KEGG   Canis lupus familiaris (dog): 492302
Entry
492302            CDS       T01007                                 
Symbol
CFTR
Name
(RefSeq) cystic fibrosis transmembrane conductance regulator
  KO
K05031  cystic fibrosis transmembrane conductance regulator [EC:5.6.1.6]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa02010  ABC transporters
cfa04024  cAMP signaling pathway
cfa04152  AMPK signaling pathway
cfa04530  Tight junction
cfa04971  Gastric acid secretion
cfa04972  Pancreatic secretion
cfa04976  Bile secretion
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09130 Environmental Information Processing
  09131 Membrane transport
   02010 ABC transporters
    492302 (CFTR)
  09132 Signal transduction
   04024 cAMP signaling pathway
    492302 (CFTR)
   04152 AMPK signaling pathway
    492302 (CFTR)
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    492302 (CFTR)
 09150 Organismal Systems
  09154 Digestive system
   04971 Gastric acid secretion
    492302 (CFTR)
   04972 Pancreatic secretion
    492302 (CFTR)
   04976 Bile secretion
    492302 (CFTR)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02000 Transporters [BR:cfa02000]
    492302 (CFTR)
Enzymes [BR:cfa01000]
 5. Isomerases
  5.6  Isomerases altering macromolecular conformation
   5.6.1  Enzymes altering polypeptide conformation or assembly
    5.6.1.6  channel-conductance-controlling ATPase
     492302 (CFTR)
Transporters [BR:cfa02000]
 ABC transporters, eukaryotic type
  ABCC (CFTR/MRP) subfamily
   ABCC7 subgroup
    492302 (CFTR)
SSDB
Motif
Pfam: CFTR_R ABC_membrane ABC_tran AAA_21 SMC_N AAA_29 AAA_16 DUF87 T2SSE AAA_23 RsgA_GTPase MMR_HSR1 ATP-synt_ab nSTAND3 MeaB Zeta_toxin NTPase_1 AAA_30 Intein_splicing
Other DBs
NCBI-GeneID: 492302
NCBI-ProteinID: NP_001007144
Ensembl: ENSCAFG00000003429
VGNC: 39180
UniProt: Q5U820
Position
14:55685755..55848173
AA seq 1483 aa
MQRSPLEKASVLSKLFFSWTRPILIKGYRQRLELSDIYQVPSTDSADHLSEKLEREWDRE
LASKKNPKLINALRRCFFWRFAFYGILLYLGEVTKAVQPLLLGRIIASYDPDNKQERSIA
IYLAIGLCLLFIMRPLLLHPAIFGLHHIGMQIRIAMFSLIYKKTLKLSSRVLDKISIGQL
VSLLSNNLNKFDEGLALAHFVWIAPLQVTLLMGLLWDLLQASAFCGLAFLIVLALVQAGL
GRMIMKYRDQRAGKINERLVITSEVIENIQSVKAYCWEEAMEKIIENIRQTELKLTRKAA
HVRYFNSSAFFFSGFFVVSLSVLPYALIKTIILRKIFTTISFCIVLRMAVTRQFPWAVQT
WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVMMENVTAFWEEGFGELLEKAKENSNDRK
ISNGDNSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMMIMGELEPSEG
KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV
LGEGGVTLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR
ILVTSKMEHLKKADKVLILHEGSCYFYGTFSELQSLRPDFSSKLMGYDSFDQFSPERRNS
IITETLRRFSLEGDAAVPWNETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLP
MNGIEGESEVPVERRLSLFPDCEQGEAILPRSNMINTGPTLRRQRRQSVLNLMTRSSVNQ
GQSIHRRTTASTRKMSLAPQANLTEMDIYSRRLSQDSGLEISEEINEEDLKECFFDDVES
IPPVTTWNTYLRYITVHKNLIFVLIWCLVIFLAEVAVSLVVLWILRNLSSQDKGNSTQSV
