KEGG   Canis lupus familiaris (dog): 480348
Entry
480348            CDS       T01007                                 
Symbol
HIF1A
Name
(RefSeq) hypoxia-inducible factor 1-alpha
  KO
K08268  hypoxia-inducible factor 1 alpha
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04066  HIF-1 signaling pathway
cfa04137  Mitophagy - animal
cfa04140  Autophagy - animal
cfa04148  Efferocytosis
cfa04659  Th17 cell differentiation
cfa04919  Thyroid hormone signaling pathway
cfa05167  Kaposi sarcoma-associated herpesvirus infection
cfa05200  Pathways in cancer
cfa05205  Proteoglycans in cancer
cfa05208  Chemical carcinogenesis - reactive oxygen species
cfa05211  Renal cell carcinoma
cfa05230  Central carbon metabolism in cancer
cfa05231  Choline metabolism in cancer
cfa05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    480348 (HIF1A)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    480348 (HIF1A)
   04137 Mitophagy - animal
    480348 (HIF1A)
   04148 Efferocytosis
    480348 (HIF1A)
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    480348 (HIF1A)
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    480348 (HIF1A)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    480348 (HIF1A)
   05205 Proteoglycans in cancer
    480348 (HIF1A)
   05208 Chemical carcinogenesis - reactive oxygen species
    480348 (HIF1A)
   05230 Central carbon metabolism in cancer
    480348 (HIF1A)
   05231 Choline metabolism in cancer
    480348 (HIF1A)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    480348 (HIF1A)
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    480348 (HIF1A)
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    480348 (HIF1A)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors [BR:cfa03000]
    480348 (HIF1A)
Transcription factors [BR:cfa03000]
 Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    480348 (HIF1A)
SSDB
Motif
Pfam: PAS_3 PAS_11 HIF-1a_CTAD PAS HIF-1 PAS_9 PAS_4 HLH DDRGK
Other DBs
NCBI-GeneID: 480348
NCBI-ProteinID: NP_001274092
Ensembl: ENSCAFG00000015718
VGNC: 41686
UniProt: A0A8C0QCT6 A0A8I3PI05 Q6SLL1
Position
8:36366891..36409562
AA seq 823 aa
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
RLTISYLRVRKLLDAGDLDIEDEMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYM
GLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQSQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSK
TFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQV
TTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTET
DDQQLEEVPLYNDVMLPSSNEKLQNINLAMSPLPASETPKPLRSSADPALNQEVALKLEP
NPESLELSFTMPQIQDQPASPSDGSTRQSSPEPNSPSEYCFDVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESNSTSPQSASTITVFQ
PTPMQEPPLTTTSTTATTDELKTVTKDGIEDIKILIAAPSPTHVPKVTTSATTSPYSDTG
SRTASPNRAGKGVIEQTEKSHPRSPNVLSVTLSQRTTIPEEELNPKILALQNAQRKRKIE
HDGSLFQAVGIGTLLQQPDDRATTTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLL
GQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN
NT seq 2472 nt   +upstreamnt  +downstreamnt
atggagggcgccggcggcgcgaacgacaagaaaaaaataagttctgaacgtcgaaaagaa
aagtctagagatgcagccagatctcggagaagtaaagagtctgaagttttttacgagctt
gctcatcagttgccacttcctcataatgtgagctcgcatcttgataaggcttctgttatg
aggcttaccatcagctatttgcgtgtaaggaagcttctggatgctggtgacttagatatt
gaagatgaaatgaaggcacagatgaattgcttttatttgaaagccctggatggttttgtt
atggttctcacagatgatggtgacatgatttacatttctgataatgtgaacaaatacatg
ggattgactcagtttgaactaactggacacagtgtgtttgattttactcatccatgtgac
catgaggaaatgagagaaatgcttacacacagaaatggccttgtgaaaaagggtaaagag
cagaatacacagcgaagtttttttctcagaatgaagtgtaccctaactagccgggggaga
actatgaacatcaagtcagcaacatggaaagtacttcactgcacaggccacattcatgtc
tacgatactaatagtaaccaatctcagtgtgggtataagaaaccacccatgacgtgcttg
gtgctgatttgtgaacccattcctcatccatcaaatattgaaattcctttagatagcaag
acttttctcagtcgtcacagtctggatatgaaattttcttattgtgatgaaagaattact
gaattgatgggatatgagccagaagaacttttgggccgctcaatatatgaatattatcat
gctttggactctgaccatctgaccaaaactcatcatgatatgtttactaaaggacaagtc
accacaggacagtacaggatgcttgccaaaagaggtggttatgtctgggttgaaactcaa
gcaactgtcatatataacactaagaactctcaaccacagtgcattgtatgtgtaaattat
gttgtgagtggtattattcagcacgacttgattttctcccttcaacaaacagaatgtgtc
ctcaaaccagttgaatcttcagatatgaaaatgactcagctattcaccaaagttgaatca
gaagatacaagtagtctctttgataagcttaaaaaggaacctgatgctttaactttgctg
gccccagctgctggagacacaatcatatctttagatttcggcagcaatgacacagaaact
gatgaccaacaacttgaggaagttccgttgtataatgatgtaatgctcccctcatccaac
gaaaaattacagaatataaatttggcaatgtctccattacctgcttctgaaactccaaag
ccacttcgaagtagtgctgacccggcactcaatcaagaagttgcgttaaaattagagcca
aatccagagtcactggaactttcttttactatgccccagattcaagatcagccagctagt
ccttctgatggaagcactagacaaagttcacctgagcccaacagtcccagtgaatattgt
tttgatgtggatagtgatatggtcaatgaatttaagcttgaattggtagagaaacttttt
gctgaagacacagaagcaaagaatccattttccacccaggacactgatttagacttggag
atgttagctccttatatcccaatggatgatgacttccagttacgttccttcgatcagttg
tcaccactggaaagcaattctacaagtcctcaaagtgcgagcacaattacagtattccag
ccgactccaatgcaagaacctcctcttactactaccagtaccactgctaccactgatgaa
ttaaaaacagtgacaaaagatggcatagaagacattaaaatattgattgcagctccatct
cctacccatgtacctaaagtaactactagtgccacaacatcaccatacagtgatactgga
agtcggacagcctcaccaaacagagcaggaaaaggagtaatagaacagacggaaaaatct
catccaagaagccctaacgtgttatctgtcactttgagtcaaagaactaccattcctgag
gaagaattaaatccaaagatactagctttgcagaatgcgcagagaaagcgaaaaatagaa
catgacggttcactttttcaagcagtaggaattggaacattattacagcagccagatgat
cgtgcaactactacatcactttcttggaaacgcgtaaaaggatgcaagtctagtgaacag
aatggaatggagcaaaagacaattattttaataccttctgatttagcgtgtagactgctg
gggcaatcaatggatgagagtggattaccacaactgaccagttatgattgtgaagttaat
gctcctatacaaggcagcagaaacctactgcagggtgaagaattactcagagctttggat
caagttaactga

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (14)   
   KEGG PATHWAY (14)   
Genome (1)   
   KEGG GENOME (1)   
Gene (18)   
   KEGG ORTHOLOGY (1)   
   RefGene (12)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (4)   
   UniProt (3)   
   RefSeq(pep) (1)   
DNA sequence (17)   
   RefSeq(nuc) (1)   
   GenBank (8)   
   EMBL (8)   
Protein domain (9)   
   Pfam (9)   
All databases (65)   

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