KEGG   Canis lupus familiaris (dog): 476215
Entry
476215            CDS       T01007                                 
Symbol
MAP3K5
Name
(RefSeq) mitogen-activated protein kinase kinase kinase 5
  KO
K04426  mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01524  Platinum drug resistance
cfa04010  MAPK signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04141  Protein processing in endoplasmic reticulum
cfa04210  Apoptosis
cfa04530  Tight junction
cfa04668  TNF signaling pathway
cfa04714  Thermogenesis
cfa04722  Neurotrophin signaling pathway
cfa04932  Non-alcoholic fatty liver disease
cfa04936  Alcoholic liver disease
cfa05010  Alzheimer disease
cfa05012  Parkinson disease
cfa05014  Amyotrophic lateral sclerosis
cfa05016  Huntington disease
cfa05017  Spinocerebellar ataxia
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05417  Lipid and atherosclerosis
cfa05418  Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    476215 (MAP3K5)
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    476215 (MAP3K5)
   04668 TNF signaling pathway
    476215 (MAP3K5)
   04071 Sphingolipid signaling pathway
    476215 (MAP3K5)
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    476215 (MAP3K5)
  09144 Cellular community - eukaryotes
   04530 Tight junction
    476215 (MAP3K5)
 09150 Organismal Systems
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    476215 (MAP3K5)
  09159 Environmental adaptation
   04714 Thermogenesis
    476215 (MAP3K5)
 09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    476215 (MAP3K5)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    476215 (MAP3K5)
   05012 Parkinson disease
    476215 (MAP3K5)
   05014 Amyotrophic lateral sclerosis
    476215 (MAP3K5)
   05016 Huntington disease
    476215 (MAP3K5)
   05017 Spinocerebellar ataxia
    476215 (MAP3K5)
   05022 Pathways of neurodegeneration - multiple diseases
    476215 (MAP3K5)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    476215 (MAP3K5)
   05418 Fluid shear stress and atherosclerosis
    476215 (MAP3K5)
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    476215 (MAP3K5)
   04932 Non-alcoholic fatty liver disease
    476215 (MAP3K5)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    476215 (MAP3K5)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    476215 (MAP3K5)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.25  mitogen-activated protein kinase kinase kinase
     476215 (MAP3K5)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: STE group
  STE11 family
   476215 (MAP3K5)
SSDB
Motif
Pfam: MAP3K_TRAF_bd Pkinase HisK-N-like PK_Tyr_Ser-Thr ASK_PH TPR-S DRHyd-ASK Kinase-like Pkinase_fungal
Other DBs
NCBI-GeneID: 476215
NCBI-ProteinID: XP_533420
Ensembl: ENSCAFG00000000251
VGNC: 42975
UniProt: A0A8C0RVK6 A0A8I3RT53
Position
1:complement(29990542..30188619)
AA seq 1366 aa
MSAEAGEGITFSVPPFAEGGSCRRGGAAAPAEGPESQLPPPPPGSFWNVESAAAPGAGCP
