KEGG   Canis lupus familiaris (dog): 477692
Entry
477692            CDS       T01007                                 
Symbol
LRP6
Name
(RefSeq) low-density lipoprotein receptor-related protein 6
  KO
K03068  low density lipoprotein receptor-related protein 5/6
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04150  mTOR signaling pathway
cfa04310  Wnt signaling pathway
cfa04928  Parathyroid hormone synthesis, secretion and action
cfa05010  Alzheimer disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05200  Pathways in cancer
cfa05224  Breast cancer
cfa05225  Hepatocellular carcinoma
cfa05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04310 Wnt signaling pathway
    477692 (LRP6)
   04150 mTOR signaling pathway
    477692 (LRP6)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    477692 (LRP6)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    477692 (LRP6)
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    477692 (LRP6)
   05226 Gastric cancer
    477692 (LRP6)
   05224 Breast cancer
    477692 (LRP6)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    477692 (LRP6)
   05022 Pathways of neurodegeneration - multiple diseases
    477692 (LRP6)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    477692 (LRP6)
Membrane trafficking [BR:cfa04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Low-density lipoprotein receptor (LDLR) family proteins
    477692 (LRP6)
SSDB
Motif
Pfam: Ldl_recept_b FXa_inhibition Ldl_recept_a DUF5050 SGL cEGF EGF
Other DBs
NCBI-GeneID: 477692
NCBI-ProteinID: XP_013964029
Ensembl: ENSCAFG00000013324
VGNC: 42778
UniProt: A0A8C0NS55 A0A8I3Q1I5
Position
27:complement(12280309..12442407)
AA seq 1613 aa
MGAVLRSLLACSFCALLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVF
GHGLIYWSDVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIE
VSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFVIINTE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDTLYWT
DWNTHSILACNKYTGEGLREIHSNIFSPMDIHAFSQQRQPNATNPCGIDNGGCSHLCLMS
PVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWT
DTGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSD
RVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTL
LGDYVYWTDWQRRSIERVHKRSAEREIIIDQLPDLMGLKATNVHRIIGSNPCAEENGGCS
HLCLYRPQGLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISLETNNNNVAIPLTG
VKEASALDFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDYPEGMAVDWLGKNLY
WADTGTNRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDG
SERTTLVPNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVIADDLPHPFGLTQ
YQDYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQAGWNECASSNGHC
SHLCLAVPVGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAINRMVIDEQQSPDIILP
IHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVVVSSVPNQNLEIQPYDLS
IDIYSRYIYWTCEATNVINVTRLDGRSIGVVLKGEQDRPRAIVVNPEKGYMYFTNLQERS
PKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIESSDLSGANRIVLE
DSNILQPVGLTVFENWLYWIDKQQQMIEKIDMTGREGRTKVQARIAQLSDIHAVKELNLQ
EYRQHPCAQDNGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGE
IDCIPVAWRCDGFTECEDHSDELNCPVCSESQFQCASGQCIDGALRCNGDANCQDKSDEK
NCEVLCLIDQFRCSNGQCIGKHKKCDHNVDCSDKSDELDCYPTEEPAPQATNTVGSVIGV
IVTIFVSGTIYFICQRMLCPRMKGDGETMTNDYVVHGPASVPLGYVPHPSSLSGSLPGMS
RGKSMISSLSIMGGSSGPPYDRAHVTGASSSSSSSTKGTYFPAILNPPPSPATERSHYTM
EFGYSSNSPSTHRSYSYRPYSYRHFAPPTTPCSTDVCDSDYAPSRRMTSVATAKGYTSDL
NYDSEPVPPPPTPRSQYLSAEENYESCPPSPYTERSYSHHLYPPPPSPCTDSS
NT seq 4842 nt   +upstreamnt  +downstreamnt
atgggggccgtcctgaggagcctcctggcctgcagtttctgtgcgctcctgagagcggcc
cctttgttgctttatgcaaacagacgggacttgcgattggttgatgctacaaatggcaaa
gagaatgctacaattgtagttggaggcttggaggatgcagctgcggtggactttgtgttt
ggtcatggcttgatatactggagtgatgtcagcgaagaagccattaaacgaacagaattt
aacaaaactgagagtgtacagaatgttgttgtctctggattattgtcccctgatgggctg
gcatgtgattggcttggagaaaaattatactggacagattctgaaacaaatcggattgaa
gtttctaatttagatggatctttacgaaaagttttattttggcaagagttggatcaaccc
agagctattgccttagatccttcaagtgggttcatgtactggacagactggggagaagta
ccaaagatagaacgtgctggaatggatggttcaagtcgcttcgttataataaacactgaa
atttactggccaaatggactgactttggattatgaggaacagaagctttactgggcagat
gcaaaactcaatttcatccacaaatcaaatctggatggaacaaatcggcaggcagtggtt
aaaggttctcttccacatccttttgccttgacattatttgaggacacattgtactggact
gactggaacacacactccattttggcttgcaacaagtacactggcgagggtctgcgtgaa
atccattctaacatcttctctcccatggatatacatgccttcagccaacagagacagcca
aatgctacaaatccatgtggaattgataatggtggttgttcccacttatgtttgatgtct
ccagtcaagcctttttatcagtgtgcttgcccaactggggtcaaactcctggagaatgga
aaaacctgcaaagatggtgccactgaattactgcttttagcacgaaggacagacttgaga
cgtatttctttggatacgccagattttacggacattgttttacagttagaagacatccgt
catgccattgccatagattatgatcctgtggaaggctatatctactggactgatgatgaa
gtgagggccatacgccgctcattcatagatggatctggcagtcagtttgtggtcaccgct
caaattgcacatcctgatggcattgctgttgactgggttgcccgaaatctttattggaca
gatactggcactgatcggatagaagtgacaaggctcaatggtaccatgaggaagatcttg
atttcagaggacttagaggaaccccgggctattgtgttagatcccatggttgggtacatg
tattggactgactggggagaaatcccgaaaattgagcgagcagctctggatggttctgac
cgagtagtgttggttaatacttctcttggttggccaaatggtttagccttggattatgat
gaaggcaaaatatactggggagatgccaaaacagacaaaattgaggttatgaatactgat
ggcactgggagacgagtactagtggaagataaaattcctcacatatttgggtttactttg
ttgggtgactatgtttactggactgactggcagaggcgtagcatcgaaagagtacacaaa
cgaagtgcagaaagggaaatcatcatagatcagcttcctgacctcatgggcctaaaggcc
acaaatgttcatcgaatcattggttccaacccctgtgctgaggaaaatgggggatgtagc
catctttgcctctataggcctcagggcctccgctgtgcctgccccattggctttgaactc
atcagtgacatgaaaacctgcattgtcccagaggctttccttttgttttcacggagagca
gatattaggcgaatttctttggaaactaacaataataatgtggccattcctctcactggt
gtcaaagaagcttctgctttggattttgatgtaactgacaaccgcatttactggaccgat
atatcactcaagaccatcagcagagcctttatgaatggcagtgcactggaacatgtggta
gaattcggcttggattacccagaaggcatggcagtagactggctcggaaagaacttgtac
tgggctgacacaggaacgaatcgaattgaggtgtcaaagctagacgggcagcaccgacag
gttttggtgtggaaagacctagatagtcccagagctcttgcactggaccctgctgaagga
tttatgtattggactgaatggggtggaaaacctaagatagacagagctgccatggatgga
