KEGG   Canis lupus familiaris (dog): 482620
Entry
482620            CDS       T01007                                 
Symbol
APAF1
Name
(RefSeq) apoptotic protease-activating factor 1 isoform X1
  KO
K02084  apoptotic protease-activating factor
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa01524  Platinum drug resistance
cfa04115  p53 signaling pathway
cfa04210  Apoptosis
cfa04215  Apoptosis - multiple species
cfa05010  Alzheimer disease
cfa05012  Parkinson disease
cfa05014  Amyotrophic lateral sclerosis
cfa05016  Huntington disease
cfa05020  Prion disease
cfa05022  Pathways of neurodegeneration - multiple diseases
cfa05134  Legionellosis
cfa05152  Tuberculosis
cfa05160  Hepatitis C
cfa05161  Hepatitis B
cfa05162  Measles
cfa05164  Influenza A
cfa05168  Herpes simplex virus 1 infection
cfa05169  Epstein-Barr virus infection
cfa05200  Pathways in cancer
cfa05222  Small cell lung cancer
cfa05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    482620 (APAF1)
   04215 Apoptosis - multiple species
    482620 (APAF1)
   04115 p53 signaling pathway
    482620 (APAF1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    482620 (APAF1)
  09162 Cancer: specific types
   05222 Small cell lung cancer
    482620 (APAF1)
  09172 Infectious disease: viral
   05161 Hepatitis B
    482620 (APAF1)
   05160 Hepatitis C
    482620 (APAF1)
   05164 Influenza A
    482620 (APAF1)
   05162 Measles
    482620 (APAF1)
   05168 Herpes simplex virus 1 infection
    482620 (APAF1)
   05169 Epstein-Barr virus infection
    482620 (APAF1)
  09171 Infectious disease: bacterial
   05134 Legionellosis
    482620 (APAF1)
   05152 Tuberculosis
    482620 (APAF1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    482620 (APAF1)
   05012 Parkinson disease
    482620 (APAF1)
   05014 Amyotrophic lateral sclerosis
    482620 (APAF1)
   05016 Huntington disease
    482620 (APAF1)
   05020 Prion disease
    482620 (APAF1)
   05022 Pathways of neurodegeneration - multiple diseases
    482620 (APAF1)
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    482620 (APAF1)
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    482620 (APAF1)
SSDB
Motif
Pfam: WD40 APAF1_C NB-ARC APAF-1-like_WHD ANAPC4_WD40 CARD NBCH_WD40 RMC1_N eIF2A WD40_like Ge1_WD40 Nup160 CARD_2 AAA_16 Utp8 Hira AAA_18 AAA_22 ATPase_2 NACHT
Other DBs
NCBI-GeneID: 482620
NCBI-ProteinID: XP_022259091
Ensembl: ENSCAFG00000006556
VGNC: 54194
Position
15:38408276..38554051
AA seq 1262 aa
MDAKARNCLLQYREALEKDIKTSYIMDRMINDGVLTISEEEKVKNEPTQQQRAALLIKTI
LKKDNYSYISFYNALIHEGYKDLAALLHSGIPVISSSNGGKDSVGGITSHVKTVLCEGGV
PQRPVVFVTRKKLVNAIRQNLFKLSDEPGWVVIYGMAGCGKSVLAAEAVRDHFFLDGCFP
GGVHWVSVGKQDKAGLLMKLQNLCTRLDQDENFSQRPPLNIEEAKDRLRLLMLRKHPRSL
