KEGG   Canis lupus familiaris (dog): 478257
Entry
478257            CDS       T01007                                 
Symbol
EIF2AK4
Name
(RefSeq) eIF-2-alpha kinase GCN2 isoform X12
  KO
K16196  eukaryotic translation initiation factor 2-alpha kinase 4 [EC:2.7.11.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04140  Autophagy - animal
cfa05160  Hepatitis C
cfa05162  Measles
cfa05168  Herpes simplex virus 1 infection
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    478257 (EIF2AK4)
 09160 Human Diseases
  09172 Infectious disease: viral
   05160 Hepatitis C
    478257 (EIF2AK4)
   05162 Measles
    478257 (EIF2AK4)
   05168 Herpes simplex virus 1 infection
    478257 (EIF2AK4)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    478257 (EIF2AK4)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     478257 (EIF2AK4)
Protein kinases [BR:cfa01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   478257 (EIF2AK4)
SSDB
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RWD HGTP_anticodon2 tRNA-synt_His Kinase-like Kdo ABC1 PIEZO
Other DBs
NCBI-GeneID: 478257
NCBI-ProteinID: XP_005638286
Ensembl: ENSCAFG00000008775
VGNC: 40259
UniProt: A0A8P0NU27
Position
30:7199521..7302773
AA seq 1600 aa
MAGGRGAPGRGRDEPPESYPQRQEHELQALEAIYGADFQDLRPDARKSVNEPPEINLVLY
PQGLTGEEVYVQVDLRVKCPPTYPDVVPEIELKNAKGLSNESVHLLKSHLEKVAKKHCGE
QREILHEIQRRKEEIKEERKRKEMAKQERLEIASLSNQDQNSRKDPGGHRISAILHGGSP
DFVGNGKHRTNSSGRSRRERQYSLCSSEDSSGSCEVLYFSMGSPDQLMVYKGRCIGSDEQ
LGKLVYNALETATGNFVSLHEWVLRWQKKMGPFLTSQEKEKIDKCKKQIQGAETEFNSLV
KLSHPNVVRYFAMNLKEQDDSIMVDILLEHINGVSLSAHLSHSGPIPVYQLRKYTAQLLS
GLDYLHSNDVVHKVLNASNVLVDAEGNVKITDYSISKRLADICKEDVFEQSRVSFSDSAL
PYKTGKKGDVWCLGLLLLFLSQGQECGEYPVTIPSDLPADFQDFLKKCVCLDDKERWSPQ
QLLKHSFINPQPKMSLLEQSPDDSGGQDYVETVIPSKQLPSAAFFSETQRQFSRYFIEFE
ELQLLGKGAFGAVIKVQNKLDGCCYAVKRIPINPASRHFRRIKGEVTLLSRLHHENIVRY
YNAWIERYERPVGPGMLPQDSDSWPQAPDGRALSQPSPGNDSPDGDGAGSVEAAAPPPIL
SSVEWSTSGERSASARFPSARPGSSSEEDDDDDEHEGVFSQPFLPASDSDSDVIFEDENS
KSQNQEEDCNGKNSCHESEPSTTTEAVHYLYIQMEYCEKSTLRDTIDQGLYQDTIRLWRL
FREILDGLAYIHEKGMIHRDLKPVNIFLDSDDHVKIGDFGLATDHLAFTADGKQDDTADH
LIKSDPSGHLTGMVGTALYVSPEVQGSSRPTYNQKVDLFSLGIIFFEMSYHPMVTASERI
FVLNQLRDPTSPKFPEDFDDGEHTKQKSVISWLLNHDPAKRPTATELLKSELLPPPQMEE
SELHEVLHHTLANVDGKAYRTMMAQIFSQRVSPAIDYTYDSNMPKGFSIRTSKIQQHVCD
TIVRIFKKHGAVQLCTPLLLPQNRQIYEHNEAALFMDHSGMLVMLPFDLRVPFARYVARN
NILNLKRYCIERVFRPRKLDRFHPKELLECAFDIVTSTTNSSLPTAEVIYTICEIIQEFP
ALQERNYSIYLNHTMLLKAIFLHCGIPEDKLSQVYVILYDAVTEKLTRREVEAKFCNLSL
SSNSLCRLYKFIEQKGDLQDLTPAINSLIKQKTGVAQLVKYGLKDLEEIIGLLKKLGIKL
QVLINLGLVYKVQQHNGVIFQFVAVIRRRQRAISEILAAGGRYDLLIPQFRGPQALGPVP
TAVGVSIAIDKISAAILNMEEPVTISSCDLLIVSVGQMSMSRAINLTQKLWSAGITAQIM
YDWSQSQEELQEYCRYHEITYVALVSDKGGSYVKVKSFEKERQTEKLVQESDLIDHVLQK
