KEGG   Danio rerio (zebrafish): 326857
Entry
326857            CDS       T01004                                 
Symbol
gclc
Name
(RefSeq) glutamate--cysteine ligase catalytic subunit
  KO
K11204  glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
Organism
dre  Danio rerio (zebrafish)
Pathway
dre00270  Cysteine and methionine metabolism
dre00480  Glutathione metabolism
dre01100  Metabolic pathways
dre01240  Biosynthesis of cofactors
dre04216  Ferroptosis
Module
dre_M00118  Glutathione biosynthesis, glutamate => glutathione
Brite
KEGG Orthology (KO) [BR:dre00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    326857 (gclc)
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    326857 (gclc)
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    326857 (gclc)
Enzymes [BR:dre01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.2  glutamate---cysteine ligase
     326857 (gclc)
SSDB
Motif
Pfam: GCS GCS2 mRNA_triPase
Other DBs
NCBI-GeneID: 326857
NCBI-ProteinID: NP_954971
ZFIN: ZDB-GENE-030131-5056
Ensembl: ENSDARG00000013095
UniProt: Q6NV35
Position
13:2357663..2392664
AA seq 631 aa
MGLLSQGSPLNWEETKKHADHVRKHGILQFLNIYNKVKDRQKDVLKWGDEVEYMLVNMDD
QNEKVRLVLNGKEVLEILQEKGENINPNHPTLWRPEYGSYMIEGTPGQPYGGTMSEFNTV
EDNMGKRRREASSVLKKNETLLTVTAFPRLGCPGFTLPEYKPTPVEKGVSKSLFFPDEAI
NRHPRFSTLTRNIRHRRGEKVVINVPIFKDINTPSPFMEVFPEDDGEAARGAKPDHIYMD
AMGFGMGNCCLQVTFQACSISEARYLYDQLATFCPIVMALSAASPFYRGFVSDIDCRWGV
ISASVDDRTREERGLESLKNNKFRIHKSRYDSIDSYLSCCGEKYNDIELTIDEDINKQLL
DAGIDKLLAQHIAHLFIRDPLSLFQEKIHLDDENESDHFENIQSTNWQTMRFKPPPPNSE
IGWRVEFRPMEVQLTDFENSAYVVFIVLLTRVILSYKLDFLIPLSKVDENMKVAQKRNAV
QEGMFYFRKDVFKGCTPVLDRPGAAQNGLETETNDGEEFILMSIDTIINGKEGVFHGLIP
MLNSYLENMEVDVDTRCTILNYLKLIKKRASGDLMTMAKWMREFVAKHPQYKQDSVITDK
INYDLLHKCDRIAKGEEKCPELIGEPVNRGK
NT seq 1896 nt   +upstreamnt  +downstreamnt
atgggcttgctgtcacaggggtcaccgctcaactgggaagagaccaagaaacatgctgac
cacgtaagaaaacacggcatcctgcagttcctcaacatctacaataaagtcaaagaccgg
cagaaggatgtgctcaagtggggagacgaggtggagtacatgttggtgaacatggatgac
caaaatgaaaaagtccgcctagttttgaatgggaaggaggttttggaaattcttcaggaa
aagggtgaaaacatcaaccccaaccaccccacattgtggaggcctgagtatggcagctac
atgatcgagggaacaccgggtcagccgtatggcgggacgatgtcggagttcaatacggtt
gaggataacatggggaagcggaggagagaggcttcatctgtgctcaagaagaacgaaact
ctcctcacagtcacggcattccccaggttaggctgcccgggcttcaccctgccggagtac
aaacccacacctgttgaaaaaggggtttccaaatcgctgttcttcccagacgaggccatc
aaccgacacccaagattcagcactctgaccagaaacatccgccataggaggggtgaaaag
gtggtgataaacgtaccaatttttaaagatatcaacaccccgtctccattcatggaggtg
tttccagaggatgatggagaagctgctcgaggtgccaagccggatcacatctacatggac
gccatgggcttcggcatggggaactgctgcctgcaggtgaccttccaggcttgcagcatc
agtgaggctcgatatctttacgaccagctggccactttctgtcccatagtgatggctctg
agcgccgcctctccattctatcggggttttgtgtccgacatcgactgccgctggggtgtt
atctctgcatctgtggatgaccgtacccgagaggagagaggcctggagtcgctgaaaaac
aacaaattcaggatccataaatcaagatatgattcgatcgacagctacctctcctgctgt
ggagagaaatacaatgacatcgagctgaccatagatgaggacatcaacaaacagctcctt
gatgcaggcattgacaaactgctggcgcagcacattgcacatctcttcatccgcgaccct
ctgtcgctcttccaggagaagattcacttggatgatgagaacgaatcggaccactttgag
aacattcagtccaccaactggcagaccatgaggttcaagccccctccgccaaactctgag
atcggatggagagtggagttcaggccaatggaggtccagctgacagatttcgagaactct
gcttacgtggtgtttatcgttctgctcacccgcgtcatcctgtcctacaagctggatttc
ctcattccgttgtcgaaggtggatgaaaatatgaaggtagcccagaagcgaaatgccgtg
caggagggcatgttttatttccggaaggatgtctttaaaggctgtaccccagtgctggat
cggccgggcgcagctcagaatggactggagactgaaactaatgatggagaagagtttata
ctgatgagcatcgacaccatcatcaatggaaaggaaggggtttttcacgggctgatcccc
atgttgaacagctatctggagaacatggaggtggacgtggacacacgctgcacaatcctc
aactacctgaaactcatcaagaaacgagcttcaggtgatctgatgaccatggccaagtgg
atgagggagtttgttgccaaacatcctcaatataagcaggacagcgtcattacagacaaa
atcaactacgacctgctccacaagtgtgacagaatcgcaaaaggagaagaaaaatgtccg
gaactgatcggagagccggtcaacagaggaaaatga

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Ontology (2)   
   KEGG BRITE (2)   
Pathway (6)   
   KEGG PATHWAY (5)   
   KEGG MODULE (1)   
Chemical substance (8)   
   KEGG COMPOUND (8)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
Genome (1)   
   KEGG GENOME (1)   
Gene (31)   
   KEGG ORTHOLOGY (1)   
   RefGene (25)   
   NCBI-PROTEINID (1)   
   NCBI-Gene (1)   
   Ensembl (1)   
   OC (1)   
   ZFIN (1)   
Protein sequence (2)   
   UniProt (1)   
   RefSeq(pep) (1)   
DNA sequence (9)   
   RefSeq(nuc) (1)   
   GenBank (4)   
   EMBL (4)   
Protein domain (3)   
   Pfam (3)   
All databases (65)   

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