AATSASSATRCRGSSGGGGGRRTTVAYVINEASQGQLVVAESEALQSLREACETVGATLE
TLHFGKLDFGETTVLDRFYNADIAVVEMSDAFRQPSLFYHLGVRESFSMANNIILYCDNN
SDSLQSLKEIICQKNTMCTGNYTFVPYMITPHNKVYCCDSSFMKGLTELMQPNFELLLGP
ICLPLVDRFIQLLKVAQASSSQYFRESILNDIRKARNLYTGKELAAELARIRQRVDNIEV
LTADIVINLLLSYRDIQDYDSIVKLVETLEKLPTFDLASHHHVKFHYAFALNRRNLPGDR
AKALDVMIPLVQSEGQVASDMYCLVGRIYKDMFLDSNFLDTESRDHGASWFKKAFESEPS
LQSGINYAVLLLAAGHQFESSFELRKVGVKLSSLLGKKGNLEKLQSYWEVGFFLGASVLA
NDHMRVIQASEKLFKLKTPAWYLKSIVETILIYKHFVKLTTDQPVAKQELVDFWMDFLVE
ATKTDVTVVRFPVLILEPTKIYQPSYLSINNEVEEKTISIWHVLPDDKKGIHEWNFSASS
VRGVSISKFEERCCFLYVLHNSDDFQIYFCTELHCKKFFEMVNTITEEKGRSTEEGDCET
DSLEYDYEYDENGDRVVLGKGTYGIVYAGRDLSNQVRIAIKEIPERDSRYSQPLHEEIAL
HKHLKHKNIVQYLGSFSENGFIKIFMEQVPGGSLSALLRSKWGPLKDNEQTIGFYTKQIL
EGLKYLHDNQIVHRDIKGDNVLINTYSGVLKISDFGTSKRLAGINPCTETFTGTLQYMAP
EIIDKGPRGYGKAADIWSLGCTIIEMATGKPPFYELGEPQAAMFKVGMFKVHPEIPESMS
AEAKAFILKCFEPDPDKRACANDLLIDEFLKVSSKKKKTQPKLSALSAGSNEYLRSISLP
VPVLVEDTSSSSEYGSVSPDTELRVDPFSFKMRAKSCGERDVKGIRTLFLGIPDENFEDH
SAPPSPEEKDSGFFMLRKDSERRATLHRILTEDQDKVVRNLMESLAQGPEEPKLKWEHIT
TLIASLREFVRSTDRKIIATTLSKLKLELDFDSHGISQVQVVLFGFQDAVNKVLRNHNIK
PHWMFALDSIIRKAVQTAITILVPELRPHFSLASESDTADQEDLDAEDDHEEQPSSQTVR
RPHAVIEDAVATSGVSTLSSTVSHDSQNAHRSLNVQLGRMKIETNRLLEELVQKEKELQA
LLHQAIEEKDQEIKHLKLKSQPIEIPGLPVCPRDSPGTNTEESELTEWLRDKGADEDTIS
RFLAEDYSLEDVLYYVTRDDLKCLRLRGGMLCTLWKAITDFRDTQA
NT seq 4101 nt   +upstreamnt  +downstreamnt
atgagcgccgaggcgggcgagggcatcactttctccgtgccacccttcgccgagggcggc
agctgccggaggggaggagcggcggcgccggccgagggcccggagagccaactaccaccg
ccgccgccgggcagcttctggaacgtggagagtgccgccgccccgggcgccggctgtccg
gctgccacctctgcgagcagcgccacccggtgccggggcagctctggtggcggaggcggc
cgacggaccacggtggcttatgtgatcaacgaagcgagccaggggcagctggtggtggcc
gagagcgaggccctgcagagcctgcgggaggcgtgcgagacggtgggcgccaccctggag
accctgcattttggcaaactggacttcggggaaaccacggtgctggaccgcttttacaac
gcagatattgctgtggtggagatgagtgatgccttccggcagccgtccttgttttaccac
ctgggagtgagagaaagtttcagcatggccaacaacatcatcctctactgtgataataat
tcagactctctgcagtcactgaaggaaatcatttgccagaagaatactatgtgcactggg
aactacacattcgtcccttacatgataactccacataacaaggtctactgctgtgatagc
agcttcatgaaagggttgacagagctcatgcaaccgaacttcgagctgcttctgggaccc
atatgcttacctcttgtggaccgtttcattcagcttctgaaggtggcacaagcaagttct
agccagtacttccgggaatctatactcaatgatatcaggaaagctcgtaatttatacact
ggtaaagaattggcagctgaattggcaagaattcggcagcgagtagacaatattgaagtc
ttgacagcagatattgtcataaacctgttactttcctacagagatatccaggactatgat
tctattgtgaagctggtagagacgttagaaaaactgccaacttttgatttggcttcccat
caccatgtgaagtttcattatgcatttgcactgaataggagaaacctccctggagataga
gcaaaagctcttgatgttatgatccccttggtgcaaagtgaagggcaggttgcttcagat
atgtattgcctagttggtcgaatctacaaagatatgtttttggactctaatttcctggac
actgagagtagagaccatggagcttcttggttcaaaaaggcatttgaatctgagccatca
ctacagtcaggaattaattatgcagtccttctcctggcagctgggcaccagtttgaatct
tcctttgagctccggaaagttggagtgaagctgagtagcctccttggtaaaaagggaaac
ttagaaaaactccagagctactgggaagttggattttttctgggtgccagtgtcttggcc
aatgatcacatgagagtcatccaagcatctgaaaagctttttaagctgaagacacccgca
