KEGG   Canis lupus familiaris (dog): 484990
Entry
484990            CDS       T01007                                 
Symbol
INSR
Name
(RefSeq) insulin receptor isoform X3
  KO
K04527  insulin receptor [EC:2.7.10.1]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04010  MAPK signaling pathway
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04022  cGMP-PKG signaling pathway
cfa04066  HIF-1 signaling pathway
cfa04068  FoxO signaling pathway
cfa04072  Phospholipase D signaling pathway
cfa04150  mTOR signaling pathway
cfa04151  PI3K-Akt signaling pathway
cfa04152  AMPK signaling pathway
cfa04211  Longevity regulating pathway
cfa04213  Longevity regulating pathway - multiple species
cfa04520  Adherens junction
cfa04910  Insulin signaling pathway
cfa04913  Ovarian steroidogenesis
cfa04923  Regulation of lipolysis in adipocytes
cfa04930  Type II diabetes mellitus
cfa04931  Insulin resistance
cfa04932  Non-alcoholic fatty liver disease
cfa04960  Aldosterone-regulated sodium reabsorption
cfa05010  Alzheimer disease
cfa05415  Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    484990 (INSR)
   04014 Ras signaling pathway
    484990 (INSR)
   04015 Rap1 signaling pathway
    484990 (INSR)
   04066 HIF-1 signaling pathway
    484990 (INSR)
   04068 FoxO signaling pathway
    484990 (INSR)
   04072 Phospholipase D signaling pathway
    484990 (INSR)
   04022 cGMP-PKG signaling pathway
    484990 (INSR)
   04151 PI3K-Akt signaling pathway
    484990 (INSR)
   04152 AMPK signaling pathway
    484990 (INSR)
   04150 mTOR signaling pathway
    484990 (INSR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04520 Adherens junction
    484990 (INSR)
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    484990 (INSR)
   04923 Regulation of lipolysis in adipocytes
    484990 (INSR)
   04913 Ovarian steroidogenesis
    484990 (INSR)
  09155 Excretory system
   04960 Aldosterone-regulated sodium reabsorption
    484990 (INSR)
  09149 Aging
   04211 Longevity regulating pathway
    484990 (INSR)
   04213 Longevity regulating pathway - multiple species
    484990 (INSR)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    484990 (INSR)
  09166 Cardiovascular disease
   05415 Diabetic cardiomyopathy
    484990 (INSR)
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    484990 (INSR)
   04932 Non-alcoholic fatty liver disease
    484990 (INSR)
   04931 Insulin resistance
    484990 (INSR)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:cfa01001]
    484990 (INSR)
  09183 Protein families: signaling and cellular processes
   04090 CD molecules [BR:cfa04090]
    484990 (INSR)
Enzymes [BR:cfa01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.1  receptor protein-tyrosine kinase
     484990 (INSR)
Protein kinases [BR:cfa01001]
 Receptor tyrosine kinases (RTK)
  INSR family [OT]
   484990 (INSR)
CD molecules [BR:cfa04090]
 Proteins
  484990 (INSR)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase Recep_L_domain Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476
Other DBs
NCBI-GeneID: 484990
NCBI-ProteinID: XP_022262798
Ensembl: ENSCAFG00000018170
VGNC: 42043
Position
20:complement(51822227..51957301)
AA seq 1186 aa
MRCFPGGAKGTPNKVEPCPRGDFCPTICKSHGCTAEGLCCHSECLGNCSEPDDPTKCVAC
RNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHNKCKNSRRQGCHQYVIHNNKCIPEC
PSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGCTVVNGSLIINIRGGN
NLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNL
RQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASC
ENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNS
WTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYV
QTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELYELDYCL
KGLKLPSRTWSPPFEAEGSQKHNQSEYEESAGECCSCPKTDSQILKELEESSFRKTFEDY
LHNVVFVPRKSSSSPGAEDTRPSRKRRALSDAGNVTAAIPTVPGFPNTSTSTPTSPEEHK
PFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVSARTMPEAKADDIVGP
VTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRLRGL
PPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIY
LFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGSFGM
VYEGNARDIVKGEPETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKG
QPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFV
HRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTS
SDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFN
PKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMESVPLDRASHSQ
REEAGGRDAGSSLGLKRSYEEHIPYTHMNGGKKNGRILTLPRSNPS
NT seq 3561 nt   +upstreamnt  +downstreamnt
atgaggtgttttcctgggggtgcaaaggggacacccaacaaggtggagccgtgtccccgt
ggagacttttgtccgaccatctgcaagtcgcatggctgcaccgccgagggcctctgctgc
cacagcgagtgtttaggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgt
cgcaacttctacctggatggcaggtgcgtggagacctgcccacccccgtactaccacttc
caagactggcgctgcgtgaacttcagcttctgccaggacctgcacaacaaatgcaagaac
tcccggagacagggctgccaccagtacgtcatccacaataacaagtgcatccccgagtgc
ccctctggctacacgatgaattccagcaacctgatgtgcactccgtgcctgggcccctgt
cccaaggtctgccacattctggaaggcgagaagaccatcgactcagtgacgtctgcccag
gagcttcgaggctgcactgttgtcaacggaagtctaatcatcaacattcgagggggcaac
aacctggcggccgagctggaggccaacctcggactcattgaagagatttccgggtacctg
aaaatccggagatcctatgctcttgtgtctctttcctttttccggaagttgcggctgatt
cgaggggagaccttggagatcgggaactactctttctatgccttggacaaccagaaccta
aggcagctatgggactggagcaaacacaacctcaccatcactcaggggaaactcttcttc
cactataatcccaaactctgcttgtctgagatccacaagatggaggaagtctcaggaacc
aaggggcgccaggagaggaacgacattgccctgaagaccaacggggaccaggcgtcttgt
gaaaacgaactacttaaattttcttacattcggacgtcttatgacaagatcttgctgaaa
tgggagccctactggccccctgacttccgagacctcctggggttcatgctcttctacaaa
gaggccccttatcagaatgtgaccgagtttgatgggcaggacgcgtgtggctccaacagc
tggacggtggtggacattgacccacctctgcggtccaacgaccccaaatcgcagaaccac
ccggggtggctgatgcggggtctcaagccctggacccaatatgccatctttgtcaagacc
ttggtcaccttttctgatgaacgccgcacgtatggagccaagagtgacatcatctatgtg
cagacagatgccactaatccttccgtccccctggatccaatctcggtttcgaattcctcg
tcccagattattctgaagtggaagcctccctctgaccccaatggcaatatcacgcactac
ctggttttctgggagaggcaggccgaagacagtgagctctatgagttggattattgcctc
aaagggttgaagctgccctcccggacctggtctccgccgttcgaggccgagggctcccag
aagcacaaccagagtgaatacgaggagtctgccggcgaatgctgctcctgccccaaaacg
gactctcagatcctcaaggagctagaggagtcctcttttaggaagacgtttgaggattac
ctgcacaacgtggtgtttgtccccagaaaatcctcttcgagccctggtgctgaggacact
aggccatcgaggaaacgcagggcgctcagtgatgctggcaacgtgacagcagctataccc
acagttcccggtttccccaacacctcgaccagcacgcccacgagcccggaggagcacaag
cccttcgagaaagtggtgaacaaagaatctctggtcatctccggtctgcgccacttcact
ggctaccgcatcgagctgcaggcttgcaaccaagactcccccgaggagaggtgcagcgtg
gcggcctatgtcagcgccaggaccatgcccgaagccaaggcagacgacatcgttggcccc
gtgacccacgaaatcttcgagaacaatgtcgttcacttgatgtggcaggagccaaaggaa
cccaatggtctgatcgtgctttatgaagtgagttaccgacggtatggcgatgaggagctt
cacctgtgtgtctcccggaggcattttgctctggagcgtggctgcaggctacgcgggctg
cctccggggaattacagcgtgcgagtccgggccacctccctggcgggtaatggctcctgg
acagaagccacctatttctacgtgacagactatttagatgtcccatcgaatattgcaaaa
attatcatcggccccctcatctttgtctttctcttcagtgttgtgattggaagtatttac
ctgttcctgagaaagaggcagccggatgggccactgggaccgctgtatgcttcttcaaac
cctgagtacctcagtgccagtgatgtgtttccatgttctgtgtatgtgccggacgagtgg
gaggtgccgcgggagaagatcaccctcctgcgcgagctggggcaaggctccttcggcatg
gtgtacgagggcaacgccagggacatcgtcaagggtgagcccgagacccgcgtggccgtc
aagaccgtcaacgagtccgccagcctgcgagagaggatcgagtttctcaatgaggcatca
gtcatgaagggcttcacctgtcaccacgtggtccgcctcctgggggtggtgtccaaaggc
caaccgacgctggtggtgatggagctgatggctcatggagacctgaagagctacctccgc
tccctgcggccggaggctgagaataaccccggccgccctccgcctaccctgcaagagatg
attcagatggcggcggagatcgccgacgggatggcctacctgaacgccaagaagtttgtg
caccgggatctagcagcccgaaactgcatggtcgcccacgatttcactgtcaaaattgga
gactttgggatgaccagagacatctatgagacggattactatcggaaaggaggcaagggt
ctgctccccgtgcggtggatggcaccggagtccctgaaggacggggtctttaccacttct
tctgacatgtggtcctttggcgtggtcctttgggaaatcaccagcttggcagagcagcct
taccaaggcctgtctaatgaacaggtgttgaaatttgtcatggacggagggtatctggat
caacccgacaattgtccagagagagtcactgacctgatgcgcatgtgctggcagttcaat
cccaagatgcggcccaccttcctggagattgtcgacctgctcaaggatgatctgcacccc
agctttccagaagtttccttcttccacagcgaggagaacaaggcacccgagagcgaggag
ttggagatggagtttgaggacatggagagtgtccctctggatcgggcctcacactctcag
agggaggaggccgggggccgggatgcagggtcctcgctgggcctaaagcggagctacgag
gagcacatcccctacactcacatgaacgggggcaagaaaaatggacggattctgactctg
ccaaggtcgaatccttcctaa

  All links  
Ontology (4)   
   KEGG BRITE (4)   
Pathway (22)   
   KEGG PATHWAY (22)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (17)   
   RefSeq(pep) (17)   
DNA sequence (17)   
   RefSeq(nuc) (17)   
Protein domain (9)   
   Pfam (9)   
All databases (93)   

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