgcgctggttccgccaggcgctgctccgcggc
cgggtgccgaggcgcggccctgaggtgcgcgtcttgcttttcaactccacgggggaccgg
gatcccgtggccctgctcaagctgctgcagccctgtcagtttgactatgctgttttctgc
ccgaacctgacagaggtgtcgtctgctggcaatgcagaccagcagaacttcatggtgacc
ctggatcaggtgttgctccgctgccttgcacaccaacagcactggagccacctgaatgag
gagcacgccagccccaacctctggagccccaccagcctggagcctggtgagcccacctcc
ttgctgctggcttcccaccaaccccacacccatagcaccagctccctcgtcttcagctgc
atctcccacgccctgcagtggatcagccaaggccgggaccctgtctttcagccacccagt
cccccacagggcctccttgcccaccctgtggcaggcagtggggccagcctgctccgcgac
gctgtagccatccatgtactggtcacaggcagcctgcatctagtgggcggtgtcctcaag
ctgctggagcctgccctgtcccagtag

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (10)   
   UniProt (1)   
   RefSeq(pep) (9)   
DNA sequence (9)   
   RefSeq(nuc) (9)   
Protein domain (3)   
   Pfam (3)   
All databases (63)   

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