KEGG   Canis lupus familiaris (dog): 442949
Entry
442949            CDS       T01007                                 
Symbol
SOCS3
Name
(RefSeq) suppressor of cytokine signaling 3
  KO
K04696  suppressor of cytokine signaling 3
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04120  Ubiquitin mediated proteolysis
cfa04380  Osteoclast differentiation
cfa04630  JAK-STAT signaling pathway
cfa04668  TNF signaling pathway
cfa04910  Insulin signaling pathway
cfa04917  Prolactin signaling pathway
cfa04920  Adipocytokine signaling pathway
cfa04930  Type II diabetes mellitus
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04935  Growth hormone synthesis, secretion and action
cfa05160  Hepatitis C
cfa05164  Influenza A
cfa05168  Herpes simplex virus 1 infection
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    442949 (SOCS3)
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    442949 (SOCS3)
   04668 TNF signaling pathway
    442949 (SOCS3)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    442949 (SOCS3)
   04920 Adipocytokine signaling pathway
    442949 (SOCS3)
   04917 Prolactin signaling pathway
    442949 (SOCS3)
   04935 Growth hormone synthesis, secretion and action
    442949 (SOCS3)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    442949 (SOCS3)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    442949 (SOCS3)
   05164 Influenza A
    442949 (SOCS3)
   05168 Herpes simplex virus 1 infection
    442949 (SOCS3)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    442949 (SOCS3)
   04932 Non-alcoholic fatty liver disease
    442949 (SOCS3)
   04931 Insulin resistance
    442949 (SOCS3)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system [BR:cfa04121]
    442949 (SOCS3)
Ubiquitin system [BR:cfa04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul5 complex
    Target recognizing subunit
     442949 (SOCS3)
SSDB
Motif
Pfam: SH2 SOCS_box
Other DBs
NCBI-GeneID: 442949
NCBI-ProteinID: NP_001026801
VGNC: 46650
UniProt: Q68AM8
Position
9:3516096..3516773
AA seq 225 aa
MVTHSKFPAAGMSRPLDTSLRLKTFSSKSEYQLVVNAVCKLQESGFYWSAVTGGEANLLL
SAEPAGTFLIRDSSDQRHFFTLSVKTQSGTKNLRIQCEGGSFSLQSDPRSTQPVPRFDCV
LKLVHHYMPPPGAPSFPAPPTEPSSEVSEQPPSQPLPGNPPRRAYYIYSGGEKIPLVLSR
PLSSNVATLQHLCRKTVNGHLDSYEKVTQLPGAIREFLDQYDAPL
NT seq 678 nt   +upstreamnt  +downstreamnt
atggtcacccacagcaagtttcccgccgccgggatgagccgccccctggacaccagcctg
cgcctcaagaccttcagctccaagagcgagtaccagctggtggtgaacgcagtgtgcaag
ctgcaggagagcggcttctactggagcgccgtgacgggcggcgaggcgaacctgctgctc
agcgccgagcccgcgggcaccttcctcatccgcgacagctcggaccagcgccacttcttc
acgctcagcgtcaagacccagtcggggaccaagaacctgcgcatccagtgcgaggggggc
agcttctcgctgcagagcgacccccggagcacgcagcccgtgccccgcttcgactgcgtg
ctcaagctggtgcatcactacatgccgccccccggcgcgccctccttccccgctccaccg
actgaaccctcctccgaggtgtcggagcagccgccttcccagccgctccccgggaatccc
cccaggagagcctactacatctactccgggggcgagaagatccctctggtgttgagccgg
cccctctcctccaacgtggccacgctccagcatctctgtcggaagacggtcaatggccac
ctggactcctacgagaaagtcacccagctgcctggggccattcgggaattcctggaccag
tacgatgccccgctttaa

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