KEGG   Chlorocebus sabaeus (green monkey): 103231895
Entry
103231895         CDS       T04361                                 
Symbol
ARAF
Name
(RefSeq) A-Raf proto-oncogene, serine/threonine kinase
  KO
K08845  A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
csab  Chlorocebus sabaeus (green monkey)
Pathway
csab01521  EGFR tyrosine kinase inhibitor resistance
csab01522  Endocrine resistance
csab04010  MAPK signaling pathway
csab04012  ErbB signaling pathway
csab04068  FoxO signaling pathway
csab04270  Vascular smooth muscle contraction
csab04650  Natural killer cell mediated cytotoxicity
csab04720  Long-term potentiation
csab04726  Serotonergic synapse
csab04730  Long-term depression
csab04810  Regulation of actin cytoskeleton
csab04910  Insulin signaling pathway
csab04914  Progesterone-mediated oocyte maturation
csab04928  Parathyroid hormone synthesis, secretion and action
csab05010  Alzheimer disease
csab05022  Pathways of neurodegeneration - multiple diseases
csab05034  Alcoholism
csab05160  Hepatitis C
csab05161  Hepatitis B
csab05200  Pathways in cancer
csab05205  Proteoglycans in cancer
csab05208  Chemical carcinogenesis - reactive oxygen species
csab05210  Colorectal cancer
csab05211  Renal cell carcinoma
csab05212  Pancreatic cancer
csab05213  Endometrial cancer
csab05214  Glioma
csab05215  Prostate cancer
csab05218  Melanoma
csab05219  Bladder cancer
csab05220  Chronic myeloid leukemia
csab05221  Acute myeloid leukemia
csab05223  Non-small cell lung cancer
csab05224  Breast cancer
csab05225  Hepatocellular carcinoma
csab05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:csab00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    103231895 (ARAF)
   04012 ErbB signaling pathway
    103231895 (ARAF)
   04068 FoxO signaling pathway
    103231895 (ARAF)
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    103231895 (ARAF)
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    103231895 (ARAF)
  09152 Endocrine system
   04910 Insulin signaling pathway
    103231895 (ARAF)
   04914 Progesterone-mediated oocyte maturation
    103231895 (ARAF)
   04928 Parathyroid hormone synthesis, secretion and action
    103231895 (ARAF)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    103231895 (ARAF)
  09156 Nervous system
   04726 Serotonergic synapse
    103231895 (ARAF)
   04720 Long-term potentiation
    103231895 (ARAF)
   04730 Long-term depression
    103231895 (ARAF)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    103231895 (ARAF)
   05205 Proteoglycans in cancer
    103231895 (ARAF)
   05208 Chemical carcinogenesis - reactive oxygen species
    103231895 (ARAF)
  09162 Cancer: specific types
   05210 Colorectal cancer
    103231895 (ARAF)
   05212 Pancreatic cancer
    103231895 (ARAF)
   05225 Hepatocellular carcinoma
    103231895 (ARAF)
   05226 Gastric cancer
    103231895 (ARAF)
   05214 Glioma
    103231895 (ARAF)
   05221 Acute myeloid leukemia
    103231895 (ARAF)
   05220 Chronic myeloid leukemia
    103231895 (ARAF)
   05218 Melanoma
    103231895 (ARAF)
   05211 Renal cell carcinoma
    103231895 (ARAF)
   05219 Bladder cancer
    103231895 (ARAF)
   05215 Prostate cancer
    103231895 (ARAF)
   05213 Endometrial cancer
    103231895 (ARAF)
   05224 Breast cancer
    103231895 (ARAF)
   05223 Non-small cell lung cancer
    103231895 (ARAF)
  09172 Infectious disease: viral
   05161 Hepatitis B
    103231895 (ARAF)
   05160 Hepatitis C
    103231895 (ARAF)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    103231895 (ARAF)
   05022 Pathways of neurodegeneration - multiple diseases
    103231895 (ARAF)