LRTKVSDERTIREASDNLAVQNLKGSFSNASGLFEIHGAAVVPIVSVIAPEKLSASTRRR
YETQVQTRLQTSLANLHQKSNEIEILAVDLPKETILQFLSLEWDADEQAFNTTVKQLLSR
LPKQRYLKLVCDEIYNIKVEKKVSVLFLYSYRDDYYRILF
NT seq 4803 nt   +upstreamnt  +downstreamnt
atggctgggggccgtggggcccccgggcgcggccgggacgagcctccggagagctacccg
cagcggcaggagcacgagctgcaggccctggaggccatctacggcgccgacttccaggac
ctgcggccggacgcgcgcaaatcggtcaacgagccccctgaaatcaacttagttctgtac
cctcagggcctaactggtgaagaagtatacgtgcaagtggatttgagggttaaatgccca
ccaacctacccagatgtagtccctgaaatagagttaaagaatgccaaaggtctatcaaat
gaaagtgttcatttgttaaaatcccacctagagaaagtggccaaaaaacattgtggagag
caacgtgaaatccttcatgagattcaaagaaggaaagaagagataaaagaagagagaaaa
agaaaagaaatggctaagcaggagcgtttggaaattgctagtttgtcaaaccaagatcaa
aactctaggaaagacccaggaggacacagaatatctgccattctacatggaggctctcct
gactttgtaggaaatggtaaacatcggaccaactcctctggaaggtctaggcgagaacgt
cagtattctctgtgtagtagtgaagattcttctggctcttgtgaagtcctgtatttctct
atgggtagccctgatcagctcatggtttacaaagggaggtgcattggcagtgatgagcag
cttggaaaattagtttataatgctttggaaacggccactggcaactttgtgtcattacat
gagtgggtccttcggtggcagaaaaaaatgggcccgttccttaccagtcaagagaaggag
aagattgataagtgcaaaaagcagattcaaggggcagaaacggaattcaactcactggta
aaattgagccatccaaatgtagtacgctactttgcaatgaatctcaaagagcaagatgac
tccatcatggtggacattttattggagcacattaatggggtctccctctctgcacatctg
agccactcaggccccatccctgtgtatcaactccgcaagtacacagctcagctcttgtct
ggcctcgattatttgcacagcaatgacgtggtgcacaaggttctgaatgcatcaaatgtc
ttggtggatgcagagggcaatgtcaagattacggactacagcatttcaaagcgcctagca
gacatttgcaaggaggatgtgtttgagcagagccgagttagttttagtgacagtgcccta
ccttataaaacggggaagaaaggggatgtttggtgtcttggccttctgctgctcttcctc
agccaaggacaagaatgcggagagtaccctgtgaccatccctagcgacttaccagctgac
ttccaagattttctaaagaagtgtgtttgcttggatgacaaggaaagatggagtccccag
caattgttgaaacacagctttatcaatccacagccgaaaatgtctttattggaacagagt
cctgacgattctggaggacaagattatgttgagactgttattcctagtaagcagctaccc
agtgcagcattcttcagtgagacacagagacagttttcccggtatttcattgagtttgaa
gaattacagcttctcggcaaaggagccttcggagctgtcatcaaggtgcagaacaagctg
gatggctgctgctacgcggtgaagcgcatccccatcaatccggccagtaggcatttccgc
aggatcaagggcgaggtgacgctgctgtcgcgcctgcaccacgagaacatagtgcgctac
tataacgcctggatagagagatacgagcggcccgtgggcccggggatgctgccgcaggac
tcggactcatggccccaggcaccggatgggcgagctttgtcccagccgtccccaggcaac
gacagccccgacggcgacggcgccggtagcgtggaggccgctgcgccaccgcccatcctc
agctcggtggagtggagcacatctggcgagcgttcggccagcgcccgcttcccctccgcc
cgcccaggctccagcagcgaggaggacgacgacgacgacgagcacgagggcgtcttctcc
cagcccttcctacctgcttcagattctgacagtgatgtcatctttgaagatgagaacagt
aagagtcagaatcaggaagaagactgcaatgggaagaacagttgccatgaaagtgagcca
tcgacaaccactgaagctgtgcactacctgtatatccagatggagtactgtgagaagagt
actttgcgtgacaccattgaccaggggctatatcaagataccatcagactctggaggctt
tttcgagagattctggatggattagcttatatccatgaaaaaggaatgattcaccgggat
ttgaagcctgtcaacatctttttggattctgatgaccatgtaaaaataggtgattttggt
