| Entry |
|
|---|
| Name |
Codeine;
(5alpha,6alpha)-7,8-Didehydro-4,5-epoxy-3-methoxy-17-methylmorphinan-6-ol
|
|---|
| Formula |
C18H21NO3
|
|---|
| Exact mass |
299.1521
|
|---|
| Mol weight |
299.3642
|
|---|
| Structure |
|
|---|
| Remark |
|
|---|
| Reaction |
|
|---|
| Pathway |
| map00950 | Isoquinoline alkaloid biosynthesis |
| map00982 | Drug metabolism - cytochrome P450 |
| map01110 | Biosynthesis of secondary metabolites |
|
|---|
| Enzyme |
|
|---|
| Brite |
Phytochemical compounds [BR:br08003]
Alkaloids
Alkaloids derived from tyrosine
Isoquinoline alkaloids
C06174 Codeine
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R05 COUGH AND COLD PREPARATIONS
R05D COUGH SUPPRESSANTS, EXCL. COMBINATIONS WITH EXPECTORANTS
R05DA Opium alkaloids and derivatives
R05DA04 Codeine
C06174 Codeine
Risk category of Japanese OTC drugs [BR:br08312]
Designated second-class OTC drugs
Inorganic and organic chemicals
Codeine
C06174 Codeine
Second-class OTC drugs
Inorganic and organic chemicals
Codeine
C06174 Codeine
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01564 Opioid receptor agonist
DG01563 mu-Opioid receptor agonist
DG01076 Codeine
C06174 Codeine
Analgesic
DG01984 Opioid analgesics
DG01076 Codeine
C06174 Codeine
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG01076 Codeine
C06174 Codeine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01076 Codeine
C06174 Codeine
DG02924 UGT substrate
DG03189 UGT2B4 substrate
DG01076 Codeine
C06174 Codeine
DG03190 UGT2B7 substrate
DG01076 Codeine
C06174 Codeine
Prodrugs [br08324.html]
C06174
Narcotics and psychotropics in Japan [br08308.html]
Narcotics by Control Act Article 2 Table 1 (74 substances)
C06174
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 22
1 C1z C 26.2749 -14.7048
2 C8y C 26.2458 -13.3977
3 C1y C 27.3733 -15.3667
4 C1y C 25.1072 -15.3498
5 C1x C 27.3733 -14.0373
6 C8y C 25.1072 -12.7471
7 C8y C 27.3789 -12.7471
8 C1y C 28.5120 -14.7160
9 C2x C 27.3676 -16.6736
10 O2x O 23.8057 -13.9588
11 C1y C 25.1014 -16.6569
12 C1x C 29.6861 -14.0831
13 C8y C 25.1072 -11.4290
14 C1x C 28.5176 -13.4034
15 C8x C 27.3789 -11.4290
16 N1y N 29.6509 -15.3780
17 C2x C 26.2289 -17.3188
18 O1a O 23.9572 -17.3131
19 C8x C 26.2514 -10.7725
20 O2a O 23.9684 -10.7725
21 C1a C 22.8297 -11.4290
22 C1a C 31.0509 -15.3780
BOND 26
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1 #Up
5 2 6 2
6 2 7 1
7 3 8 1
8 3 9 1
9 4 10 1 #Down
10 4 11 1
11 5 12 1
12 6 13 1
13 7 14 1
14 7 15 2
15 8 16 1 #Up
16 9 17 2
17 11 18 1 #Down
18 13 19 2
19 13 20 1
20 20 21 1
21 6 10 1
22 8 14 1
23 11 17 1
24 12 16 1
25 15 19 1
26 16 22 1
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