KEGG   Canis lupus familiaris (dog): 486808
Entry
486808            CDS       T01007                                 
Symbol
PLCE1
Name
(RefSeq) 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
  KO
K05860  phosphatidylinositol phospholipase C, epsilon [EC:3.1.4.11]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa00562  Inositol phosphate metabolism
cfa01100  Metabolic pathways
cfa04014  Ras signaling pathway
cfa04015  Rap1 signaling pathway
cfa04020  Calcium signaling pathway
cfa04024  cAMP signaling pathway
cfa04070  Phosphatidylinositol signaling system
cfa04919  Thyroid hormone signaling pathway
cfa04933  AGE-RAGE signaling pathway in diabetic complications
cfa05205  Proteoglycans in cancer
Module
cfa_M00130  Inositol phosphate metabolism, PI=> PIP2 => Ins(1,4,5)P3 => Ins(1,3,4,5)P4
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00562 Inositol phosphate metabolism
    486808 (PLCE1)
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    486808 (PLCE1)
   04015 Rap1 signaling pathway
    486808 (PLCE1)
   04020 Calcium signaling pathway
    486808 (PLCE1)
   04070 Phosphatidylinositol signaling system
    486808 (PLCE1)
   04024 cAMP signaling pathway
    486808 (PLCE1)
 09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    486808 (PLCE1)
 09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    486808 (PLCE1)
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    486808 (PLCE1)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    486808 (PLCE1)
Enzymes [BR:cfa01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.11  phosphoinositide phospholipase C
     486808 (PLCE1)
Membrane trafficking [BR:cfa04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Phospholipases
    486808 (PLCE1)
 Endocytosis
  Macropinocytosis
   Phospholipase C
    486808 (PLCE1)
SSDB
Motif
Pfam: PI-PLC-X PI-PLC-Y RasGEF RA C2 EF-hand_like GDPD
Other DBs
NCBI-GeneID: 486808
NCBI-ProteinID: NP_001130037
Ensembl: ENSCAFG00000007985
VGNC: 44650
Position
28:8387216..8659466
AA seq 2309 aa
MTSEGMAASVLTPVTQRKVTFAPSAVDESSEKVSDISVPKAHSVKQSEQTSTIPWMNKLK
EESSGSNLPKILSIAREKIASDENSNEECWTESTPVSVKNLNINHNNILTNRQCVLPQSQ
SYDTCNSVMEEDPCLETGISSSLERKVFPGIQLEVNRPPMDFRPPGLMDFSTLGSQSAIV
DTGQAHPDSNKAAFQIFNYKVDRRMSDTFCTLSGDLILDDCGNCVPLSSGFGGEQKKNYV
AYTCKLMELAENCDNENGQLQCDDYDALDDKYLCFEDSCQRDSVVCSSDSFRREDLTNSP
PAKTFLSHFEDFPDNGEDVEDFLKNKKERSTLLVRRFCKNDREVKKSVYTGTRAIMRTLP
SGHIGLEAYSYIDQKRSGPLLPRGRVLEQLPVVAIRQDGSQCLSEAQWYRIYNAVRREEE
IENTIGSLLHYFTKLPASKTAHERISVGPCLKQCVRDTICEYRATLQRTSISQYITGSLL
EATTSLGARSGLLSTFGGSTGRMMLKERQPGTSMANSSALPSSSAGISKELIDLQPLIQF
PEEVASILMEQEQNIYRRVLPVDYLYFLTRDLGTPECQTPLPCLKASISASILSSQNGEH
NALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNAVMEFLAGL
RSRKVLKMWQFMDQSDLETMRSLKDAMAQHESSCEYRKVITRALHIPGCKVVPFCGVFLK
ELCEVLDGASGLMKLCPRYNSQEETLEFVADYSGQDNFLQRVGHNGLKNSEKESTVNSIF
QIIRSCSRSLEAEEEDSPSEGNSSRKNSLRDKARWQFIIGDLLDSENDIFEQSKEWDSPS
SEEPQKAFDHGTELIPWYVLSIRADVHQFLLQGATVLRYDQDTHLSARCFLQLQPDNSTL
TWIKPTAASPASARAKLGVLSNTSEPGKFPSPGSAGLSGLAEGVLDLFSAKAVYMGHPSI
DIHTVCVQNKLGSMFLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTRAVRK
MRKFPDQRQQWLRKQYVSLYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGTSAKSAEKP
SVQRNNTLGISTTKKKKKILIRGESGEAADDEMATRKAKMHRECRSRSGSDPQDMNEQEE
SEANAIMSPPNTLPSRRAHSLTTAGSPNLSAGTSSPIRPVSSPVLSSSNKSPSSAWSSSS
WHGRIKGGMKGFQSFMVSDSNMSFVEFVELFKSFSVRSRKDLKDLFDIYAVPCNRAGSES
APLYTNLTIDENTSDLQPDLDLLTRNVSDLGLFIKSKQQLSDNQRQISDAIAAASIVTNG
TGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPSISMCHQGLLSFEGFA
RFLMDKDNFASKNDESQENIKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQ
GCRSVELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSL
PQQRKMAEIFKTVFGEKLVAKFLFESDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDI
LKQKAHQLASMQAQAYNGGNVNPPPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSC
NDKLQFEYNEEIPKRIKKADNSAFNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIY
CQAVKFPGLSTLNASGSNRGKERKSRKSIFGNNPGRMSPGETASFNKASGKSSCEGMRQA
WEESSSPLNPTTSLSAIIRTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAA
TRIDSSNPNPLLFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCP
MYQKFSPLERDLDNMEPAVYSLTIVSGQNVCPSSSTGSPCIEVDVLGMPLDSCHFRTKPI
HRNTLNPMWNEQFLFRVHFEDLIFLRFAVVENNSSAITAQRIIPLKALKRGYRHLQLRNL
HNEVLEISSLFINSRRMEENSSSSATPASLMFNTEERKCLQTHRVTVHGVPGPEPFTVFS
ISGGTKAKQLLQQILTTEQDTKPIVTDYFLMEEKYFISKEKNECRKQPFQRVIGPEEEIM
QILSSWFPEEGYVGRIVLKTQQENLEERSIVQDEKEVILSSEEESFFVQVHDVSPEQPRT
VIKAPRVSTAQDVIQQTLCKAKYSYSILSNPNPSDYVLLEEVVKDATKKSSTPKSSQRVL
LDQECVFQAQSKWKGAGKFILRLKEQVQASREDKRKGISFASEFKKFTKSTKQPRGLTSS
QVLASESVQNKEEKPTGSLSSSDTTDSRQ
NT seq 6930 nt   +upstreamnt  +downstreamnt
atgacttctgaaggaatggcagcttctgttctcacacctgtgactcaaagaaaagtgaca
tttgctccatcggctgtagatgaaagtagtgaaaaggtctcagacatcagtgttccaaag
gcacatagtgtcaagcagagtgagcagacttctaccatcccgtggatgaacaagcttaaa
gaagaatcttctggaagcaacttgcccaaaattctctccatagcaagggagaaaatagca
agtgatgagaacagcaatgaagagtgctggacggaaagcacaccagtttctgtgaaaaac
cttaacattaaccataacaacatcctgacaaaccgccagtgcgtccttcctcagagccag
tcttatgacacgtgcaattctgtcatggaggaagacccatgtttagaaactggaatctca
tcctcactggaaagaaaggtattccctggaattcaactggaagtcaacagacctcccatg
gactttaggcctccaggcctaatggactttagtaccttaggaagtcagtcagccattgta
gatactggccaggcgcaccctgacagcaacaaagcagcatttcaaatctttaattataaa
gttgacagaaggatgtctgacactttctgtaccctgtcaggtgacttgatattggatgac
tgtggaaactgtgtgccactgtcatctggttttggcggggagcaaaagaaaaattacgtg
gcatatacctgtaaactcatggaattggctgaaaactgtgataatgagaatggacagctg
cagtgtgatgattatgatgccttggatgacaaatacttgtgctttgaagattcttgccaa
agggacagtgtggtatgttcaagtgacagctttcgcagggaggacctaactaacagtcca
cctgccaagacctttctgagccattttgaagacttccctgataatggtgaagatgtagaa
gattttttaaaaaacaaaaaggagagatccactttgttagtgaggagattttgtaaaaat
gacagagaagtaaagaaatctgtgtatactgggacaagggcaatcatgagaactctgcct
tctggtcacattgggctggaagcttacagttacatcgatcagaagagaagtggtccctta
ttaccccgtgggagagttctggaacagctgccagtggtggcaattaggcaagatgggagc
cagtgcctgtcagaagcccagtggtatcggatctacaatgcagtgagaagggaagaagaa
atagaaaataccattggatctcttctccattactttaccaagctcccagcctccaagaca
gcccatgaaaggattagtgttggtccatgcctaaagcagtgtgtccgagacaccatatgt