ttagcgacagaccatcttgccttcactgctgatggcaagcaagatgatacagcagatcac
ttgattaaatcagacccctcaggtcatttgactgggatggttggtactgctttatacgta
agcccagaggtccaaggaagcagcagacccacgtacaaccagaaagtggatctcttcagc
ctgggaattatcttctttgagatgtcctatcaccccatggtcacggcctcagaaaggatc
tttgttctcaaccaactcagagatcccacttcacctaagtttccagaagacttcgatgat
ggagagcatacaaagcagaaatctgtcatctcctggctgttgaaccatgatcccgccaag
cggcccacagccacagagctgctcaagagtgagctgctgcccccaccccagatggaggag
tcagagttgcatgaggttctgcaccacaccctggccaacgtggatgggaaggcctaccgc
accatgatggcccagatcttctcccagcgcgtcagtccagccatcgattacacctatgac
agcaacatgccgaagggcttttcaatccgtacatccaagatacagcaacatgtgtgtgat
accatcgtccgcatttttaaaaaacacggagctgtccagttgtgtactccactactgctt
ccccaaaataggcaaatatacgagcacaatgaagctgccttattcatggaccacagcggg
atgctggtgatgcttccctttgacctacgggttccttttgcaagatatgtggcaagaaat
aatatattgaatttgaaacgttactgcatagaacgtgtcttcagacctcgcaagttagac
cgatttcatcccaaagaacttctggaatgtgcatttgacattgttacgtctaccaccaac
agctctctgcccactgctgaagtcatctacacgatctgtgagatcatccaggagttcccg
gcactgcaggaaagaaattacagtatttacttgaaccacaccatgttattgaaagcaatc
ttcttacactgtgggatcccagaagataaactcagtcaagtctatgttattctatatgat
gcagtgacagaaaagctgacaaggagagaagtggaagccaagttttgtaatctgtctctg
tcatctaatagtctgtgtcgactctacaaattcattgagcagaagggagatttgcaagat
ctaacaccagcaataaattcattaataaaacagaaaacaggtgttgcccaactggtgaag
tatggcttgaaagacttagaggagatcattgggctgttgaagaaactcggcatcaagtta
caggtcttgatcaacttgggcttggtttacaaagtacagcagcacaacggagtcatcttc
cagtttgtggcggtcatcagacggaggcaaagggctatttcagaaatccttgcagctgga
ggcagatacgacctgctgattccccagtttagaggaccgcaggctctgggaccagtcccg
actgctgttggggtcagcatagccatagacaagatatctgcagctatcctcaacatggaa
gaacctgttacaataagctcttgtgacctcctgatcgtaagtgttggccagatgtccatg
tccagggccatcaacctaacccagaaactttggtcagcaggaatcacagcacagatcatg
tacgactggtcacagtcccaagaagaactccaggaatactgcagataccacgaaatcacc
tacgtggccctcgtctcagataaaggaggaagctatgtcaaggttaagtcttttgagaag
gaaaggcaaacagagaaacttgtgcaggagtctgatcttatagaccacgttttgcagaaa
ctcagaactaaagtcagtgatgaaaggactatcagagaagcttctgataatctcgcagtg
caaaatctgaaggggtccttttctaatgcttcaggtttgtttgaaatccacggagcagca
gttgtccccattgtgagcgtgatagccccagagaagctgtcagccagcacgaggaggcgt
tatgaaactcaggtacaaacacgacttcagacctcccttgccaacttacatcagaaaagc
aatgaaattgaaattttggctgtggatctacccaaagaaacaatcttacagtttttatcg
ttagagtgggatgctgatgaacaggcatttaacacaactgtgaagcagctgctgtcacgc
ctgccaaagcagagatacctcaaattagtctgtgatgaaatttataacatcaaagtagag
aaaaaggtatctgtgctattcctgtatagctacagagatgactactaccgaatcttattt
taa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (33)   
   KEGG ORTHOLOGY (1)   
   RefGene (27)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (14)   
   UniProt (1)   
   RefSeq(pep) (13)   
DNA sequence (13)   
   RefSeq(nuc) (13)   
Protein domain (9)   
   Pfam (9)   
All databases (78)   

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