KEGG   Canis lupus familiaris (dog): 449021
Entry
449021            CDS       T01007                                 
Symbol
AKT2
Name
(RefSeq) RAC-beta serine/threonine-protein kinase
  KO
K04456  RAC serine/threonine-protein kinase [EC:2.7.11.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04140  Autophagy - animal
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04152  AMPK signaling pathway
cfa04210  Apoptosis
cfa04211  Longevity regulating pathway
cfa04213  Longevity regulating pathway - multiple species
cfa04218  Cellular senescence
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04370  VEGF signaling pathway
cfa04371  Apelin signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
cfa04668  TNF signaling pathway
cfa04722  Neurotrophin signaling pathway
cfa04725  Cholinergic synapse
cfa04728  Dopaminergic synapse
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04920  Adipocytokine signaling pathway
cfa04922  Glucagon signaling pathway
cfa04923  Regulation of lipolysis in adipocytes
cfa04926  Relaxin signaling pathway
cfa04929  GnRH secretion
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04935  Growth hormone synthesis, secretion and action
cfa04936  Alcoholic liver disease
cfa04973  Carbohydrate digestion and absorption
cfa05010  Alzheimer disease
cfa05017  Spinocerebellar ataxia
cfa05132  Salmonella infection
cfa05135  Yersinia infection
cfa05142  Chagas disease
cfa05145  Toxoplasmosis
cfa05152  Tuberculosis
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05162  Measles
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05168  Herpes simplex virus 1 infection
cfa05169  Epstein-Barr virus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05218  Melanoma
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05222  Small cell lung cancer
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05415  Diabetic cardiomyopathy
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    449021 (AKT2)
   04012 ErbB signaling pathway
    449021 (AKT2)
   04014 Ras signaling pathway
    449021 (AKT2)
   04015 Rap1 signaling pathway
    449021 (AKT2)
   04370 VEGF signaling pathway
    449021 (AKT2)
   04371 Apelin signaling pathway
    449021 (AKT2)
   04630 JAK-STAT signaling pathway
    449021 (AKT2)
   04668 TNF signaling pathway
    449021 (AKT2)
   04066 HIF-1 signaling pathway
    449021 (AKT2)
   04068 FoxO signaling pathway
    449021 (AKT2)
   04072 Phospholipase D signaling pathway
    449021 (AKT2)
   04071 Sphingolipid signaling pathway
    449021 (AKT2)
   04024 cAMP signaling pathway
    449021 (AKT2)
   04022 cGMP-PKG signaling pathway
    449021 (AKT2)
   04151 PI3K-Akt signaling pathway
    449021 (AKT2)
   04152 AMPK signaling pathway
    449021 (AKT2)
   04150 mTOR signaling pathway
    449021 (AKT2)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    449021 (AKT2)
  09143 Cell growth and death
   04210 Apoptosis
    449021 (AKT2)
   04218 Cellular senescence
    449021 (AKT2)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    449021 (AKT2)
   04550 Signaling pathways regulating pluripotency of stem cells
    449021 (AKT2)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    449021 (AKT2)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    449021 (AKT2)
   04613 Neutrophil extracellular trap formation
    449021 (AKT2)
   04620 Toll-like receptor signaling pathway
    449021 (AKT2)
   04625 C-type lectin receptor signaling pathway
    449021 (AKT2)
   04660 T cell receptor signaling pathway
    449021 (AKT2)
   04662 B cell receptor signaling pathway
    449021 (AKT2)
   04664 Fc epsilon RI signaling pathway
    449021 (AKT2)
   04666 Fc gamma R-mediated phagocytosis
    449021 (AKT2)
   04062 Chemokine signaling pathway
    449021 (AKT2)
  09152 Endocrine system
   04910 Insulin signaling pathway
    449021 (AKT2)
   04922 Glucagon signaling pathway
    449021 (AKT2)
   04923 Regulation of lipolysis in adipocytes
    449021 (AKT2)
   04920 Adipocytokine signaling pathway
    449021 (AKT2)
   04929 GnRH secretion
    449021 (AKT2)
   04915 Estrogen signaling pathway
    449021 (AKT2)
   04914 Progesterone-mediated oocyte maturation
    449021 (AKT2)
   04917 Prolactin signaling pathway
    449021 (AKT2)
   04926 Relaxin signaling pathway
    449021 (AKT2)
   04935 Growth hormone synthesis, secretion and action
    449021 (AKT2)
   04919 Thyroid hormone signaling pathway
    449021 (AKT2)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    449021 (AKT2)
  09154 Digestive system
   04973 Carbohydrate digestion and absorption
    449021 (AKT2)
  09156 Nervous system
   04725 Cholinergic synapse
    449021 (AKT2)
   04728 Dopaminergic synapse
    449021 (AKT2)
   04722 Neurotrophin signaling pathway
    449021 (AKT2)
  09158 Development and regeneration
   04380 Osteoclast differentiation
    449021 (AKT2)
  09149 Aging
   04211 Longevity regulating pathway
    449021 (AKT2)
   04213 Longevity regulating pathway - multiple species
    449021 (AKT2)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    449021 (AKT2)
   05205 Proteoglycans in cancer
    449021 (AKT2)
   05207 Chemical carcinogenesis - receptor activation
    449021 (AKT2)
   05208 Chemical carcinogenesis - reactive oxygen species