gagtatcgtgccaccctccagaggacgtccatatctcagtacatcacgggttcgctccta
gaagcaaccacatctttaggagcgagaagtggcctactcagtacttttggaggatccact
ggacgaatgatgctaaaagaacgccagccaggcacctccatggccaattccagtgccctc
ccttcaagttccgctggaatcagcaaggagctgattgacctgcagcctctcattcagttc
ccagaggaagtcgccagcatcctgatggagcaggaacagaacatttaccgaagggtctta
ccagttgactatctttacttcttgacccgggacttgggcactccagaatgccagacaccc
ctgccctgcctcaaagcatccatctcagcttcaattcttagctcccagaacggagagcac
aatgccctggaagatcttgtgatgagatttaatgaggtgagctcctgggtgacatggctg
atcctcacggcgggctccatggaggagaagcgagaagtcttctcctatttggtgcatgtg
gccaaatgctgctggaacatgggcaactacaatgctgtcatggagttcttggctggtctc
aggtcaagaaaagttttaaaaatgtggcagtttatggaccaatctgacctcgagaccatg
aggagcctgaaggacgccatggctcagcatgaatcttcctgcgaatatcggaaggtgata
acgagggctctgcacatacctggctgtaaagtggttccattctgtggagtgtttctgaag
gagctctgtgaagtactggacggagcctctggcctcatgaagctttgcccgaggtacaat
tcccaagaagaaactctagagtttgtagcagattacagtggacaagataatttcttacaa
cgagtggggcataatggcttaaagaattcagagaaggagtccactgtcaacagcatcttt
caaatcattaggagctgcagccgaagtctggaggctgaggaagaggacagccccagtgaa
gggaacagctctaggaaaaattctttaagggacaaagcccgatggcaatttataatcgga
gatttgttggattccgaaaatgacatctttgagcaatccaaagaatgggactctcccagc
tcagaagagcctcagaaagcctttgaccatgggacagagctgatcccttggtacgtgctg
tccatccgagcagatgtgcaccagttcctgctacagggcgccaccgtcctccgctacgac
caggacacgcacctctctgcccgctgcttcctccagcttcagcctgacaatagcaccttg
acatggataaagcccacagctgcctccccggccagtgctagagcaaaactcggtgtgctg
agcaacacgtctgagcctggcaagttcccgtcaccaggcagtgccggactaagcggcctg
gccgagggggtcctggatctgttttcagcaaaggctgtgtacatgggacaccctagcatt
gatatccacactgtgtgtgtccagaacaaactcggtagcatgtttctctcagagactggc
gtgaccctgctctacgggctccagaccacagacaatagattattgcactttgtggcaccc
aaacacactgctaagatgctcttcagtggattgctagaactcacgagggccgtgaggaag
atgagaaagttccctgaccagaggcagcagtggctgcggaaacagtatgttagcctctat
caggaggacggacggtatgagggcccaactttggctcatgctgtggagttgtttggtggc
cggcgatggagtacacgcaatcccagccctgggacatctgcaaagagtgctgagaagccc
agtgtgcagagaaacaacaccttgggcataagcaccaccaagaaaaagaagaaaatcctt
ataaggggtgagagtggagaggcagccgacgatgagatggccacccggaaggccaaaatg
cacagggagtgtcgcagccggagtggttctgacccacaagacatgaatgagcaagaagaa
tctgaggcaaatgccatcatgagccctcctaacactctgccttccagaagagcccactct
ttgactacagctgggtcccctaatttgtctgccgggacatcatctcccatcaggccagtg
tcctcccctgtgctgtcttcttcaaacaagagcccgtccagtgcttggagcagcagcagc
tggcatggaaggatcaaaggaggaatgaagggttttcagagcttcatggtttcagacagt
aacatgagttttgttgaatttgttgagctgttcaaatcattcagtgtgaggagccgcaag
gacctgaaggatctctttgacatctacgctgtgccctgcaatcgggccggctctgagtcg
gccccgctctacaccaacctaacaatagacgaaaacaccagcgatcttcagcctgaccta
gatttattgaccagaaacgtctcggatttggggttgttcattaagagtaaacagcagctg
tcagacaaccagaggcagatttctgatgccattgctgctgcaagtatcgtgacgaatggc
actgggatcgagagcacatctttgggcatctttggggttggcatactccagctcaatgac
ttcctagtcaactgccagggagaacactgcacttacgatgaaatcctcagcatcatccag
aagttcgagcctagcattagtatgtgtcatcagggcctactgtcctttgaaggatttgca
aggtttctgatggataaagataattttgcctccaaaaatgatgagtcacaggagaacatt
aaagatttgcagctgcctctctcctactattacattgagtcttcacacaatacctacctc
acaggccaccagctcaaaggagagtcatcggtagaactctatagccaggtcctcctgcaa
ggctgtagaagtgtagagttggactgctgggatggagatgacgggatgcccatcatctat