NSSYAVIFTSTSAYYIFYIYVGVADTLLALGLFRGLPLVHTLITASKILHHKMLHSVLQA
PMSTLNTLKAGGILNRFPKDIAILDDLLPLTIFDFIQLLLIVIGAVAVVSVLQPYIFLAT
VPVIAAFIILRAYFLHTSQQLKQLESEGRSPIFTHLLTSLKGLWTLRAFGRQPYFETLFH
KALNLHTANWFLYLSTLRWFQMRMEIIFVIFFIAVTFISILTTGEGEGTVGIILTLAMNI
MGTLQWAVNPSIEVDSLMRSVSRVFKFIDMPTEESKPPTKSFKPSKDAQLSKVTITENRH
VREDDIWPSGGQMTVKDLTAKYIDGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAL
LRLVNTEGEIQIDGVSWDSIPLQEWRRAFGVIPQKVFIFSGTFRKNLDPYGQWNDQEIWK
VADEVGLRSVIEQFPGKLDFVLVDGGYVLSHGHKQLMCLARSVLRKAKILLLDEPSAHLD
PITYQIIRRTLKQAFADCTVILSEHRIEAMLECQRFLVIEDSRLRQFESIQRLLSERSAF
RQAIGPPERPGLLPHRLSSRQRSPSRIAALKEETEDEVQDTRL
NT seq 4452 nt   +upstreamnt  +downstreamnt
atgcagaggtcgcccctggaaaaggccagcgtcctctccaaacttttcttcagctggacc
agaccaattttgataaaaggctatagacaacgcctggaattatcagacatataccaagtc
ccttctactgattctgctgatcatctgtctgaaaaattggaaagagaatgggacagagag
ctggcatcaaagaagaaccccaaacttattaatgcccttcggcgatgctttttctggaga
tttgcgttctatggaatcttattatatttaggggaagtcaccaaagcagtccagcctctc
ttacttggaagaatcatagcttcctatgatccagataacaagcaggaacgctccattgca
atctacctagccattggcttatgccttctctttatcatgaggccgctgctcctgcaccca
gccatttttggccttcatcacattggaatgcagatcagaatagctatgtttagtttgatt
tataagaagactttaaagctgtcaagccgtgttctggataaaataagtattggacaactt
gttagtctcctttccaacaacctgaacaaattcgatgaaggacttgcactggcgcatttc
gtgtggattgctcctctacaagtgacgctcctgatggggctgctctgggatttgttacaa
gcctctgccttctgtggtcttgctttcctcatagtcctcgcccttgtccaagctggtttg
ggaagaatgataatgaagtacagagatcagagagctggaaagatcaatgaaagactcgtg
atcacctcagaagtgattgaaaatatccaatctgttaaggcatactgctgggaggaagca
atggaaaagataattgaaaacataagacaaacagagctgaaactgacccggaaggcagcc
catgtgagatacttcaatagctcagccttcttcttctcagggttctttgtggtgtcttta
tctgtgcttccctatgcactgatcaaaacaatcatccttcgcaaaatattcacaaccatc
tcattctgcatcgttttgcgcatggcagtcactcggcaatttccctgggctgtacaaaca
tggtatgactctcttggagcaataaacaaaatacaggatttcttacaaaagcaagagtat
aagacgttggaatataacttaacaactacggaagtaatgatggagaatgtaacagccttc
tgggaggagggatttggggaattacttgagaaagcaaaagaaaacagtaatgacagaaaa
atttccaatggggacaacagcctcttcttcagcaacttctcacttcttggtactcctgtc
ctaaaagacatcaatttcaagatagaaagaggacagttgttggcggttgctggatctact
ggagcaggcaagacttcactcctaatgatgattatgggagaactggagccttcagagggt
aaaattaagcacagtggaagaatttcattctgctctcagttttcttggattatgcctggc
accattaaagaaaacatcatctttggtgtttcctatgatgagtatagatataggagtgtc
atcaaagcatgccaactagaggaggacatttccaagtttgcagagaaggacaacatcgtt
cttggagaaggtggcgtcacgctgagcggagggcaaagagcaagaatttccctagcaaga
gcagtatataaagatgctgatttatatctcttagactctccttttggatacctggatgtt
ttaacagaaaaagaaatatttgaaagctgtgtctgtaaattgatggctaacaaaactagg
atcttggtcacttctaaaatggaacatttaaagaaagctgacaaagtcttaattttacat
gaaggtagctgctatttttatgggacattttctgaattacaaagtctccggcccgacttc
agctcgaagctcatgggctatgattcttttgaccagttcagtccagaaagaagaaactcc
atcatcactgagactttacggcgtttctccttagaaggagatgcggccgtgccctggaat
gaaacaaaaaagcaatcttttaaacagactggagagtttggtgaaaaaaggaagaactct
attcttaatccaatcaactccataagaaaattttcaattgtacaaaagaccccgttaccc
