KEGG   Canis lupus familiaris (dog): 475738
Entry
475738            CDS       T01007                                 
Symbol
SLC8A1
Name
(RefSeq) sodium/calcium exchanger 1 precursor
  KO
K05849  solute carrier family 8 (sodium/calcium exchanger)
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04020  Calcium signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04260  Cardiac muscle contraction
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04371  Apelin signaling pathway
cfa04740  Olfactory transduction
cfa04961  Endocrine and other factor-regulated calcium reabsorption
cfa04974  Protein digestion and absorption
cfa04978  Mineral absorption
cfa05410  Hypertrophic cardiomyopathy
cfa05412  Arrhythmogenic right ventricular cardiomyopathy
cfa05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    475738 (SLC8A1)
   04020 Calcium signaling pathway
    475738 (SLC8A1)
   04022 cGMP-PKG signaling pathway
    475738 (SLC8A1)
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    475738 (SLC8A1)
   04261 Adrenergic signaling in cardiomyocytes
    475738 (SLC8A1)
  09154 Digestive system
   04974 Protein digestion and absorption
    475738 (SLC8A1)
   04978 Mineral absorption
    475738 (SLC8A1)
  09155 Excretory system
   04961 Endocrine and other factor-regulated calcium reabsorption
    475738 (SLC8A1)
  09157 Sensory system
   04740 Olfactory transduction
    475738 (SLC8A1)
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    475738 (SLC8A1)
   05412 Arrhythmogenic right ventricular cardiomyopathy
    475738 (SLC8A1)
   05414 Dilated cardiomyopathy
    475738 (SLC8A1)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:cfa02000]
    475738 (SLC8A1)
   00536 Glycosaminoglycan binding proteins [BR:cfa00536]
    475738 (SLC8A1)
Transporters [BR:cfa02000]
 Solute carrier family (SLC)
  SLC8: Na+/Ca2+ exchanger
   475738 (SLC8A1)
Glycosaminoglycan binding proteins [BR:cfa00536]
 Heparan sulfate / Heparin
  Others
   475738 (SLC8A1)
SSDB
Motif
Pfam: Calx-beta Na_Ca_ex_C Na_Ca_ex DnaG_DnaB_bind
Other DBs
NCBI-GeneID: 475738
NCBI-ProteinID: NP_001291891
Ensembl: ENSCAFG00000023592
VGNC: 46480
UniProt: P23685
Structure
Position
17:complement(31772774..32072461)
AA seq 970 aa
MLQLRLLPTFSMGCHLLAVVALLFSHVDLISAETEMEGEGNETGECTGSYYCKKGVILPI
WEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNGETT
KTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMFIII
ALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFFFFP
ICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHVDNF
LDGALVLEVDERDQDDEEARREMARILKELKQKHPEKEIEQLIELANYQVLSQQQKSRAF
YRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVAENDPVSKIFFEQGTYQCLENCG
TVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGETQKEIRVGIIDDD
IFEEDENFLVHLSNVKVSSEASEDGILEANHVSALACLGSPSTATVTIFDDDHAGIFTFE
EPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIV
KTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLYGQPVFRK
VHAREHPIPSTVITIAEEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESYEFK
STVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHFLTV
FWKVLFAFVPPTEYWNGWACFIVSILMIGILTAFIGDLASHFGCTIGLKDSVTAVVFVAL
GTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQFKVS
PGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIFFSS
LEAYCHIKGF
NT seq 2913 nt   +upstreamnt  +downstreamnt
atgctgcagttaagactattacctaccttttcaatgggatgtcatctgttagccgttgtg