cacggacacacactaacaaccaagatccccttcaaggaggtggttgaagccatcgaccgc
agtgccttcatcaactctgacctgcccatcatcatatcgattgagaaccactgctcgttg
cctcagcaacgaaaaatggcagaaattttcaagactgtgtttggagaaaaactggtggct
aaattcctgtttgagagcgatttctcagatgatccaatgcttccctcacctgaccaactt
aggaggaaagtgcttcttaaaaataagaagctaaaagcccaccagacaccagtggatatc
ttaaagcaaaaggctcatcagttagcatccatgcaagctcaggcttataatgggggaaat
gtcaaccctccacctgctaataacgaggaagaggaagatgaagaggacgaatatgattat
gactatgaatccctgtctgatgacaacattctagaagacagacctgaaaataaatcatgt
aatgacaagcttcagtttgagtataacgaagaaatccccaagaggataaagaaagcagat
aattctgctttcaacaaaggaaaggtttatgacatggaactgggagaagaattttatctt
cctcagaataaaaaggaaagcagacagattgcaccagagctttctgaccttgtcatctac
tgccaagcggtaaagtttccggggctgtcaactctaaatgcatctggctctaacagagga
aaagagaggaaaagcaggaagtccatttttggcaacaatccgggcagaatgagccctggg
gagacagcatcgtttaacaaagcatctggaaaaagttcctgtgaaggaatgcgacaggcg
tgggaggaatcttcttcccccctcaacccaaccacatccctcagcgctatcattagaact
cccaaatgttaccatatctcatcgctgaatgaaaatgccgccaaacgtctgtgtcgcagg
tattctcagaaactgatccagcacactgcctgtcagctgctgaggacttacccggctgcc
acacgcatcgactcctccaaccccaatcctctcttgttctggctccatgggatacagctc
gtggcactcaactaccagacagatgatctccctttacatttaaatgctgccatgtttgag
gccaacggtggctgtggttatgttttgaaaccccccgttctgtgggacaagaactgtccc
atgtaccagaagttttcacccttggaaagagacctggacaacatggagcctgccgtctat
tccttaactattgtctctggtcaaaacgtgtgcccaagtagcagcacgggaagcccatgt
atcgaagtggacgtgctgggcatgcccctggacagttgccacttccgcacaaaacccatc
caccggaacactttgaaccccatgtggaatgaacagtttctcttccgggttcactttgaa
gatctcatattcctgcgttttgcagttgtggaaaacaatagctcagccataaccgctcag
agaatcatccccctcaaggctttaaaacgaggatatcgacatcttcagctgcgaaacctc
cacaatgaagtcttggaaatctctagtttattcataaacagcagaaggatggaagaaaat
tcctccagcagtgccacgccagcctctttgatgtttaatacagaagaaagaaaatgtttg
cagactcacagagtcacagtgcatggggtcccaggtccagagccctttactgttttctcc
ataagtggaggcacgaaggcaaagcagcttctccaacagattctaactactgaacaagac
accaaacctattgtcacagactattttttgatggaagaaaaatattttatatctaaagaa
aagaatgaatgcaggaaacaaccatttcagagagtcatcggtccagaagaagagatcatg
cagattttaagcagctggtttccagaggaaggatatgttggcaggattgtcttaaaaacc
cagcaggaaaacctagaagagagaagcattgttcaagatgagaaagaggtgatcttgagc
tcggaggaggagagcttctttgtccaagtgcatgacgtttctccagagcaacctcggacg
gtcatcaaagcgccccgtgtcagcaccgctcaggatgtcattcaacagaccttatgcaaa
gccaaatattcctatagcatcctgagtaaccccaacccgagtgactatgtgcttctggaa
gaggtggtgaaagatgctaccaagaagtcctccaccccaaagtcctcccagcgggtcctt
ttggaccaagagtgtgtgtttcaagcccagagcaagtggaaaggtgctggaaaattcatc
ctcaggctaaaggagcaggtgcaggcatcccgagaagataaaagaaaaggcatttctttc
gcaagtgaattcaagaagttcaccaaatcaactaaacagccccgaggactcacatcttct
caggtcttggcctcagaaagtgtccaaaacaaggaggagaagcccacgggcagcttgtcc
tccagtgacaccacagactcccgacaataa

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (11)   
   KEGG PATHWAY (10)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (4)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (7)   
   RefSeq(pep) (7)   
DNA sequence (7)   
   RefSeq(nuc) (7)   
Protein domain (7)   
   Pfam (7)   
All databases (73)   

Download RDF
DBGET integrated database retrieval system