  09165 Substance dependence
   05034 Alcoholism
    103231895 (ARAF)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    103231895 (ARAF)
   01522 Endocrine resistance
    103231895 (ARAF)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:csab01001]
    103231895 (ARAF)
Enzymes [BR:csab01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     103231895 (ARAF)
Protein kinases [BR:csab01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   103231895 (ARAF)
SSDB
Motif
Pfam: PK_Tyr_Ser-Thr Pkinase RBD C1_1 Kinase-like zf-RING-like ABC1 Pkinase_fungal TUG-UBL1 Kdo
Other DBs
NCBI-GeneID: 103231895
NCBI-ProteinID: XP_007989735
Ensembl: ENSCSAG00000013622
UniProt: A0A0D9RME4
Position
X:44738406..44748996
AA seq 606 aa
MEPPRGPPANGAEPSRAVGTVKVYLPNKQRTVVTVRDGMSVYDSLDKALKVRGLNQDCCV
VYRLIKGRKTVTAWDTAIAPLDGEELIVEVLEDVPLTMHNFVRKTFFSLAFCDFCLKFLF
HGFRCQTCGYKFHQHCSSKVPTVCVDMSTNRQQFYHSVQDLSGGSRQHEAPSNRPLNELL
TPQGPRPHTQHCDPEHFPFPAPANAPLQRIRSTSTPNVHMVSTTAPMDSNLIQLTGQSFS
TDAASSRGGGDGTPRGSPSPASVSSGRKSPHSKSPAEQRERKSLADDKKKVKNLGYRDSG
YYWEVPPSEVQLLKRIGTGSFGTVFRGRWHGDVAVKVLKVSQPTAEQAQAFKNEMQVLRK
TRHVNILLFMGFMTRPGFAIITQWCEGSSLYHHLHVADTRFDMVQLIDVARQTAQGMDYL
HAKNIIHRDLKSNNIFLHEGLTVKIGDFGLATVKTRWSGAQPLEQPSGSVLWMAAEVIRM
QDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPK
AMRRLLSDCLKFQREERPLFPQILATIELLQRSLPKIEGNTSKPSFYQTQADELPACLLS
AARLVP
NT seq 1821 nt   +upstreamnt  +downstreamnt
atggagccaccacggggcccccctgccaatggggccgagccgtcccgggcagtgggcacc
gtcaaagtgtacctgcccaacaagcaacgcacggtggtgactgtccgggatggcatgagt
gtctacgactctctagacaaggccctgaaggtgcggggtctaaatcaggactgctgtgtg
gtctaccgactcatcaagggacgaaagacagtcactgcctgggacacagccattgctccc
ctggatggcgaggagctcattgtcgaggtccttgaagatgtcccgctgaccatgcacaat
tttgtacggaagaccttcttcagcctggcgttctgtgacttctgccttaagtttctgttc
catggcttccgttgccaaacctgtggctacaagttccaccagcattgttcctccaaggtc
cccacagtctgtgttgacatgagtaccaaccgccaacagttctaccacagtgtccaggat
ttgtccggaggctccagacaacatgaggctccctcgaaccgccccctgaatgagttgcta
accccccagggtcccaggccccacactcagcactgtgacccggagcacttccccttccct
gccccggccaacgcccccctgcagcgcatccgctccacatccactcccaacgtccatatg
gtcagcaccacggcccccatggactccaacctcatccagctcactggccagagtttcagc
actgatgctgccagtagtagaggaggtggtgatggaaccccccgggggagccccagccca
gccagcgtgtcctcggggaggaagtccccacattccaagtcaccagcagagcagcgtgag
cggaagtccttggccgatgacaagaagaaagtgaagaacctggggtaccgggactcaggc
tattactgggaagtaccacccagtgaggtgcagctgctgaagaggatcgggacgggctcg
tttggcaccgtgtttcgagggcggtggcatggcgatgtggctgtgaaggtgctcaaggtg
tcccagcccacagctgagcaggcccaagctttcaagaatgagatgcaggtgctcaggaag
acgcgacatgtcaatatcttgctgtttatgggcttcatgacccggccaggattcgccatc
atcacacagtggtgtgaaggctccagcctctaccatcacctgcatgtggccgacacacgc
ttcgacatggtccagctcatcgacgtggcgcggcagactgcccagggcatggactacctc
catgccaagaacatcatccaccgagatctcaagtctaacaacatcttcctacatgagggg
ctcacggtgaagatcggtgactttggcttggccacagtgaagactcgatggagcggggcc
cagcccttggagcagccctcaggctctgtgctgtggatggcagctgaggtgatccgtatg
caggacccgaacccctacagcttccagtcagatgtctatgcctacggggttgtgctctac
gagctcatgactggctcactgccttacagccacattggctgccgtgaccagattatcttt
atggtgggccgtggctatctgtccccggacctcagcaaaatctctagcaactgccccaag
gccatgcggcgcctgctgtctgactgcctcaagttccagcgggaggaacggcccctcttc
ccccagatcctggccacaattgagctgctgcaacggtcactccccaagattgagggaaat
acctccaaaccttccttttatcaaacccaggctgatgagttgcctgcctgcctactcagc
gcagcccgccttgtgccttag

  All links  
Ontology (3)   
   KEGG BRITE (3)   
Pathway (36)   
   KEGG PATHWAY (36)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Genome (1)   
   KEGG GENOME (1)   
Gene (5)   
   KEGG ORTHOLOGY (1)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   RefSeq(nuc) (1)   
Protein domain (10)   
   Pfam (10)   
All databases (59)   

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