LILDDIWDSWILKAFDNQCQILLTTRDKSVTDSVMGPKYIVAVESDLGKEKGLEILSLFV
NMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWDYYLRQLQNKQFKRIRKSSFY
DYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFV
NKSLLFCDRNGKSFRYYLHDLQVDFLIEKNRNQLQDLHKKIVTQFQKHYQPHTLSPDQED
CMYWYNFLAYHMASASMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCA
VCENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDHGMLYLEWIN
KKNIKNLSRLVVRPHTDAVYHACFSEDGQRIASCGVDKTLQVFKAETGEKLLEIKAHEDE
VLCCAFSTDDRFIATCSVDKKVKIWNSMTGGLVHVYDEHSEQVNCCHFTNNSHYLLLATA
SSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDVKSANERK
SINVKQFFLNSEEPQEDMEVIVKCCSWSADGTRIMVAAKNKIFLFDIHTGGLLAEIHTGH
HSTIQYCDFSPQNHLAVVALSQCCVELWNMDSCLKVADCRGHLSWVHCVMFSPDGSSFLT
SSDDQTIRLWETKKVCKNSAIVLKQEIDVVFQENEVMVLAVDNIKRLQLINGKTGQIDYL
IEAQVSCCCLSPHLQYIAFGGEDGAVEILELLNNRIFQSRIGHKKTVRHIQFTDDGKTLI
SSSDDSSIQVWNWQSEEYVFLQAHQETVKDFKLLKNSKLLSWSFDGTVKIWSIITGRIEK
DFVCHQDTVLSCDISPDATKFSSTSADKTAKIWSFELLSPLHELRGHKGCVRCSVFSVDS
TLLATGDDNGEIRIWNVSNGELLHLCAPILVEEGAATHGGWVTDLCFSPDSKMLVSAGGY
LKAITSPGTPFHPSVSLHAANTYVTKSWNGCSRSHKKREHHAMLKKAGQIQQEEELPARE
LA
NT seq 3789 nt   +upstreamnt  +downstreamnt
atggatgcaaaagctcgaaactgtttgcttcaatatagagaagccttggaaaaggacatc
aaaacgtcctacatcatggatcgtatgattaatgacggagttttaacaatatcagaggag
gaaaaagtaaaaaatgagcccactcaacagcaacgagcagctctgctaattaaaacaata
cttaaaaaagataattattcctacatatcattctacaatgctctgatacatgaagggtat
aaagatcttgctgcccttctccatagtggcattcctgtcatctcttcttccaacggtggc
aaagattcagttggtggaataacttcacatgtgaagacagtcctgtgtgagggtggagtg
ccacagaggccagttgtttttgttaccaggaagaagctggtgaatgcaattcgtcagaac
ctattcaaactaagtgatgaaccaggatgggttgtcatatatggaatggcaggttgtggg
aagtctgttttagctgcagaagctgttcgagatcattttttcttagatggctgtttccca
gggggtgtacactgggtttcagttgggaaacaagacaaagctgggcttctgatgaaattg
cagaatctttgcacacggttggatcaggatgagaatttctctcagaggcctccactcaat
attgaagaagctaaagaccgtcttcgccttcttatgctgcgcaaacacccaaggtctctg
ttgatcttggatgatatttgggattcctggatattaaaagcttttgacaatcagtgtcag
attcttcttacaaccagagacaagagcgttacagattcagtaatgggtcctaaatatata
gtcgctgtggagagtgacttaggaaaagaaaaaggacttgaaattctgtccctctttgtt
aatatgaagaaagcagatttgccagagcaagctcatagtattataaaagaatgtaaaggt
tctcctctcgtagtgtctttaattggtgcacttttacgtgattttcctaaccgttgggat
tactacctcaggcaacttcagaataagcaatttaagagaataaggaaatcttcattttat
gattatgaggctctggatgaagccatgtctataagtgttgaaatgctcagagaggacatc
aaagattactacacagatctttccatccttcagaaggatgttaaggtgcctacaaaggtg
ttatgtattctctgggacatggaaactgaagaagttgaagatattctgcaggagtttgtt
aataagtctctcttattctgtgatcggaatggaaaatcatttcgttattatttacatgat
cttcaagtagatttccttatagagaagaatcgcaatcaacttcaggatctacataagaag
atagtcactcagttccagaaacattaccagccacatactctttcaccagatcaggaggac
tgcatgtactggtacaattttctggcctaccacatggctagtgccagtatgcacaaagaa
ctttgtgctttaatgttttccttggattggattaaagcaaaaactgaactcgtaggccct
