KEGG   COMPOUND: C07780
Entry
C07780                      Compound                               
Name
Chlorpheniramine maleate
Formula
C16H19ClN2. C4H4O4
Exact mass
390.1346
Mol weight
390.8606
Structure
Remark
Same as: D00665
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AB Substituted alkylamines
     R06AB04 Chlorphenamine
      D00665  Chlorpheniramine maleate (JP18/USP) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  44  Allergic agents
   441  Antihistamines
    4419  Others
     D00665  Chlorpheniramine maleate (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for nervous and sensory systems
  01 Cold remedy (oral use)
   D00665  Chlorpheniramine maleate (JP18/USP)
  06 Antivertigo drugs (incl. motion/morning sickness remedies)
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for  urogenital organs and anus
  30 Hemorrhoid drugs for external use
   D00665  Chlorpheniramine maleate (JP18/USP)
 Allergic agents
  52 Antihistamine based drugs
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for integumentary system
  57 Analgesic, antipruritic, astringent, and anti-inflammatory remedies (incl. gel patches)
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for ophthalmologic use
  64 Allergy eye drops
   D00665  Chlorpheniramine maleate (JP18/USP)
  67 Eyewash
   D00665  Chlorpheniramine maleate (JP18/USP)
 Agents for otolaryngologic use
  69 Oral medicine for nasal inflammation
   D00665  Chlorpheniramine maleate (JP18/USP)
  70 Nasal sprays for inflammation
   D00665  Chlorpheniramine maleate (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP18/USP)
 Third-class OTC drugs
  Inorganic and organic chemicals
   Chlorphenamine
    D00665  Chlorpheniramine maleate (JP18/USP)
Animal drugs in Japan [BR:br08331]
 92  Agents affecting circulatory organs, respiratory organs and urinary organs
  923  Antitussives and expectorante
   9239  Other antitussives and expectorante
    C07780  Chlorpheniramine maleate
 96  Agents affecting metabolism
  968  Antiallergic agents (including nonspecific antigen preparations)
   9682  Chlorpheniramine, derivatives and preparations
    C07780  Chlorpheniramine maleate
Drug groups [BR:br08330]
 Anti-allergic agent
  DG01557  Histamine receptor antagonist
   DG01482  Histamine receptor H1 antagonist
    DG01099  Chlorphenamine
     D00665  Chlorpheniramine maleate
Drug classes [BR:br08332]
 Anti-allergic agent
  DG01482  Histamine receptor H1 antagonist
   D00665  Chlorpheniramine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH1
     D00665  Chlorpheniramine maleate (JP18/USP) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00665  Chlorpheniramine maleate
  D00665  Chlorpheniramine maleate tablets
  D00665  Chlorpheniramine maleate powder
  D00665  Chlorpheniramine maleate injection
Rx-to-OTC switch list in the USA [br08315.html]
 D00665
Other DBs
CAS: 113-92-8
PubChem: 9982
ChEBI: 3645
KCF data

ATOM        27
            1   C8x C    20.5308  -17.4126
            2   C8y C    20.5308  -18.8307
            3   C8x C    21.7590  -19.5398
            4   C8x C    22.9872  -18.8307
            5   C8y C    22.9872  -17.4126
            6   C8x C    21.7590  -16.7035
            7   C8x C    25.4435  -18.8307
            8   C8y C    25.4435  -17.4126
            9   C1c C    24.2153  -16.7035
            10  C8x C    26.6717  -19.5398
            11  C8x C    27.8998  -18.8307
            12  C8x C    27.8998  -17.4126
            13  N5x N    26.6717  -16.7035
            14  X   Cl   19.3027  -19.5398
            15  C1b C    24.2153  -15.2853
            16  C1b C    25.4456  -14.5750
            17  N1c N    25.4456  -13.1583
            18  C1a C    26.6572  -12.4586
            19  C1a C    24.2008  -12.4395
            20  C6a C    33.4785  -15.9462
            21  C2b C    32.8034  -14.7815
            22  O6a O    32.8789  -17.1864
            23  O6a O    34.8291  -15.9399
            24  C2b C    31.1865  -14.7877
            25  C6a C    30.5175  -15.9585
            26  O6a O    29.1669  -15.9585
            27  O6a O    31.1990  -17.1925
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15    2  14 1
            16    9  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   20  21 1
            22   20  22 1
            23   20  23 2
            24   21  24 2
            25   24  25 1
            26   25  26 1
            27   25  27 2

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