Entry
Name
Formula
C72H101N17O26
Exact mass
1619.7104
Mol weight
1620.6706
Structure
Mol file KCF file DB search
Sequence
0 FA 1 Trp 2 D-Asn 3 Asp 4 Thr 5 Gly 6 Orn 7 Asp 8 D-Ala 9 Asp 10 Gly 11 D-Ser 12 threo-Glu 13 Kyn (Cyclization: 4-13)
Gene
Organism
Streptomyces roseosporus [TAX:
67294 ]
Type
NRP
Remark
Comment
FA = decanonyl
12 threo-Glu is modified by L-threo-3-methyl. (i.e. L-threo-3-Methylglutamic acid, 3mGlu)
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303 ]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XX Other antibacterials
J01XX09 Daptomycin
D01080 Daptomycin (JAN/USAN/INN) <JP/US>
USP drug classification [BR:br08302 ]
Antibacterials
Antibacterials, Other
Daptomycin
D01080 Daptomycin (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301 ]
6 Agents against pathologic organisms and parasites
61 Antibiotics
611 Acting mainly on gram-positive bacteria
6119 Others
D01080 Daptomycin (JAN/USAN/INN)
Antimicrobials [BR:br08307 ]
Antibacterials
Cell membrane function inhibitor
Lipopeptide
D01080 Daptomycin (JAN/USAN/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327 ]
Antibacterials
Cell membrane function inhibitor
Lipopeptide
D01080 Daptomycin (JAN/USAN/INN)
New drug approvals in the USA [br08319.html ]
New molecular entities and new therapeutic biological products
D01080
New drug approvals in Europe [br08329.html ]
European public assessment reports (EPAR) authorised medicine
D01080
New drug approvals in Japan [br08318.html ]
Drugs with new active ingredients
D01080
New drug approvals in the USA, Europe and Japan [br08328.html ]
Approval dates by FDA, EMA and PMDA
D01080
BRITE hierarchy
Other DBs
KCF data
Show ATOM 115
1 C5a C 24.9029 -29.0891
2 N1b N 26.0809 -29.7602
3 C1c C 27.2534 -29.1222
4 C5a C 28.4244 -29.7932
5 N1b N 29.6173 -29.1556
6 C1c C 30.7884 -29.8266
7 C5a C 31.9676 -29.1888
8 N1b N 33.1386 -29.8598
9 C1c C 34.3247 -29.2153
10 C5a C 35.4958 -29.8863
11 N1b N 36.6752 -29.2485
12 C1c C 37.8460 -29.9264
13 O6a O 56.4646 -32.9656
14 C6a C 56.4767 -31.6361
15 O6a O 57.6481 -30.9719
16 C1b C 55.2969 -30.9573
17 C1c C 40.7169 -34.3618
18 N1b N 41.8184 -33.5760
19 C5a C 42.9144 -34.3761
20 C1c C 44.2830 -34.3803
21 N1b N 45.4068 -33.6228
22 C5a C 46.4977 -34.4321
23 C1c C 47.8663 -34.4413
24 N1b N 49.0110 -33.7219
25 C5a C 50.0532 -34.5659
26 N1b N 50.8060 -28.0981
27 C5a C 49.7077 -27.2987
28 C1b C 41.1943 -27.1320
29 N1b N 40.0846 -27.9834
30 C1c C 48.3526 -27.2834
31 N1b N 47.2291 -28.0510
32 C5a C 46.1309 -27.2517
33 C1c C 44.7757 -27.2298
34 N1b N 43.6659 -28.0041
35 C5a C 42.5676 -27.1438
36 C5a C 38.7115 -27.9762
37 C1c C 52.1535 -28.0430
38 C5a C 52.8247 -29.2684
39 N1b N 52.8687 -30.6013
40 C1c C 53.9785 -31.2861
41 C5a C 53.2721 -32.4432
42 N1b N 51.8435 -33.0877
43 C1b C 51.3742 -34.5782
44 C7a C 39.5299 -33.6872
45 O7a O 39.1762 -32.2716
46 C1c C 37.8743 -31.7306
47 O6a O 38.4396 -34.4878
48 O5a O 42.4859 -35.6293
49 O5a O 46.4689 -35.7593
50 O5a O 50.0310 -35.9020
51 O5a O 54.2171 -33.3950
52 O5a O 54.1477 -28.9352