gctctcttattttcccacgtggaccttataagtgcagagacagaaatggaaggagaaggc
aatgaaaccggcgagtgtactggctcatattattgtaagaagggggtgattttacccatt
tgggagccccaagacccttcctttggagacaaaattgccagagctactgtgtattttgtg
gccatggtctacatgtttctcggagtctctatcattgctgaccggttcatgtcctctata
gaagtcatcacatctcaagaaaaagaaataaccataaagaaacccaatggagagaccacc
aagaccactgtgaggatctggaatgagactgtttccaatctaaccttgatggccctggga
tcttctgctccagagattctcctttcagtaattgaagtatgtggccataacttcactgca
ggagacctaggtcccagcaccattgtgggaagtgctgcattcaacatgttcatcatcatc
gcgctttgtgtttatgtggtcccagatggagagacaaggaagattaagcatttgcgtgtg
ttcttcgtgacagcagcctggagcatctttgcctatacgtggctttacattattttgtct
gtcatctctcctggggtcgtggaagtctgggaaggtttgcttactttcttcttctttcct
atctgtgttgtgttcgcttgggtggcagataggaggctgctgttttacaagtatgtctac
aagaggtatcgggccggcaagcagaggggaatgatcatcgagcacgaaggagacaggcca
tcttccaagactgaaattgaaatggatgggaaagtggtcaattcccacgttgacaatttc
ttagatggtgctctggttctggaggttgatgagagggaccaagatgatgaagaggcgagg
cgagaaatggctaggattctgaaggagctcaagcagaagcatccggagaaagaaatagag
caattgattgaattagctaactaccaagtcctaagtcagcagcagaaaagccgagcattt
taccgcatccaagctactcgcctgatgactggagctggcaacattttaaagaggcacgca
gctgaccaggcaaggaaggctgtcagcatgcatgaggtcaacactgaagtggctgaaaat
gaccccgtgagtaagatcttctttgaacaagggacctatcagtgtctggagaactgtggg
actgtagccctgaccattatccgcagaggtggcgatttgactaacactgtgtttgttgac
ttcagaacagaggatggcacggccaacgctggctctgattatgaatttactgaaggaact
gtggtctttaagccaggtgagacccagaaggaaatcagagttggcatcatcgatgatgac
atctttgaggaggatgagaatttccttgtgcacttgagcaatgttaaagtatcttctgag
gcctcagaagacggcatcctggaagccaatcatgtttctgcgctcgcttgcctgggatct
ccctccaccgccaccgtgacgatttttgacgatgaccacgctggcatctttacttttgag
gagcccgtgactcacgtgagtgagagcattggcattatggaggtgaaggtattgcgaaca
tctggagctcgaggaaatgttatcgttccctataaaaccatcgaagggactgccagaggt
ggaggggaggactttgaggacacttgtggagagctcgaattccagaacgatgaaattgtc
aaaacaatatcagtcaaggtaattgatgatgaggagtatgagaaaaacaagaccttcttc
cttgagattggagagccccgcctggtggagatgagtgagaagaaagccctgttattgaat
gagcttggtggcttcacaataacaggaaaatacctgtatggccaacctgtcttccggaaa
gttcatgctagagaacatccgattccctctactgtaatcaccattgcagaggaatatgat
gacaagcaaccgctgaccagcaaagaggaggaggagaggcgcattgcagaaatggggcgg
cccattctgggagaacacaccaagctggaagtgatcattgaagaatcctatgaattcaag
agtaccgtggacaaacttattaagaagacaaacttagcccttgtggttgggacaaacagc
tggagagagcagtttattgaagccatcaccgtcagtgctggggaagatgatgacgacgat
gaatgtggagaggagaagctgccctcctgtttcgattatgtgatgcattttctgactgtg
ttctggaaagtcctcttcgccttcgtccccccgacagaatactggaatggctgggcctgt
ttcattgtctccatcctcatgattggcatactgacagctttcattggagacctggcttcc
cactttggatgcaccatcggcttgaaagattctgtgactgcggtagtgttcgtcgcactt
ggaacttcggtaccagacacatttgcaagcaaagtggcagccacccaggatcagtatgca
gacgcgtccataggtaacgtcactggcagcaacgcggtgaacgtctttctgggaatcggc
gtggcctggtccatcgctgccatctaccatgcagccaatggggaacagttcaaagtgtcc
cctggcacgctagctttctctgtcactctcttcaccatttttgctttcatcaatgtgggg
gtgctgctgtatcggcggaggccagagatcggaggtgagctgggtgggccccggactgcc
aagctcctcacatcctgcctcttcgtgctcctatggctcttgtacattttcttctcctcc
ctggaggcctactgccacataaaaggcttctaa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (12)   
   KEGG PATHWAY (12)   
Genome (1)   
   KEGG GENOME (1)   
Gene (12)   
   KEGG ORTHOLOGY (1)   
   RefGene (6)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (24)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (22)   
DNA sequence (22)   
   RefSeq(nuc) (22)   
3D Structure (8)   
   PDB (8)   
Protein domain (4)   
   Pfam (4)   
All databases (86)   

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