tggtacctcaaatctattgtagagacaattttgatatataagcattttgtgaaactgact
acagaccagcctgtggccaaacaggagctcgtggacttctggatggatttcctggttgaa
gccacaaagacagatgttaccgtagttaggtttccagtattaatattagaaccaaccaaa
atctatcagccttcatatttgtctatcaacaatgaagttgaggaaaagaccatatctatt
tggcacgtgcttcctgatgacaagaaaggtatacatgagtggaattttagtgcttcttct
gtcaggggagtgagtatttctaaatttgaagaacgatgctgttttctttatgtgcttcat
aattctgatgatttccaaatctacttctgtacagaacttcattgtaaaaagttttttgaa
atggtgaacaccatcactgaagagaaggggagaagcacagaggaaggtgattgtgaaact
gactccctggagtatgactatgaatatgatgagaatggtgacagagtcgttctagggaaa
ggcacttatgggatcgtctacgcaggccgagacctgagcaaccaagtcagaatcgctata
aaggaaatcccagagagagatagcagatactctcagcctctacatgaagaaatagcattg
cataagcatctgaagcacaaaaatattgtccagtatctgggctctttcagtgagaatggt
ttcatcaaaatcttcatggagcaggtcccaggaggaagtctttctgctctccttcgttcc
aaatggggcccattgaaggacaatgagcaaacaattggcttttatacaaagcaaatactt
gaaggattaaaatacctccatgacaatcaaatagtccaccgagatataaagggcgacaac
gtgttgattaatacctatagtggtgttctcaagatctcggacttcgggacatcaaagagg
ctcgctggcataaacccatgtactgaaacttttactggtactcttcagtacatggcacca
gagatcatagacaaaggaccacgaggctacgggaaagcagcagacatctggtctttgggc
tgcacaatcatcgaaatggccacagggaaaccacctttctatgaactgggagaaccacaa
gcagctatgttcaaggtgggaatgtttaaagtccacccggagattccagagtccatgtca
gcagaggccaaggcattcatactgaagtgttttgaaccagaccctgacaagagagcctgt
gctaacgacttgcttattgatgaattcttaaaagtttcaagcaaaaagaaaaagacacaa
cctaagctttcagccctctcagctggatcaaatgagtatcttagaagcatatccttgccg
gtgcctgtcctggtggaagacacgagcagcagcagcgagtacggctcggtttcccccgac
acggagttaagggtggaccccttctctttcaaaatgagagccaaatcctgtggagagaga
gatgtaaaaggaatacggacactctttttgggcattccggatgaaaattttgaagaccac
agtgctcccccttcccctgaagaaaaagattctggattctttatgctgagaaaggacagt
gagagacgggccacccttcataggatcctgactgaagaccaagacaaagtcgtgagaaac
ttaatggaatctttggcccaggggcctgaagaacctaagctaaaatgggaacatatcaca
accctcatcgcaagcctcagagagtttgtgagatccactgaccgaaaaatcatagccacc
acactgtccaagctgaagctggaacttgactttgacagccatggcattagtcaagtacag
gtggtgctcttcggctttcaggatgctgtcaataaagttcttcggaatcataatatcaag
ccacactggatgtttgccttagacagtatcatccgaaaggcagtgcagacggccattacc
attctggttccagaactgaggccacacttcagccttgcatctgagagtgataccgctgat
caagaagacttggatgcagaagatgaccatgaagagcagccttccagccaaactgtccga
agacctcatgctgtcattgaagatgctgtggctacctcaggggtgagcacgctcagttct
actgtatcccacgactcccagaatgctcaccgctcactcaatgtgcagctcggaaggatg
aaaatagaaactaatagactactggaagaattggttcagaaagagaaagaattacaggca
ctccttcatcaagcaattgaagaaaaagaccaagaaattaaacatctgaaacttaagtcc
caaccaatagagattccgggattgccagtatgcccccgggattctcctggcacaaatact
gaagaatctgaacttactgagtggctgagagacaagggagctgatgaagacactataagt
cggtttttggctgaggattattcactagaggatgttctctactatgttacacgtgatgat
ttaaaatgcctgagactaaggggagggatgctctgcacactgtggaaggccatcaccgac
tttcgagacacacaggcttga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (20)   
   KEGG PATHWAY (20)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (7)   
   UniProt (2)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (9)   
   Pfam (9)   
All databases (67)   

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