agtgaacgtactacattagttccaaatgtggggcgggcaaatggcctaactattgattat
gctaaaaggaggctttattggacagacctggacactaacttaatagaatcttcgaatatg
cttggactcaaccgtgaagttatagcagatgatttgcctcatccttttggcttaactcag
taccaagattacatctactggaccgattggagccgacgcagcattgaacgtgccaacaaa
accagtggccaaaaccgcaccatcattcagggccatttggattatgtgatggacatcctc
gtctttcactcctctcggcaggcgggctggaatgagtgtgcttccagcaatgggcactgc
tcccacctctgcttggctgttccagtaggaggttttgtttgtggatgtcctgcccactac
tctcttaatgccgacaacaggacttgtagtgctccaactactttcctgctcttcagtcaa
aagagtgccatcaaccgcatggtgattgatgagcagcagagccctgacatcatccttcct
atccacagtcttcggaatgtccgggccattgattatgacccactggacaagcaactctat
tggattgactcacgacaaaacatgatccgaaaagcacaagaagatggcagccagggcttt
actgtggttgtgagctcagttccaaatcagaacctagaaatacaaccctatgacctcagc
attgatatttatagccgctacatttactggacttgtgaggccaccaatgtcattaatgta
acaagattagatgggagatcaattggagtggtactgaaaggcgagcaagacagacctcga
gccattgtggtaaacccggagaaggggtatatgtattttaccaatcttcaggaaaggtct
cccaaaattgaacgggctgctttggatggaacagaacgggaggtcctctttttcagtggc
ttaagtaaaccaattgctttagcccttgatagcagattgggcaagcttttttgggcagat
tcagatctccggcgaattgaaagcagtgatctctcaggtgccaaccgaatagtattagaa
gactccaatatcttgcagcctgtgggactgactgtgtttgaaaactggctatattggatt
gataagcagcagcaaatgattgaaaaaattgacatgacaggccgagagggtagaaccaaa
gtccaggctcgaattgcccagcttagtgacattcatgctgtgaaagagctgaaccttcag
gaatatagacagcacccttgcgctcaggataatggtggctgttcacatatttgtcttgtg
aaaggagatggtactacaaggtgctcttgccccatgcacttggttctgcttcaagatgag
ctgtcctgtggagaacccccaacatgttctcctcagcagtttacttgtttcacgggagaa
attgactgtatccctgtggcttggcggtgcgatgggtttactgaatgtgaagaccacagt
gatgagctcaattgccctgtttgctcagagtcccaattccagtgtgccagtgggcagtgt
attgatggtgccctccgatgcaatggagatgcaaactgccaggataaatcagatgagaag
aactgtgaagtgctgtgtttaattgatcagttccgctgttccaacggtcagtgcattgga
aaacataagaaatgtgatcataatgtggattgcagtgacaaatcagatgaactggattgt
tatccaactgaggaaccagctccacaggccaccaatacagttggttcagttattggagta
attgtcaccatttttgtgtctggaacaatatactttatctgccagagaatgttgtgtcca
cgtatgaagggagatggggaaaccatgactaacgattatgtagttcatggaccagcttct
gtgccccttggttatgtgccacatccaagttctttgtcaggatctcttccaggaatgtct
cgaggtaaatcaatgatcagctccctaagtatcatggggggaagcagtggacccccttat
gaccgagctcatgtcacaggagcatcatcaagtagttcttcaagcaccaaaggcacttac
ttccctgcaattttgaaccctccgccatccccagccacagagcgatcgcattatactatg
gaatttggttattcttcaaatagtccttccactcataggtcctacagctacaggccatat
agttaccggcactttgcacccccgaccacaccctgcagcacagacgtttgtgacagtgac
tatgctcccagccgaagaatgacctcagtggcaacagccaagggctacactagtgacttg
aactatgactcagagcctgtgcccccacctcccacaccccgaagccaatacctgtcagca
gaagagaactatgaaagctgtccaccttctccatacacagagaggagctactctcatcac
ctctacccaccgccgccctctccctgtacagactcctcctga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (9)   
   KEGG PATHWAY (9)   
Genome (1)   
   KEGG GENOME (1)   
Gene (13)   
   KEGG ORTHOLOGY (1)   
   RefGene (7)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (7)   
   UniProt (2)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (7)   
   Pfam (7)   
All databases (44)   

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