atgaatggcatcgaaggagagtctgaggtgccagtagagcgaaggctgtccttatttccc
gactgtgagcaaggagaggccatcctgcctcggagcaacatgatcaacactggccccacg
ctccggagacaacgaagacagtctgttctgaacctgatgacgcgctcctccgtgaaccaa
ggtcagagcattcaccgaaggacaacagcatccacgcgaaaaatgtcactggcccctcag
gcaaatctaactgaaatggatatatattccagacggttatctcaagacagtggcttggaa
ataagtgaagaaattaatgaagaggatttaaaggagtgcttttttgatgatgtcgagagc
ataccaccagtgactacatggaacacataccttcgatatattactgtccacaagaactta
atttttgtgctaatttggtgcttagttatttttctggctgaggtggctgtttcattggtt
gtattgtggatacttagaaacttgtcttctcaagacaaagggaatagcactcagagcgta
aacagcagttatgcagtgatcttcaccagtaccagcgcatattatattttctacatttat
gtgggagtagctgatactttgcttgctctgggactcttcagaggtttaccactggtgcat
actctaatcacagcgtcgaaaattttacaccacaaaatgttacattctgttcttcaggca
cctatgtcaaccctcaacacactgaaagcaggtgggattcttaatagattccccaaagat
atagcgattttggatgatcttctgccccttaccatatttgacttcatccagttgttatta
attgtgatcggagctgtggcggtggtgtcagttttacagccctacatcttcctagcgaca
gtgccagtgatagcggcctttattatcctgcgggcctacttcctccacacctcacagcaa
ctcaagcaactggaatctgaaggcaggagtccaattttcactcatcttcttacaagttta
aaaggactgtggacacttcgggcctttggacgccagccttactttgagactttgtttcac
aaagctctgaacttacatactgccaactggttcttgtacctgtcaacgctgcgctggttc
caaatgagaatggaaattatttttgtcatattcttcattgctgttaccttcatctccatt
ttaacaacaggtgaaggagaaggaacagttggtattattctaacattagccatgaatatc
atgggtacgttgcagtgggctgtaaaccccagcatagaggtggacagcttgatgcgatcg
gtgagccgagtcttcaagtttattgacatgcctacagaagaaagtaaaccacctaccaag
tcattcaaaccatccaaggatgcccaactctcaaaagttacgattactgagaatcggcat
gtgagggaagatgatatctggccctcagggggccaaatgactgtcaaagacctcacagca
aagtatatagatggtgggaatgccatattagagaacatttccttctcaataagtcctggc
cagagggtgggcctcttgggaagaactggatcagggaaaagtactttgttatctgctctt
ttgagactggtgaacactgagggagaaatccaaatagatggcgtgtcttgggactcaatc
cctttgcaagaatggaggagagcctttggggtgatcccacagaaagtatttatattctct
ggaacatttagaaaaaacttggatccctatggacagtggaatgatcaagaaatatggaaa
gttgcggatgaggttggactcagatctgtgatagagcagtttcctgggaagctcgatttc
gtcctggtggatgggggttacgtcctaagccatggccacaagcagttgatgtgcttggcc
agatctgtcctcaggaaggcgaaaatcctgctgctcgatgaacccagtgctcatttggat
ccaataacataccaaatcattcgaagaaccctaaagcaagcgtttgcagattgcacagtg
atcctttctgaacacaggatagaagcgatgttggaatgtcaacgattcttggtcatcgag
gacagcaggctgcggcagttcgagtccatccagaggctgctgagcgagaggagcgccttc
cggcaggccatcgggccccccgagcggcccggcctcctcccgcaccggctctccagccgg
cagaggtccccttccaggatcgcggccctgaaggaggagacggaagacgaggtgcaggac
acaaggctttag

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (7)   
   KEGG PATHWAY (7)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (22)   
   KEGG ORTHOLOGY (1)   
   RefGene (16)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (3)   
   UniProt (1)   
   SWISS-PROT (1)   
   RefSeq(pep) (1)   
DNA sequence (3)   
   RefSeq(nuc) (1)   
   GenBank (1)   
   EMBL (1)   
Protein domain (19)   
   Pfam (19)   
All databases (59)   

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