    449021 (AKT2)
   05230 Central carbon metabolism in cancer
    449021 (AKT2)
   05231 Choline metabolism in cancer
    449021 (AKT2)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    449021 (AKT2)
  09162 Cancer: specific types
   05210 Colorectal cancer
    449021 (AKT2)
   05212 Pancreatic cancer
    449021 (AKT2)
   05225 Hepatocellular carcinoma
    449021 (AKT2)
   05226 Gastric cancer
    449021 (AKT2)
   05214 Glioma
    449021 (AKT2)
   05221 Acute myeloid leukemia
    449021 (AKT2)
   05220 Chronic myeloid leukemia
    449021 (AKT2)
   05218 Melanoma
    449021 (AKT2)
   05211 Renal cell carcinoma
    449021 (AKT2)
   05215 Prostate cancer
    449021 (AKT2)
   05213 Endometrial cancer
    449021 (AKT2)
   05224 Breast cancer
    449021 (AKT2)
   05222 Small cell lung cancer
    449021 (AKT2)
   05223 Non-small cell lung cancer
    449021 (AKT2)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    449021 (AKT2)
   05170 Human immunodeficiency virus 1 infection
    449021 (AKT2)
   05161 Hepatitis B
    449021 (AKT2)
   05160 Hepatitis C
    449021 (AKT2)
   05164 Influenza A
    449021 (AKT2)
   05162 Measles
    449021 (AKT2)
   05168 Herpes simplex virus 1 infection
    449021 (AKT2)
   05163 Human cytomegalovirus infection
    449021 (AKT2)
   05167 Kaposi sarcoma-associated herpesvirus infection
    449021 (AKT2)
   05169 Epstein-Barr virus infection
    449021 (AKT2)
   05165 Human papillomavirus infection
    449021 (AKT2)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    449021 (AKT2)
   05135 Yersinia infection
    449021 (AKT2)
   05152 Tuberculosis
    449021 (AKT2)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    449021 (AKT2)
   05142 Chagas disease
    449021 (AKT2)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    449021 (AKT2)
   05017 Spinocerebellar ataxia
    449021 (AKT2)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    449021 (AKT2)
   05418 Fluid shear stress and atherosclerosis
    449021 (AKT2)
   05415 Diabetic cardiomyopathy
    449021 (AKT2)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    449021 (AKT2)
   04932 Non-alcoholic fatty liver disease
    449021 (AKT2)
   04931 Insulin resistance
    449021 (AKT2)
   04933 AGE-RAGE signaling pathway in diabetic complications
    449021 (AKT2)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    449021 (AKT2)
   01524 Platinum drug resistance
    449021 (AKT2)
   01522 Endocrine resistance
    449021 (AKT2)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    449021 (AKT2)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     449021 (AKT2)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: AGC group
  AKT/PKB family
   449021 (AKT2)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr Pkinase_C Kinase-like PH ABC1
Other DBs
NCBI-GeneID: 449021
NCBI-ProteinID: NP_001012340
Ensembl: ENSCAFG00000005388
VGNC: 37772
UniProt: Q5I9W5
Position
1:112790741..112808659
AA seq 419 aa
MKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRGPGEDPMDY
KCGSPSDPSAAEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKASGRYYAMKI
LRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLS
RERVFTEERARFYGAEIVSALEYLHSRDAVYRDIKLENLMLDKDGHIKITDFGLCKEGIS
DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELI
LMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAREVMEHRFFLSVSWQDVVQKKL
LPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGSLELDQRTHFPQFSYSASIRE
NT seq 1260 nt   +upstreamnt  +downstreamnt
atgaagactgagaggccacggcccaacacctttgtcatacgctgcctgcagtggaccact
gtcatcgagaggaccttccacgtagactctccagatgagagggaggagtggatgcgggct
attcagatggtcgccaacagcctcaagcagcggggcccgggtgaggaccccatggactat
aagtgtggctctcccagtgacccttctgcggctgaggagatggaagtggcagttagcaag
gctcgggccaaggtgaccatgaatgacttcgactatctcaagcttctgggcaagggcacc
tttggcaaagtgattctggtgcgggaaaaggccagtggccgctactacgccatgaagatc
ctgcggaaggaagttatcattgccaaggatgaagtcgcccacacggtcaccgagagccgc
gtcctccagaacaccaggcacccattcctcaccgccctgaagtacgccttccagacccat
gaccgcttgtgcttcgtgatggagtatgccaatggtggtgagctgtttttccacctgtcc
cgggagcgtgtcttcacggaggagcgggctcgcttttatggcgcagagatcgtctctgcc
ctcgagtatttgcattcgagggacgcggtataccgtgacatcaagctggaaaacctcatg
ctggacaaagatggccatatcaagatcactgacttcggcctgtgcaaagagggcatcagt
gatggggccaccatgaaaaccttctgtgggacgcctgagtacctggcacccgaggtgctg
gaagacaacgactacggccgcgcggtggactggtgggggctgggcgtggtcatgtacgag
atgatgtgcggccgcctgcccttctacaaccaggaccacgagcgcctcttcgagctcatc
ctcatggaggagatccgcttcccgcgcacactcagccccgaggccaagtccctgcttgcc
gggctgcttaagaaggaccccaagcagaggctcggcggggggcccagcgacgccagggag
gtcatggagcacaggttcttcctcagcgtcagctggcaggacgtggtacagaagaagctt
ctgccacccttcaagcctcaggtcacctctgaggttgacaccaggtactttgacgacgag
ttcactgcccagtccatcacaatcacgcccccggaccgctatgacagcctgggctccctc
gaactggaccagcggacccacttcccccagttctcctactcagccagcatccgcgagtga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (100)   
   KEGG PATHWAY (100)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (8)   
   KEGG ORTHOLOGY (1)   
   RefGene (2)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (8)   
   UniProt (1)   
   RefSeq(pep) (7)   
DNA sequence (13)   
   RefSeq(nuc) (7)   
   GenBank (3)   
   EMBL (3)   
Protein domain (6)   
   Pfam (6)   
All databases (140)   

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