KEGG   Canis lupus familiaris (dog): 477575
Entry
477575            CDS       T01007                                 
Symbol
MAPK1
Name
(RefSeq) mitogen-activated protein kinase 1
  KO
K04371  mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01521  EGFR tyrosine kinase inhibitor resistance
cfa01522  Endocrine resistance
cfa01524  Platinum drug resistance
cfa04010  MAPK signaling pathway
cfa04012  ErbB signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04024  cAMP signaling pathway
cfa04062  Chemokine signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04071  Sphingolipid signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04114  Oocyte meiosis
cfa04140  Autophagy - animal
cfa04148  Efferocytosis
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04210  Apoptosis
cfa04218  Cellular senescence
cfa04261  Adrenergic signaling in cardiomyocytes
cfa04270  Vascular smooth muscle contraction
cfa04350  TGF-beta signaling pathway
cfa04360  Axon guidance
cfa04370  VEGF signaling pathway
cfa04371  Apelin signaling pathway
cfa04380  Osteoclast differentiation
cfa04510  Focal adhesion
cfa04520  Adherens junction
cfa04540  Gap junction
cfa04550  Signaling pathways regulating pluripotency of stem cells
cfa04611  Platelet activation
cfa04613  Neutrophil extracellular trap formation
cfa04620  Toll-like receptor signaling pathway
cfa04621  NOD-like receptor signaling pathway
cfa04625  C-type lectin receptor signaling pathway
cfa04650  Natural killer cell mediated cytotoxicity
cfa04657  IL-17 signaling pathway
cfa04658  Th1 and Th2 cell differentiation
cfa04659  Th17 cell differentiation
cfa04660  T cell receptor signaling pathway
cfa04662  B cell receptor signaling pathway
cfa04664  Fc epsilon RI signaling pathway
cfa04666  Fc gamma R-mediated phagocytosis
cfa04668  TNF signaling pathway
cfa04713  Circadian entrainment
cfa04720  Long-term potentiation
cfa04722  Neurotrophin signaling pathway
cfa04723  Retrograde endocannabinoid signaling
cfa04724  Glutamatergic synapse
cfa04725  Cholinergic synapse
cfa04726  Serotonergic synapse
cfa04730  Long-term depression
cfa04810  Regulation of actin cytoskeleton
cfa04910  Insulin signaling pathway
cfa04912  GnRH signaling pathway
cfa04914  Progesterone-mediated oocyte maturation
cfa04915  Estrogen signaling pathway
cfa04916  Melanogenesis
cfa04917  Prolactin signaling pathway
cfa04919  Thyroid hormone signaling pathway
cfa04921  Oxytocin signaling pathway
cfa04926  Relaxin signaling pathway
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa04929  GnRH secretion
cfa04930  Type II diabetes mellitus
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa04934  Cushing syndrome
cfa04935  Growth hormone synthesis, secretion and action
cfa04960  Aldosterone-regulated sodium reabsorption
cfa05010  Alzheimer disease
cfa05020  Prion disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05034  Alcoholism
cfa05132  Salmonella infection
cfa05133  Pertussis
cfa05135  Yersinia infection
cfa05140  Leishmaniasis
cfa05142  Chagas disease
cfa05145  Toxoplasmosis
cfa05152  Tuberculosis
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05163  Human cytomegalovirus infection
cfa05164  Influenza A
cfa05165  Human papillomavirus infection
cfa05166  Human T-cell leukemia virus 1 infection
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05170  Human immunodeficiency virus 1 infection
cfa05171  Coronavirus disease - COVID-19
cfa05200  Pathways in cancer
cfa05203  Viral carcinogenesis
cfa05205  Proteoglycans in cancer
cfa05206  MicroRNAs in cancer
cfa05207  Chemical carcinogenesis - receptor activation
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05210  Colorectal cancer
cfa05211  Renal cell carcinoma
cfa05212  Pancreatic cancer
cfa05213  Endometrial cancer
cfa05214  Glioma
cfa05215  Prostate cancer
cfa05216  Thyroid cancer
cfa05218  Melanoma
cfa05219  Bladder cancer
cfa05220  Chronic myeloid leukemia
cfa05221  Acute myeloid leukemia
cfa05223  Non-small cell lung cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
cfa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    477575 (MAPK1)
   04012 ErbB signaling pathway
    477575 (MAPK1)
   04014 Ras signaling pathway
    477575 (MAPK1)
   04015 Rap1 signaling pathway
    477575 (MAPK1)
   04350 TGF-beta signaling pathway
    477575 (MAPK1)
   04370 VEGF signaling pathway
    477575 (MAPK1)
   04371 Apelin signaling pathway
    477575 (MAPK1)
   04668 TNF signaling pathway
