| Entry |
|
|---|
| Name |
Mosapride citrate hydrate (JP18);
Mosapride citrate dihydrate;
Gasmotin (TN) |
|---|
| Formula |
C21H25ClFN3O3. C6H8O7. 2H2O
|
|---|
| Exact mass |
649.205
|
|---|
| Mol weight |
650.047
|
|---|
| Structure |
|
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| Simcomp |
|
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| Class |
Gastrointestinal agent
DG01763 Propulsive
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 2399 |
| Product (DG01285): | D01994<JP> |
|
|---|
| Efficacy |
Prokinetic, Serotonin receptor agonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A03F PROPULSIVES
A03FA Propulsives
A03FA09 Mosapride
D01994 Mosapride citrate hydrate (JP18) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
239 Miscellaneous
2399 Others
D01994 Mosapride citrate hydrate (JP18)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01763 Propulsive
DG01285 Mosapride
D01994 Mosapride citrate hydrate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01285 Mosapride
D01994 Mosapride citrate hydrate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Serotonin
HTR4
D01994 Mosapride citrate hydrate (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01994 Mosapride citrate hydrate
D01994 Mosapride citrate tablets
D01994 Mosapride citrate powder
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01994
Drug groups [BR:br08330]
Gastrointestinal agent
DG01763 Propulsive
DG01285 Mosapride
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01285 Mosapride
|
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| Other DBs |
|
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| KCF data |
ATOM 44
1 C1d C 22.8158 -18.4544
2 C1b C 21.6014 -19.1548
3 C1b C 24.0300 -19.1548
4 C6a C 23.5163 -17.2400
5 O1a O 22.1152 -17.2400
6 C6a C 20.3871 -18.5010
7 C6a C 24.0300 -20.5560
8 O6a O 22.8158 -16.0258
9 O6a O 24.9173 -17.2400
10 O6a O 19.1729 -19.2016
11 O6a O 20.3871 -17.1000
12 O6a O 25.2443 -21.2565
13 O6a O 22.8158 -21.2565
14 O0 O 14.7000 -18.8300
15 C8y C 10.7100 -13.1600
16 C8y C 10.7100 -11.7600
17 C8x C 11.9700 -11.0600
18 C8y C 13.1600 -11.7600
19 C8y C 13.1600 -13.1600
20 C8x C 11.9700 -13.8600
21 C5a C 14.3500 -13.8600
22 N1b N 15.6100 -13.1600
23 C1b C 16.8000 -13.8600
24 C1y C 17.9900 -13.1600
25 O2x O 17.9900 -11.7600
26 C1x C 19.2500 -11.0600
27 C1x C 20.4400 -11.7600
28 N1y N 20.4400 -13.1600
29 C1x C 19.2500 -13.8600
30 O2a O 14.3500 -11.0600
31 C1b C 15.6100 -11.7600
32 C1a C 16.8000 -11.0600
33 X Cl 9.5200 -13.8600
34 N1a N 9.5200 -11.0600
35 O5a O 14.3500 -15.2600
36 C1b C 21.6300 -13.8600
37 C8y C 22.8900 -13.1600
38 C8x C 22.8900 -11.7600
39 C8x C 24.0800 -11.0600
40 C8y C 25.2700 -11.7600
41 C8x C 25.2700 -13.1600
42 C8x C 24.0800 -13.8600
43 X F 26.5300 -11.0600
44 O0 O 14.7000 -18.8300
BOND 43
1 1 2 1
2 1 3 1
3 1 4 1
4 1 5 1
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 2
9 6 10 1
10 6 11 2
11 7 12 1
12 7 13 2
13 15 16 2
14 16 17 1
15 17 18 2
16 18 19 1
17 19 20 2
18 15 20 1
19 19 21 1
20 21 22 1
21 22 23 1
22 23 24 1
23 24 25 1
24 25 26 1
25 26 27 1
26 27 28 1
27 28 29 1
28 24 29 1
29 18 30 1
30 30 31 1
31 31 32 1
32 15 33 1
33 16 34 1
34 21 35 2
35 28 36 1
36 36 37 1
37 37 38 2
38 38 39 1
39 39 40 2
40 40 41 1
41 41 42 2
42 37 42 1
43 40 43 1
BRACKET 1 12.3200 -19.8800 12.3200 -17.8500
1 15.4700 -17.8500 15.4700 -19.8800
1 2
ORIGINAL 1 14
REPEAT 1 44
|
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