KEGG   Canis lupus familiaris (dog): 612316
Entry
612316            CDS       T01007                                 
Symbol
PRKN
Name
(RefSeq) E3 ubiquitin-protein ligase parkin isoform X1
  KO
K04556  parkin [EC:2.3.2.31]
Organism
cfa  Canis lupus familiaris (dog)
Pathway
cfa04120  Ubiquitin mediated proteolysis
cfa04137  Mitophagy - animal
cfa04141  Protein processing in endoplasmic reticulum
cfa05012  Parkinson disease
cfa05014  Amyotrophic lateral sclerosis
cfa05022  Pathways of neurodegeneration - multiple diseases
Brite
KEGG Orthology (KO) [BR:cfa00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    612316 (PRKN)
   04120 Ubiquitin mediated proteolysis
    612316 (PRKN)
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    612316 (PRKN)
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    612316 (PRKN)
   05014 Amyotrophic lateral sclerosis
    612316 (PRKN)
   05022 Pathways of neurodegeneration - multiple diseases
    612316 (PRKN)
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking [BR:cfa04131]
    612316 (PRKN)
   04121 Ubiquitin system [BR:cfa04121]
    612316 (PRKN)
   03029 Mitochondrial biogenesis [BR:cfa03029]
    612316 (PRKN)
Enzymes [BR:cfa01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     612316 (PRKN)
Membrane trafficking [BR:cfa04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    612316 (PRKN)
  Aggrephagy
   Other aggrephagy associated proteins
    612316 (PRKN)
  Xenophagy
   Other xenophagy associated proteins
    612316 (PRKN)
Ubiquitin system [BR:cfa04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    612316 (PRKN)
Mitochondrial biogenesis [BR:cfa03029]
 Mitochondrial quality control factors
  Mitophagy factors
   Parkin-dependent mechanism factors
    612316 (PRKN)
SSDB
Motif
Pfam: zf-RING_14 zf-RING_12 ubiquitin IBR Rad60-SLD Rad60-SLD_2 Dsc3_N
Other DBs
NCBI-GeneID: 612316
NCBI-ProteinID: XP_855152
Ensembl: ENSCAFG00000000769
VGNC: 82293
UniProt: A0A8C0PPD2 A0A8I3MGN8
Position
1:complement(50729328..52042064)
AA seq 464 aa
MIVFVRFNSSHGFPVEVDSETSIFQLKEVVAKRQGAPVDQLRVIFAGKELRNDLTVQSCD
LDQQSIIHVVQRPWSKSQEREVPGGDGPRKAVEGSDREPESLTRVDLSSSVLPAHSVGLA
VILSDDSERVLPARRPAGRGTYNSFYVYCKGPCQRIQPGKLRVQCSTCQQATLTLAQGPS
CWDDVLIPNRMTGECHSANCPGTTAEFFFKCGAHPTSDKETSVALNLITTNSRDITCITC
TDIRSPVLVFQCNHRHVICLDCFYLYCVTRLNDRQFIYDPQLGYSLPCVAGCPNSLIKEL
HHFRILGEEQYNRYQQYGAEECVLQMGGVLCPSPGCGAGLLPEPGVRKVTCEGSNDLGCG
FIFCRECKEEYHEGECSTLFEASGAVTQAYKVDEKAAEQARWEEASKETIKKTTKPCPRC
HVPVEKNGGCMHMKCPQPQCQLEWCWTCSCEWNRTCMGDHWFDV
NT seq 1395 nt   +upstreamnt  +downstreamnt
atgatagtgttcgtcaggttcaactccagccatggtttcccagtggaggtcgattctgaa
accagcatcttccagctcaaggaggtggttgctaagcgacagggggccccggttgaccag
ttgcgtgtgattttcgctgggaaggagcttaggaatgacttgacagtgcagagctgtgac
ctggatcagcagagcatcattcacgttgtgcagagaccctggagcaaaagccaagaaagg
gaggtccctggaggagatggcccacggaaggcagtggagggctcagacagagagcctgag
agcttaacgcgtgtggacctcagcagctctgtcctcccagcccactcggtgggtctagct
gtgatcctgagcgacgactctgagagggttctgccagccagaagaccagccggtagagga
acctacaacagcttttatgtttactgcaaaggcccctgtcaaagaatacagccaggaaaa
ctgagggtgcagtgcagcacctgccagcaggcaacgctcaccttggcccagggtccatct
tgctgggacgatgtcctaatcccaaaccggatgactggtgaatgccattcggcaaactgc
cctgggactacagccgagtttttcttcaaatgtggagcacacccgacctctgacaaggaa
acgtccgtagctttgaacctgatcacaacaaacagtcgagacatcacctgcataacgtgc
actgacatcaggagccctgtcctggtttttcagtgcaaccaccgccatgtgatttgctta
gactgtttctacttgtactgtgtgacaagactaaatgacagacagtttatctatgaccct
cagcttggctactctctgccttgtgtggctggctgccccaactccttgattaaagagctc
catcacttcaggattcttggagaagagcagtacaaccgataccagcaatatggtgctgaa
gagtgtgtgttacagatggggggcgtgttgtgccccagccctggttgtggagctggactg
cttcccgagccaggcgtgaggaaggtcacttgtgaagggagtaatgatcttggctgtggg
ttcatcttttgccgggaatgtaaggaagagtaccatgaaggcgaatgcagcaccctattt
gaagcctcaggagcagtgactcaggcctacaaagttgatgagaaggcagcagagcaagct
cggtgggaagaggcctccaaagagacaatcaagaaaaccaccaagccctgtccccgttgc
catgtgcccgttgaaaaaaatggaggatgcatgcacatgaagtgcccacagccccagtgc
cagctggagtggtgctggacctgcagctgtgagtggaaccggacctgcatgggggaccac
tggttcgacgtgtag

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Ontology (5)   
   KEGG BRITE (5)   
Pathway (6)   
   KEGG PATHWAY (6)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (25)   
   KEGG ORTHOLOGY (1)   
   RefGene (19)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   VGNC (1)   
Protein sequence (7)   
   UniProt (2)   
   RefSeq(pep) (5)   
DNA sequence (5)   
   RefSeq(nuc) (5)   
Protein domain (7)   
   Pfam (7)   
All databases (57)   

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