KEGG   Canis lupus familiaris (dog): 415128
Entry
415128            CDS       T01007                                 
Symbol
CYP2E1
Name
(RefSeq) cytochrome P450 2E1
  KO
K07415  cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00140  Steroid hormone biosynthesis
cfa00590  Arachidonic acid metabolism
cfa00591  Linoleic acid metabolism
cfa00980  Metabolism of xenobiotics by cytochrome P450
cfa00982  Drug metabolism - cytochrome P450
cfa00983  Drug metabolism - other enzymes
cfa01100  Metabolic pathways
cfa04932  Non-alcoholic fatty liver disease
cfa04936  Alcoholic liver disease
cfa05204  Chemical carcinogenesis - DNA adducts
cfa05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    415128 (CYP2E1)
   00590 Arachidonic acid metabolism
    415128 (CYP2E1)
   00591 Linoleic acid metabolism
    415128 (CYP2E1)
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    415128 (CYP2E1)
   00982 Drug metabolism - cytochrome P450
    415128 (CYP2E1)
   00983 Drug metabolism - other enzymes
    415128 (CYP2E1)
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    415128 (CYP2E1)
   05208 Chemical carcinogenesis - reactive oxygen species
    415128 (CYP2E1)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    415128 (CYP2E1)
   04932 Non-alcoholic fatty liver disease
    415128 (CYP2E1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450 [BR:cfa00199]
    415128 (CYP2E1)
Cytochrome P450 [BR:cfa00199]
 Cytochrome P450, animal type
  CYP2 family
   415128 (CYP2E1)
SSDB
Motif
Pfam: p450 DUF6361
Other DBs
NCBI-GeneID: 415128
NCBI-ProteinID: NP_001003339
Ensembl: ENSCAFG00000013311
VGNC: 50353
UniProt: Q9MZY0
Position
28:41171673..41181706
AA seq 494 aa
MAALGITVALLVWMATLMLISIWKQIYSRWKLPPGPFPLPIIGNILQVDIKNVPKSLAKL
AEQYGPVFTLYLGSQRTVVLHGYKAVKEVLLDHKNDLSGRGEVFAFQSHKDRGITFNNGP
GWKDTRRLSLSTLRDYGMGKRGNEERIQREIPFLLEALRGTRGQPFDPTFLLGFAPFNVI
ADILFHKHFDYSDQTGLRIQKLFNENFHLLSTGWLQLYNIFPSYLHYLPGSHRKVLRNVA
ELKDYSLERVKEHQESLDPTCSRDFTDCLLQELQKERYGTEPWYTLDNIAVTVADLFFAG
TETTSTTLRYGLLILMKYPEVEEKLHEEIDRVIGPSRVPAIKDRLEMPYMDAVVHEIQRF
IDLLPSNLPHVANQDTMFRGYVIPKGTVVIPTLDSVLFDKQEFPDPEKFKPEHFLNENGK
FKYSDYFKAFSAGKRVCVGEGLARMELFLFLSAILQHFNLKSLVDPKDIDLSPCTIGFAK
IPPHYKLCVVPRSG
NT seq 1485 nt   +upstreamnt  +downstreamnt
atggccgccttgggcatcacagtggccctgctggtgtggatggccaccttaatgcttatc
tctatctggaagcagatctacagccgctggaaactgccccctggcccttttccactgccc
atcattgggaatattctgcaggtggatatcaagaatgttcccaaatctctcgccaagctg
gcagagcagtacgggccagtgttcaccttgtacctgggctcccagcgcacagtggtcctg
catggctacaaggcggtgaaggaagttctgcttgaccacaagaatgacctttctggcaga
ggagaagtcttcgcattccagtcgcacaaggacagagggatcacgttcaacaatgggccc
ggctggaaggacacgcggcgactctccctgagcaccctccgggactacggcatggggaag
cgcggcaacgaggagcggatccagagggagatccccttcctgctggaggcgctcaggggc
acccggggccagcccttcgaccccacctttctcctgggcttcgcccccttcaacgtcatc
gctgacatcctcttccacaagcactttgactactcggatcagactgggctgcggatacag
aagctgttcaacgagaacttccacctgctcagcaccggctggctccagctttataacatt
ttcccaagctatctgcactacctgcccggaagccatagaaaagtcttaagaaatgtggct
gaactaaaggattacagcttagaaagggtgaaggagcaccaggagtcgctggaccccacc
tgctcccgggacttcactgactgcttgctccaggagctgcagaaggagagatacggtacg
gagccttggtataccttggacaacattgccgtgaccgtggctgacctgttctttgcgggc
acggagaccaccagcaccaccctgagatacgggctcctgattctcatgaaatacccagag
gtcgaagagaaacttcatgaagaaatcgacagggtgatcggcccaagccgagtccctgcc
atcaaggacaggctggagatgccctacatggatgccgtggtgcacgagattcagcgattc
atcgacctgctgccctccaacctgccccatgtagcaaaccaggacacgatgttcagagga
tatgtcatccccaagggcacagtggtaattcccacactggactccgtcttgtttgacaaa
caagaattccctgatccagagaagttcaagccagagcactttctgaatgaaaacggaaaa
ttcaaatatagtgactacttcaaggcattctccgcaggaaagcgggtgtgtgttggagaa
ggcctggctcgcatggagctcttcctgttcttgtccgccattttgcagcactttaacctg
aagtctctcgtcgaccccaaggatattgacctcagtccctgcacaatcgggtttgccaag
atccccccccattacaaactctgtgtcgttccccgctcgggctga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (11)   
   KEGG PATHWAY (11)   
Chemical substance (44)   
   KEGG COMPOUND (44)   
Chemical reaction (22)   
   KEGG REACTION (22)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (5)   
   RefSeq(nuc) (1)   
   GenBank (2)   
   EMBL (2)   
Protein domain (2)   
   Pfam (2)   
All databases (98)   

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