KEGG   Canis lupus familiaris (dog): 477488
Entry
477488            CDS       T01007                                 
Symbol
PTPN11
Name
(RefSeq) tyrosine-protein phosphatase non-receptor type 11 isoform X1
  KO
K07293  tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04014  Ras signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04148  Efferocytosis
cfa04360  Axon guidance
cfa04625  C-type lectin receptor signaling pathway
cfa04630  JAK-STAT signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04660  T cell receptor signaling pathway
cfa04670  Leukocyte transendothelial migration
cfa04722  Neurotrophin signaling pathway
cfa04920  Adipocytokine signaling pathway
cfa04931  Insulin resistance
cfa05168  Herpes simplex virus 1 infection
cfa05205  Proteoglycans in cancer
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05211  Renal cell carcinoma
cfa05220  Chronic myeloid leukemia
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    477488 (PTPN11)
   04630 JAK-STAT signaling pathway
    477488 (PTPN11)
   04072 Phospholipase D signaling pathway
    477488 (PTPN11)
 09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    477488 (PTPN11)
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    477488 (PTPN11)
   04650 Natural killer cell mediated cytotoxicity
    477488 (PTPN11)
   04660 T cell receptor signaling pathway
    477488 (PTPN11)
   04670 Leukocyte transendothelial migration
    477488 (PTPN11)
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    477488 (PTPN11)
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    477488 (PTPN11)
  09158 Development and regeneration
   04360 Axon guidance
    477488 (PTPN11)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    477488 (PTPN11)
   05208 Chemical carcinogenesis - reactive oxygen species
    477488 (PTPN11)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    477488 (PTPN11)
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    477488 (PTPN11)
   05211 Renal cell carcinoma
    477488 (PTPN11)
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    477488 (PTPN11)
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    477488 (PTPN11)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins [BR:cfa01009]
    477488 (PTPN11)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     477488 (PTPN11)
Protein phosphatases and associated proteins [BR:cfa01009]
 Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    477488 (PTPN11)
SSDB
Motif
Pfam: Y_phosphatase SH2 DSPc Y_phosphatase3 PTPlike_phytase
Other DBs
NCBI-GeneID: 477488
NCBI-ProteinID: XP_005636307
Ensembl: ENSCAFG00000008894
VGNC: 45168
UniProt: A0A8C0TMQ6
Position
26:10107654..10190288
AA seq 597 aa
MTSRRWFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTG
DYYDLYGGEKFATLAELVQYYMEHHGQLKEKNGDVIELKYPLNCADPTSERWFHGHLSGK
EAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDDKGESNDGKSKVTHVMIRCQELKYD
VGGGERFDSLTDLVEHYKKNPMVETLGTVLQLKQPLNTTRINAAEIESRVRELSKLAETT
DKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEP
VSDYINANIIMPEFETKCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
ERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVW
QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESITDAGPVVVHCSAGIGRTGTFIVIDILI
DIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSK
RKGHEYTNIKYSLTDQTSGDQSPLPPCTPTPSCAEMREDNARVYENVGLMQQQKSFR
NT seq 1794 nt   +upstreamnt  +downstreamnt
atgacatcgcggagatggtttcacccaaacatcactggcgtggaggcagaaaacctgctg
ttgacaagaggagttgatggcagttttttggcgaggcccagtaaaagtaatcctggagac
ttcaccctttccgtcagaagaaatggcgctgtcacccacatcaagattcagaacactggt
gattactatgacttgtatggaggggaaaagtttgccacgttggctgagttggtccagtat
tatatggaacatcacggacaattaaaagagaagaatggagatgttattgagcttaaatat
cctctgaactgtgcagatcctacctctgaaaggtggtttcatggacacctgtctgggaaa
gaagcagagaaattactaactgagaaaggaaaacacggtagcttcctggtacgagagagc
cagagccaccctggagattttgttctctctgtccgcactggtgatgacaaaggggagagc
aatgatggcaagtctaaagtgacccatgtcatgatccgttgtcaggaactgaaatatgat
gttggtggaggagaacggtttgactctttgacagatcttgtggagcattataagaagaat
cccatggtggaaactttgggcacagtactacaacttaagcagcccctcaacacaacacgt
atcaatgcagctgaaatagaaagccgggttcgagaactaagcaaattagctgagaccaca
gataaagtcaaacaaggcttttgggaagaatttgagacactacaacaacaggagtgcaaa
cttctttatagccgaaaagagggtcagaggcaagaaaataagaacaaaaatagatataaa
aacatcctgccttttgatcataccagggttgtcctgcatgatggtgatcctaatgagcct
gtttcagattacatcaatgcaaatattatcatgcctgagtttgaaaccaaatgcaacaat
tcaaagcccaaaaagagttacattgccacacaaggctgtctgcaaaacaccgtgaatgac
ttttggcggatggtatttcaagagaactcccgagtgattgtcatgacaacgaaagaagtg
gagagaggaaagagtaaatgtgtcaaatactggcctgacgagtatgctctgaaagaatat
ggggtcatgcgtgttaggaacgtcaaagaaagtgctgctcatgactatacattaagagag
cttaaactttcaaaggttggacaagctctactccaggggaatacagagagaaccgtgtgg
caataccactttcggacctggccggaccacggagtgcccagtgaccctgggggcgtgctg
gacttcttggaggaggtccatcataagcaggagagcattacggatgcagggcctgtggtg
gttcactgcagtgctgggattggccggacagggacgttcattgtgattgatatccttatt
gacatcatcagagagaaaggtgttgactgcgacattgatgttcccaaaaccattcagatg
gtgcggtctcagaggtcagggatggtccagacagaagcacagtaccgattcatttatatg
gctgtccagcattacattgaaacactacagcgcaggattgaggaagagcagaaaagcaag
aggaaagggcatgaatatacaaatattaagtattctctaacggaccagacaagtggagat
cagagtcccctcccgccttgtaccccaacaccatcttgtgcagaaatgagagaagataat
gctagagtctatgaaaatgtgggtctgatgcagcagcagaaaagtttcagatga

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (18)   
   KEGG PATHWAY (18)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (11)   
   UniProt (1)   
   RefSeq(pep) (10)   
DNA sequence (12)   
   RefSeq(nuc) (10)   
   GenBank (1)   
   EMBL (1)   
Protein domain (5)   
   Pfam (5)   
All databases (64)   

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