KEGG   COMPOUND: C01912
Entry
C01912                      Compound                               
Name
Erythromycin;
Erythromycin A;
Abomacetin
Formula
C37H67NO13
Exact mass
733.4612
Mol weight
733.9268
Structure
Sequence
0 Pyk  1 Mtk  2 Mtn  3 Mte  4 Mtk  5 Mtk  6 Mtn
  Gene
[1] 0-2 eryAI [UP:Q5Y9G4]; 3,4 eryAII [UP:Q5Y9G5]; 5,6 eryAIII
    [UP:Q5Y9G6]
[2] 0-2 DEBS1 [UP:Q03131]; 3,4 DEBS2 [UP:Q03132]; 5,6 DEBS3
    [UP:Q03133]
[3] 0-2 megAI [UP:Q9F830]; 3,4 megAII [UP:Q9F829]; 5,6 megAIII
    [UP:Q9F828]
  Organism
[1] Aeromicrobium erythreum
[2] Saccharopolyspora erythraea (Streptomyces erythraeus)
[3] Micromonospora megalomicea subsp. nigra.
  Type
PK
Remark
Same as: D00140
Reaction
Pathway
map00522  Biosynthesis of 12-, 14- and 16-membered macrolides
map01052  Type I polyketide structures
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00774  Erythromycin biosynthesis, propanoyl-CoA + methylmalonyl-CoA => deoxyerythronolide B => erythromycin A/B
Enzyme
Brite
Compounds with biological roles [BR:br08001]
 Antibiotics
  Polyketides and nonribosomal peptides
   Macrolides
    C01912  Erythromycin
Lipids [BR:br08002]
 PK  Polyketides
  PK04 Macrolides and lactone polyketides
   C01912  Erythromycin
Secondary metabolites in pathway maps [br08011.html]
 Biosynthetic pathways and modules of secondary metabolites
  C01912
Prodrugs [br08324.html]
 C01912
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D10 ANTI-ACNE PREPARATIONS
   D10A ANTI-ACNE PREPARATIONS FOR TOPICAL USE
    D10AF Antiinfectives for treatment of acne
     D10AF02 Erythromycin
      D00140  Erythromycin (JP18/USP/INN) <JP/US>
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA01 Erythromycin
      D00140  Erythromycin (JP18/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA17 Erythromycin
      D00140  Erythromycin (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Erythromycin
    D00140  Erythromycin (JP18/USP/INN)
 Dermatological Agents
  Topical Anti-infectives
   Antibacterials, dermatological
    Erythromycin
     D00140  Erythromycin (JP18/USP/INN)
 Ophthalmic Agents
  Ophthalmic Anti-Infectives
   Antibacterials, Ophthalmic
    Erythromycin
     D00140  Erythromycin (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   614  Acting mainly on gram-positive bacteria and mycoplasma
    6141  Erythromycins
     D00140  Erythromycin (JP18/USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01874  14-membered ring macrolide antibiotic
    DG00436  Erythromycin
     D00140  Erythromycin
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG00436  Erythromycin
    D00140  Erythromycin
 Metabolizing enzyme inhibitor
  DG02852  CYP3A/CYP3A4 inhibitor
   DG00436  Erythromycin
    D00140  Erythromycin
 Transporter inhibitor
  DG01622  ABCB1 inhibitor
   DG00436  Erythromycin
    D00140  Erythromycin
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D00140  Erythromycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D00140  Erythromycin (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00140  Erythromycin
  D00140  Erythromycin enteric-coated tablets
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00140
 Drug transporters
  D00140
Prodrugs [br08324.html]
 D00140
Other DBs
CAS: 114-07-8
PubChem: 5020
ChEBI: 42355
LIPIDMAPS: LMPK04000006
PDB-CCD: ERY[PDBj]
3DMET: B01517
NIKKAJI: J2.892D
KCF data

ATOM        51
            1   C1y C    28.9103  -14.0865
            2   C1z C    28.9103  -12.7233
            3   C1y C    27.7262  -14.7624
            4   O2a O    30.8915  -14.8028
            5   C1x C    27.7262  -12.0417
            6   O1a O    29.9384  -11.7356
            7   C1a C    30.1926  -13.1564
            8   C1y C    27.7262  -16.1256
            9   C1a C    26.7555  -13.7407
            10  C1y C    32.4693  -14.0880
            11  C1y C    27.7262  -10.6727
            12  O2a O    28.4656  -17.4830
            13  C1y C    26.5536  -16.8073
            14  C1y C    33.6374  -14.7792
            15  O2x O    32.4813  -12.7253
            16  C5x C    26.5536   -9.9968
            17  C1a C    28.9103   -9.9968
            18  C1y C    29.9816  -17.9009
            19  C7x C    25.3695  -16.1256
            20  C1a C    26.5536  -18.1703
            21  C1y C    34.8229  -14.1176
            22  O1a O    33.6283  -16.1469
            23  C1y C    33.6717  -12.0610
            24  C1y C    25.3695  -10.6727
            25  O5x O    26.5536   -8.6336
            26  C1x C    29.9816  -19.2584
            27  O2x O    31.1658  -17.2194
            28  O7x O    25.3695  -14.7624
            29  O6a O    24.3124  -17.0729
            30  C1x C    34.8373  -12.7600
            31  N1c N    35.9958  -14.8060
            32  C1a C    33.6914  -10.7005
            33  C1y C    25.3695  -12.0417
            34  C1a C    24.1912   -9.9968
            35  C1z C    31.1658  -19.9458
            36  C1y C    32.3382  -17.9009
            37  C1y C    24.1912  -14.0865
            38  C1z C    24.1912  -12.7233
            39  O1a O    26.5536  -12.7233
            40  C1y C    32.3382  -19.2584
            41  O2a O    31.1658  -21.2686
            42  C1a C    32.6098  -20.9278
            43  C1a C    33.5224  -17.2252
            44  C1b C    23.0127  -14.7624
            45  C1a C    22.9435  -13.2892
            46  O1a O    22.9435  -12.0360
            47  O1a O    33.5224  -19.9458
            48  C1a C    32.2632  -22.2275
            49  C1a C    23.0477  -15.8829
            50  C1a C    37.2421  -14.0985
            51  C1a C    35.9864  -16.1677
BOND        53
            1     1   2 1
            2     1   3 1
            3     1   4 1 #Down
            4     2   5 1
            5     2   6 1 #Up
            6     2   7 1 #Down
            7     3   8 1
            8     3   9 1 #Down
            9    10   4 1 #Down
            10    5  11 1
            11    8  12 1 #Down
            12    8  13 1
            13   10  14 1
            14   10  15 1
            15   11  16 1
            16   11  17 1 #Down
            17   18  12 1 #Down
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   14  22 1 #Up
            22   15  23 1
            23   16  24 1
            24   16  25 2
            25   18  26 1
            26   18  27 1
            27   19  28 1
            28   19  29 2
            29   21  30 1
            30   21  31 1 #Down
            31   23  32 1 #Down
            32   24  33 1
            33   24  34 1 #Up
            34   26  35 1
            35   27  36 1
            36   28  37 1
            37   33  38 1
            38   33  39 1 #Up
            39   35  40 1
            40   35  41 1 #Down
            41   35  42 1
            42   36  43 1 #Up
            43   37  44 1 #Down
            44   38  45 1 #Down
            45   38  46 1 #Up
            46   40  47 1 #Down
            47   41  48 1
            48   44  49 1
            49   23  30 1
            50   36  40 1
            51   37  38 1
            52   31  50 1
            53   31  51 1

» Japanese version

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