KEGG   Canis lupus familiaris (dog): 403943
Entry
403943            CDS       T01007                                 
Symbol
GNAS
Name
(RefSeq) guanine nucleotide-binding protein G(s) subunit alpha
  KO
K04632  guanine nucleotide-binding protein G(s) subunit alpha
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01522  Endocrine resistance
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04024  cAMP signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04270  Vascular smooth muscle contraction
cfa04540  Gap junction
cfa04611  Platelet activation
cfa04713  Circadian entrainment
cfa04714  Thermogenesis
cfa04724  Glutamatergic synapse
cfa04726  Serotonergic synapse
cfa04728  Dopaminergic synapse
cfa04730  Long-term depression
cfa04750  Inflammatory mediator regulation of TRP channels
cfa04911  Insulin secretion
cfa04912  GnRH signaling pathway
cfa04913  Ovarian steroidogenesis
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04918  Thyroid hormone synthesis
cfa04921  Oxytocin signaling pathway
cfa04922  Glucagon signaling pathway
cfa04923  Regulation of lipolysis in adipocytes
cfa04924  Renin secretion
cfa04925  Aldosterone synthesis and secretion
cfa04926  Relaxin signaling pathway
cfa04927  Cortisol synthesis and secretion
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa04961  Endocrine and other factor-regulated calcium reabsorption
cfa04962  Vasopressin-regulated water reabsorption
cfa04970  Salivary secretion
cfa04971  Gastric acid secretion
cfa04972  Pancreatic secretion
cfa04976  Bile secretion
cfa05012  Parkinson disease
cfa05030  Cocaine addiction
cfa05031  Amphetamine addiction
cfa05032  Morphine addiction
cfa05034  Alcoholism
cfa05142  Chagas disease
cfa05146  Amoebiasis
cfa05163  Human cytomegalovirus infection
cfa05165  Human papillomavirus infection
cfa05200  Pathways in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    403943 (GNAS)
   04020 Calcium signaling pathway
    403943 (GNAS)
   04072 Phospholipase D signaling pathway
    403943 (GNAS)
   04024 cAMP signaling pathway
    403943 (GNAS)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    403943 (GNAS)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    403943 (GNAS)
  09152 Endocrine system
   04911 Insulin secretion
    403943 (GNAS)
   04922 Glucagon signaling pathway
    403943 (GNAS)
   04923 Regulation of lipolysis in adipocytes
    403943 (GNAS)
   04912 GnRH signaling pathway
    403943 (GNAS)
   04913 Ovarian steroidogenesis
    403943 (GNAS)
   04915 Estrogen signaling pathway
    403943 (GNAS)
   04921 Oxytocin signaling pathway
    403943 (GNAS)
   04926 Relaxin signaling pathway
    403943 (GNAS)
   04935 Growth hormone synthesis, secretion and action
    403943 (GNAS)
   04918 Thyroid hormone synthesis
    403943 (GNAS)
   04928 Parathyroid hormone synthesis, secretion and action
    403943 (GNAS)
   04916 Melanogenesis
    403943 (GNAS)
   04924 Renin secretion
    403943 (GNAS)
   04925 Aldosterone synthesis and secretion
    403943 (GNAS)
   04927 Cortisol synthesis and secretion
    403943 (GNAS)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    403943 (GNAS)
   04270 Vascular smooth muscle contraction
    403943 (GNAS)
  09154 Digestive system
   04970 Salivary secretion
    403943 (GNAS)
   04971 Gastric acid secretion
    403943 (GNAS)
   04972 Pancreatic secretion
    403943 (GNAS)
   04976 Bile secretion
    403943 (GNAS)
  09155 Excretory system
   04962 Vasopressin-regulated water reabsorption
    403943 (GNAS)
   04961 Endocrine and other factor-regulated calcium reabsorption
    403943 (GNAS)
  09156 Nervous system
   04724 Glutamatergic synapse
    403943 (GNAS)
   04728 Dopaminergic synapse
    403943 (GNAS)
   04726 Serotonergic synapse
    403943 (GNAS)
   04730 Long-term depression
    403943 (GNAS)
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    403943 (GNAS)