gctcatctgattcatgaatttgtggaatacaggcatatattggatgaaaaggattgtgca
gtctgtgaaaatttccaggaatttttatctttaaatggacatcttcttggacgacagcca
tttcctaatattgtacaactgggtctctgtgaaccagaaacttcagaagtttatcagcaa
gctaagctgcaggccaagcaggaggtcgatcacggaatgctttacctggagtggataaac
aaaaaaaacatcaagaatctttcccgcttagttgtccgcccccatacagatgctgtttac
catgcttgcttttctgaggatggtcaaagaatagcttcttgtggagttgataaaacctta
caggtgttcaaagctgaaacaggagagaaactgctagaaatcaaggctcatgaagatgaa
gtgctttgttgtgcattctctacagatgacagatttatagcaacctgctcagtggataaa
aaagtgaagatttggaattctatgacagggggactagtacatgtctatgatgagcactca
gagcaagtcaactgctgccactttaccaacaacagtcattaccttctcttagccactgca
tcaagtgactgcttcctcaaactctgggatttgaatcaaaaagaatgtcgaaataccatg
tttggccatacaaattcagtcaatcactgcagattttcaccagatgataagcttttggct
agttgttcagctgatggaacattaaagctttgggatgtaaaatcagcaaatgagaggaaa
agcattaatgtgaagcagttcttcctaaattcagaggagcctcaagaggatatggaagtg
atagtgaaatgttgttcatggtctgctgatggcactaggataatggtggcagcaaaaaat
aaaatctttctatttgacattcatactggtggcttattggcagaaatccatacaggccat
cacagcaccatccagtactgtgacttctccccccaaaatcatttggcagtagtggctttg
tcccagtgctgtgtggagttgtggaacatggactcctgtttaaaagtggctgattgcaga
ggacatttaagttgggttcattgtgtgatgttttctcccgatggatcatcatttttgaca
tcttctgatgaccagacaatcaggctctgggagaccaaaaaagtatgtaagaactctgct
atagtgttaaagcaagaaatagatgttgtgtttcaagaaaatgaagtgatggttcttgca
gttgacaatataaaacgtctgcagctcattaatggaaaaacaggtcagattgattatctg
attgaagctcaggttagttgctgttgcctaagtccacatcttcagtacattgcatttgga
ggtgaagatggagccgttgagattttagaactcctaaacaacagaatcttccaatccagg
attgggcacaagaaaactgtgcggcacatccagttcacagatgatgggaagactcttatt
tcaagctctgatgattcttcaattcaggtatggaattggcagtcagaggaatatgtcttc
ctacaagcccatcaggaaactgtgaaagactttaagctcctgaaaaattcaaaactgctt
tcctggtcatttgatggaacagtaaagatatggagtattattactggaagaatagaaaaa
gactttgtctgtcaccaggatacagtactttcttgtgatatttctcctgatgctaccaag
ttttcatctacatctgcagataagactgcgaagatttggagttttgaacttctttcacct
cttcatgaattgaggggccacaagggctgtgtgcgctgctctgtcttctctgtggacagt
accctgttggcgactggagatgacaatggagaaatcaggatatggaatgtctcaaatggt
gagctgcttcatttgtgtgctccgattttggtagaagaaggagctgctacccatggaggc
tgggtgactgacctttgcttttctccggatagcaaaatgcttgtctctgctggaggatat
cttaaggcgatcaccagcccagggacaccgttccacccgtctgtttccctacatgctgcc
aacacctatgtcactaagtcttggaatggctgttcaagaagccacaaaaaacgggaacac
catgcaatgctaaagaaggctgggcagattcagcaggaagaggaactgccagcccgtgag
ctggcatga

  All links  
Ontology (1)   
   KEGG BRITE (1)   
Pathway (21)   
   KEGG PATHWAY (21)   
Genome (1)   
   KEGG GENOME (1)   
Gene (20)   
   KEGG ORTHOLOGY (1)   
   RefGene (14)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (55)   
   RefSeq(pep) (55)   
DNA sequence (100)   
   RefSeq(nuc) (100)   
Protein domain (20)   
   Pfam (20)   
All databases (218)   

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