    477575 (MAPK1)
   04066 HIF-1 signaling pathway
    477575 (MAPK1)
   04068 FoxO signaling pathway
    477575 (MAPK1)
   04072 Phospholipase D signaling pathway
    477575 (MAPK1)
   04071 Sphingolipid signaling pathway
    477575 (MAPK1)
   04024 cAMP signaling pathway
    477575 (MAPK1)
   04022 cGMP-PKG signaling pathway
    477575 (MAPK1)
   04151 PI3K-Akt signaling pathway
    477575 (MAPK1)
   04150 mTOR signaling pathway
    477575 (MAPK1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    477575 (MAPK1)
   04148 Efferocytosis
    477575 (MAPK1)
  09143 Cell growth and death
   04114 Oocyte meiosis
    477575 (MAPK1)
   04210 Apoptosis
    477575 (MAPK1)
   04218 Cellular senescence
    477575 (MAPK1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    477575 (MAPK1)
   04520 Adherens junction
    477575 (MAPK1)
   04540 Gap junction
    477575 (MAPK1)
   04550 Signaling pathways regulating pluripotency of stem cells
    477575 (MAPK1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    477575 (MAPK1)
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    477575 (MAPK1)
   04613 Neutrophil extracellular trap formation
    477575 (MAPK1)
   04620 Toll-like receptor signaling pathway
    477575 (MAPK1)
   04621 NOD-like receptor signaling pathway
    477575 (MAPK1)
   04625 C-type lectin receptor signaling pathway
    477575 (MAPK1)
   04650 Natural killer cell mediated cytotoxicity
    477575 (MAPK1)
   04660 T cell receptor signaling pathway
    477575 (MAPK1)
   04658 Th1 and Th2 cell differentiation
    477575 (MAPK1)
   04659 Th17 cell differentiation
    477575 (MAPK1)
   04657 IL-17 signaling pathway
    477575 (MAPK1)
   04662 B cell receptor signaling pathway
    477575 (MAPK1)
   04664 Fc epsilon RI signaling pathway
    477575 (MAPK1)
   04666 Fc gamma R-mediated phagocytosis
    477575 (MAPK1)
   04062 Chemokine signaling pathway
    477575 (MAPK1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    477575 (MAPK1)
   04929 GnRH secretion
    477575 (MAPK1)
   04912 GnRH signaling pathway
    477575 (MAPK1)
   04915 Estrogen signaling pathway
    477575 (MAPK1)
   04914 Progesterone-mediated oocyte maturation
    477575 (MAPK1)
   04917 Prolactin signaling pathway
    477575 (MAPK1)
   04921 Oxytocin signaling pathway
    477575 (MAPK1)
   04926 Relaxin signaling pathway
    477575 (MAPK1)
   04935 Growth hormone synthesis, secretion and action
    477575 (MAPK1)
   04919 Thyroid hormone signaling pathway
    477575 (MAPK1)
   04928 Parathyroid hormone synthesis, secretion and action
    477575 (MAPK1)
   04916 Melanogenesis
    477575 (MAPK1)
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    477575 (MAPK1)
   04270 Vascular smooth muscle contraction
    477575 (MAPK1)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    477575 (MAPK1)
  09156 Nervous system
   04724 Glutamatergic synapse
    477575 (MAPK1)
   04725 Cholinergic synapse
    477575 (MAPK1)
   04726 Serotonergic synapse
    477575 (MAPK1)
   04720 Long-term potentiation
    477575 (MAPK1)
   04730 Long-term depression
    477575 (MAPK1)
   04723 Retrograde endocannabinoid signaling
    477575 (MAPK1)
   04722 Neurotrophin signaling pathway
    477575 (MAPK1)
  09158 Development and regeneration
   04360 Axon guidance
    477575 (MAPK1)
   04380 Osteoclast differentiation
    477575 (MAPK1)
  09159 Environmental adaptation
   04713 Circadian entrainment
    477575 (MAPK1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    477575 (MAPK1)
   05206 MicroRNAs in cancer
    477575 (MAPK1)
   05205 Proteoglycans in cancer
    477575 (MAPK1)
   05207 Chemical carcinogenesis - receptor activation
    477575 (MAPK1)
   05208 Chemical carcinogenesis - reactive oxygen species
    477575 (MAPK1)
   05203 Viral carcinogenesis
    477575 (MAPK1)
   05230 Central carbon metabolism in cancer
    477575 (MAPK1)
   05231 Choline metabolism in cancer
    477575 (MAPK1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    477575 (MAPK1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    477575 (MAPK1)
   05212 Pancreatic cancer
    477575 (MAPK1)
   05225 Hepatocellular carcinoma
    477575 (MAPK1)
   05226 Gastric cancer
    477575 (MAPK1)
   05214 Glioma
    477575 (MAPK1)
   05216 Thyroid cancer
    477575 (MAPK1)
   05221 Acute myeloid leukemia
    477575 (MAPK1)
   05220 Chronic myeloid leukemia
    477575 (MAPK1)
   05218 Melanoma
    477575 (MAPK1)