  09159 Environmental adaptation
   04713 Circadian entrainment
    403943 (GNAS)
   04714 Thermogenesis
    403943 (GNAS)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    403943 (GNAS)
   05207 Chemical carcinogenesis - receptor activation
    403943 (GNAS)
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    403943 (GNAS)
   05165 Human papillomavirus infection
    403943 (GNAS)
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    403943 (GNAS)
   05142 Chagas disease
    403943 (GNAS)
  09164 Neurodegenerative disease
   05012 Parkinson disease
    403943 (GNAS)
  09165 Substance dependence
   05030 Cocaine addiction
    403943 (GNAS)
   05031 Amphetamine addiction
    403943 (GNAS)
   05032 Morphine addiction
    403943 (GNAS)
   05034 Alcoholism
    403943 (GNAS)
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    403943 (GNAS)
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    403943 (GNAS)
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    403943 (GNAS)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:cfa04147]
    403943 (GNAS)
   04031 GTP-binding proteins [BR:cfa04031]
    403943 (GNAS)
Exosome [BR:cfa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   403943 (GNAS)
  Exosomal proteins of other body fluids (saliva and urine)
   403943 (GNAS)
  Exosomal proteins of colorectal cancer cells
   403943 (GNAS)
  Exosomal proteins of bladder cancer cells
   403943 (GNAS)
GTP-binding proteins [BR:cfa04031]
 Heterotrimeric G-proteins
  Alpha Subunits
   Alpha type 2 (Gs)
    403943 (GNAS)
SSDB
Motif
Pfam: G-alpha Arf Gtr1_RagA Roc GTP_EFTU AAA_29 TniB FtsK_SpoIIIE
Other DBs
NCBI-GeneID: 403943
NCBI-ProteinID: NP_001003263
Ensembl: ENSCAFG00000023756
VGNC: 54650
UniProt: P63091
Position
24:42885440..42905085
AA seq 394 aa
MGCLGNSKTEDQRNEEKAQREANKKIEKQLQKDKQVYRATHRLLLLGAGESGKSTIVKQM
RILHVNGFNGEGGEEDPQAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELA
NPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLD
KIDVIKQADYVPSDQDLLRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFND
VTAIIFVVASSSYNMVIREDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEK
VLAGKSKIEDYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCY
PHFTCAVDTENIRRVFNDCRDIIQRMHLRQYELL
NT seq 1185 nt   +upstreamnt  +downstreamnt
atgggctgcctcggaaacagtaagaccgaggaccagcgcaacgaggagaaggcgcagcgc
gaggccaacaaaaagatcgagaagcagctgcagaaggacaagcaggtctaccgggccacg
caccgcctgctgctgctgggtgccggagaatctggtaaaagcaccattgtgaagcagatg
aggatcctgcatgttaatgggtttaatggagagggcggcgaagaggacccgcaagctgca
aggagcaacagcgatggtgagaaggcaaccaaagttcaggacatcaaaaacaacctgaaa
gaggcgatcgaaaccatcgtggccgccatgagcaacctggtgccccccgtggagctggcc
aaccctgagaaccagttcagagtggactacattctgagcgtgatgaacgtgcctgacttt
gacttccctcctgagttctatgagcatgccaaggctctgtgggaggatgaaggagtgcgt
gcctgctatgagcgctccaacgagtaccagctgattgactgcgcccagtacttcctggac
aagattgatgtcatcaagcaggctgactacgtgcccagtgatcaggatctgcttcgctgc
cgtgtcctgacttctggaatctttgagaccaagttccaggtggacaaagtcaacttccac
atgtttgacgtgggtggccagcgcgatgaacgccgcaaatggatccaatgcttcaatgat
gtgactgccatcatcttcgtggtggccagcagcagctacaacatggtcattcgggaggac
aaccagaccaaccgcctgcaggaggctctgaacctcttcaagagcatctggaacaacaga
tggctgcgcaccatctctgtgattctgttcctcaacaagcaagacctgctcgctgagaaa
gtccttgctggaaaatcgaagattgaggactactttccagaatttgctcgctacactact
cctgaggatgctactcccgagcccggagaggacccacgcgtgacccgggccaagtacttc
atccgcgacgaatttctgagaatcagcactgctagtggagatgggcgccactactgctac
ccccacttcacttgcgctgtggacaccgagaacattcgccgtgtgttcaacgactgccgt
gacatcattcagcgcatgcaccttcgtcagtatgagctgctctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (50)   
   KEGG PATHWAY (50)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (11)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (9)   
DNA sequence (11)   
   RefSeq(nuc) (9)   
   GenBank (1)   
   EMBL (1)   
Protein domain (8)   
   Pfam (8)   
All databases (102)   

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