53 C1a C 52.8530 -26.8963
54 O5a O 50.1451 -26.0417
55 O5a O 46.5751 -25.9879
56 C1b C 44.3672 -25.9541
57 C1b C 45.2957 -24.9927
58 C1b C 44.8938 -23.7103
59 N1a N 45.8290 -22.7418
60 O5a O 42.9890 -25.8768
61 C1a C 36.7483 -32.4938
62 O5a O 35.4775 -31.2294
63 C1b C 34.3329 -27.4848
64 C6a C 35.5236 -26.8440
65 O6a O 35.4722 -25.5137
66 O6a O 36.6893 -27.5317
67 O5a O 31.9858 -27.8527
68 C1b C 30.8305 -31.8407
69 C5a C 32.0348 -32.4551
70 O5a O 32.0823 -33.7847
71 N1a N 33.1852 -31.7417
72 O5a O 28.4061 -31.1226
73 C1b C 27.2715 -27.4528
74 C1b C 23.7128 -29.7391
75 O5a O 24.9269 -27.7597
76 C8y C 28.4626 -26.8040
77 N4x N 30.6706 -26.7873
78 C8x C 29.5806 -27.5692
79 C8y C 30.2271 -25.5839
80 C8y C 28.8755 -25.5278
81 C8x C 28.1694 -24.3920
82 C8x C 28.8228 -23.2369
83 C8x C 30.1827 -23.2175
84 C8x C 30.8796 -24.3655
85 C1b C 22.5389 -29.0694
86 C1b C 21.3526 -29.7139
87 C1b C 20.1908 -29.0364
88 C1b C 18.9964 -29.6877
89 C1b C 17.8282 -29.0102
90 C1b C 16.6379 -29.6684
91 C1b C 15.4751 -28.9842
92 C1a C 14.2917 -29.6355
93 C1b C 40.6787 -35.6876
94 C5a C 39.4917 -36.3379
95 C8y C 39.4605 -37.6603
96 O5a O 38.3222 -35.6521
97 C8x C 40.6380 -38.3420
98 C8x C 40.6766 -39.6712
99 C8x C 39.4897 -40.3214
100 C8x C 38.3132 -39.6359
101 C8y C 38.2677 -38.3066
102 C1c C 44.2795 -36.0238
103 N1a N 37.1125 -37.6194
104 O5a O 38.7266 -26.2981
105 C1b C 48.3526 -25.1065
106 C6a C 49.5026 -24.4428
107 O6a O 50.6683 -25.1161
108 O6a O 49.5027 -23.0870
109 C1b C 47.9343 -37.1624
110 O1a O 46.7417 -37.8508
111 C1b C 43.1305 -36.6842
112 C1a C 45.4761 -36.7185
113 C6a C 43.1305 -38.0447
114 O6a O 41.9687 -38.7158
115 O6a O 44.3321 -38.7385
BOND 118
1 32 55 2
2 17 18 1
3 33 56 1 #Up
4 33 34 1
5 56 57 1
6 34 35 1
7 57 58 1
8 33 32 1
9 58 59 1
10 35 28 1
11 35 60 2
12 30 27 1
13 18 19 1
14 46 61 1
15 29 36 1
16 10 62 2
17 9 10 1
18 9 63 1 #Up
19 26 37 1
20 63 64 1
21 2 3 1
22 64 65 2
23 37 38 1
24 64 66 1
25 10 11 1
26 7 67 2
27 38 39 1
28 6 68 1 #Down
29 20 21 1
30 68 69 1
31 39 40 1
32 69 70 2
33 21 22 1
34 69 71 1
35 40 41 1
36 4 72 2
37 5 6 1
38 3 73 1 #Up
39 41 42 1
40 1 74 1
41 12 11 1
42 1 75 2
43 42 43 1
44 73 76 1
45 43 25 1
46 23 22 1
47 76 80 1
48 79 77 1
49 77 78 1
50 78 76 2
51 20 19 1
52 1 2 1
53 17 44 1
54 23 24 1
55 44 45 1
56 24 25 1
57 79 80 2
58 80 81 1
59 81 82 2
60 82 83 1
61 83 84 2
62 84 79 1
63 45 46 1
64 74 85 1
65 46 12 1
66 85 86 1
67 12 36 1
68 86 87 1
69 6 7 1
70 87 88 1
71 44 47 2
72 88 89 1
73 13 14 2
74 89 90 1
75 19 48 2
76 90 91 1
77 26 27 1
78 91 92 1
79 22 49 2
80 17 93 1 #Up
81 3 4 1
82 93 94 1
83 25 50 2
84 94 95 1
85 14 15 1
86 94 96 2
87 41 51 2
88 40 16 1 #Up
89 28 29 1
90 38 52 2
91 7 8 1
92 95 97 2
93 97 98 1
94 98 99 2
95 99 100 1
96 100 101 2
97 101 95 1
98 37 53 1 #Down
99 20 102 1 #Up
100 14 16 1
101 27 54 2
102 30 31 1
103 31 32 1
104 101 103 1
105 8 9 1
106 4 5 1
107 36 104 2
108 30 105 1 #Up
109 105 106 1
110 106 107 1
111 106 108 2
112 23 109 1 #Down
113 109 110 1
114 102 111 1
115 102 112 1
116 111 113 1
117 113 114 2
118 113 115 1