   05211 Renal cell carcinoma
    477575 (MAPK1)
   05219 Bladder cancer
    477575 (MAPK1)
   05215 Prostate cancer
    477575 (MAPK1)
   05213 Endometrial cancer
    477575 (MAPK1)
   05224 Breast cancer
    477575 (MAPK1)
   05223 Non-small cell lung cancer
    477575 (MAPK1)
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    477575 (MAPK1)
   05170 Human immunodeficiency virus 1 infection
    477575 (MAPK1)
   05161 Hepatitis B
    477575 (MAPK1)
   05160 Hepatitis C
    477575 (MAPK1)
   05171 Coronavirus disease - COVID-19
    477575 (MAPK1)
   05164 Influenza A
    477575 (MAPK1)
   05163 Human cytomegalovirus infection
    477575 (MAPK1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    477575 (MAPK1)
   05165 Human papillomavirus infection
    477575 (MAPK1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    477575 (MAPK1)
   05135 Yersinia infection
    477575 (MAPK1)
   05133 Pertussis
    477575 (MAPK1)
   05152 Tuberculosis
    477575 (MAPK1)
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    477575 (MAPK1)
   05140 Leishmaniasis
    477575 (MAPK1)
   05142 Chagas disease
    477575 (MAPK1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    477575 (MAPK1)
   05020 Prion disease
    477575 (MAPK1)
   05022 Pathways of neurodegeneration - multiple diseases
    477575 (MAPK1)
  09165 Substance dependence
   05034 Alcoholism
    477575 (MAPK1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    477575 (MAPK1)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    477575 (MAPK1)
   04933 AGE-RAGE signaling pathway in diabetic complications
    477575 (MAPK1)
   04934 Cushing syndrome
    477575 (MAPK1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    477575 (MAPK1)
   01524 Platinum drug resistance
    477575 (MAPK1)
   01522 Endocrine resistance
    477575 (MAPK1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    477575 (MAPK1)
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins [BR:cfa03036]
    477575 (MAPK1)
  09183 Protein families: signaling and cellular processes
   04147 Exosome [BR:cfa04147]
    477575 (MAPK1)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.24  mitogen-activated protein kinase
     477575 (MAPK1)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: CMGC group
  MAPK family [OT]
   477575 (MAPK1)
Chromosome and associated proteins [BR:cfa03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     477575 (MAPK1)
Exosome [BR:cfa04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   477575 (MAPK1)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr ABC1 APH Haspin_kinase Choline_kinase FTA2 Kdo
Other DBs
NCBI-GeneID: 477575
NCBI-ProteinID: NP_001104270
Ensembl: ENSCAFG00000015421
VGNC: 42991
UniProt: A0A8C0TIJ2 A0A8I3PZP0
Position
26:complement(30970465..31089387)
AA seq 360 aa
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
NT seq 1083 nt   +upstreamnt  +downstreamnt
atggcggcggcggcggcggcgggcgcgggcccggagatggtccgcgggcaggtgttcgac
gtggggccgcgctacaccaacctctcctacatcggcgagggcgcctacggcatggtgtgc
tctgcttatgataatgtcaacaaagttcgagtagccatcaagaaaatcagtccttttgag
caccagacctactgccagagaaccctgagggagataaaaatcttactgcgcttcagacat
gagaacatcattggaatcaatgatattattcgagcaccaaccatcgagcaaatgaaagat
gtatatatagtacaagacctcatggaaacagatctttacaagctcttgaagacgcaacac
ctcagcaacgaccatatctgctattttctttaccagatcctcagagggttaaaatatatc
cattcagctaatgtactgcaccgtgacctcaaaccttccaacctgctgctcaataccacc
tgcgatctcaagatctgtgactttggcttggcccgtgttgcagatccggatcatgatcac
acagggttcctgacggagtatgtagccacacgttggtacagggctccagaaattatgttg
aattccaagggctataccaagtccattgatatttggtctgtaggctgcattctggcagag
atgctgtccaacaggcccatcttcccggggaagcattatctcgaccagctgaaccacatt
ttgggtattcttggatccccatcacaggaagacctgaactgtataataaatttaaaagct
agaaactacttgctttctcttccacacaaaaataaggtgccatggaacaggctgttccca
aatgctgactcgaaagctctggatttactggacaaaatgttgacattcaaccctcacaag
aggattgaagtagaacaggctctggcccatccgtatctggagcagtattatgacccaagt
gatgagcccatcgctgaggcgccattcaagtttgacatggagctagatgacctgcccaag
gaaaagctcaaggagctcatcttcgaagagacagctagattccagccgggatacagatct
taa

  All links  
Ontology (5)   
   KEGG BRITE (5)   
Pathway (116)   
   KEGG PATHWAY (116)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (21)   
   KEGG ORTHOLOGY (1)   
   RefGene (15)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (3)   
   UniProt (2)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (8)   
   Pfam (8)   
All databases (156)   

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