KEGG DRUG: Vancomycin

DRUG: Vancomycin

Entry

D00212                      Drug

Name

Vancomycin (USP);
Vancocin (TN)

Product

VANCOMYCIN (Xellia Pharmaceuticals USA LLC)

Formula

C66H75Cl2N9O24

Exact mass

1447.4302

Mol weight

1449.2536

Structure

Simcomp

Source

Amycolatopsis orientalis [TAX:31958], Streptomyces orientalis [TAX:31958]

Class

Antibacterial
DG01580 Glycopeptide antibiotic

Remark

Same as:

C06689

ATC code:

A07AA09 J01XA01 S01AA28

Chemical structure group:

DG00086

Product (DG00086):

D00212<US> D00926<JP/US>

Efficacy

Antibacterial, Cell wall biosynthesis inhibitor

Comment

Natural product
Glycopeptide
Vancomycin makes complex formation with D-alanyl-D-alanine of Peptidoglycan, and inhibites cross-link between protein and peptideglycan.

Target

peptidoglycan (D-Ala-D-Ala)

Pathway

ko00550

Peptidoglycan biosynthesis

Interaction

Biosynthesis

map01055

Biosynthesis of vancomycin group antibiotics

Other map

map01503

Cationic antimicrobial peptide (CAMP) resistance

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA09 Vancomycin
      D00212  Vancomycin (USP) <US>
J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01X OTHER ANTIBACTERIALS
    J01XA Glycopeptide antibacterials
     J01XA01 Vancomycin
      D00212  Vancomycin (USP) <US>
S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA28 Vancomycin
      D00212  Vancomycin (USP) <US>
Drug groups [BR:br08330]
Antibacterial
  DG01580  Glycopeptide antibiotic
   DG00086  Vancomycin
    D00212  Vancomycin
Drug classes [BR:br08332]
Antibacterial
  DG01580  Glycopeptide antibiotic
   D00212  Vancomycin
Antimicrobials [BR:br08307]
Antibacterials
  Cell wall biosynthesis inhibitor, other
   Glycopeptide
    D00212  Vancomycin (USP) <US>
Drug groups [BR:br08330]
Antibacterial
  DG01580  Glycopeptide antibiotic
   DG00086  Vancomycin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
  Cell wall biosynthesis inhibitor, other
   Glycopeptide
    DG00086  Vancomycin

Other DBs

CAS:

1404-90-6

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        101
            1   C1y C    22.1523  -23.0181
            2   C1x C    22.1616  -21.6755
            3   O2x O    23.3049  -23.6865
            4   C1z C    23.3233  -21.0234
            5   C1y C    24.4667  -23.0342
            6   C1y C    24.4759  -21.6916
            7   C1a C    22.3951  -19.9369
            8   N1a N    24.2867  -19.9500
            9   C1a C    25.6267  -23.7026
            10  O1a O    25.6451  -21.0396
            11  C8y C    19.9288  -18.7446
            12  C8y C    21.0859  -18.0770
            13  C8y C    18.7713  -18.0843
            14  O2a O    19.9371  -20.0799
            15  C8x C    21.0786  -16.7343
            16  O2x O    22.2358  -18.7373
            17  C8x C    18.7640  -16.7491
            18  O2x O    17.6068  -18.7373
            19  C1y C    18.7766  -21.8455
            20  C8y C    19.9139  -16.0667
            21  C8y C    23.4004  -18.0696
            22  C8y C    16.4420  -18.0770
            23  C1y C    18.7766  -23.1881
            24  O2x O    17.6121  -21.1779
            25  C1y C    19.9467  -13.9511
            26  C8y C    23.4004  -16.7343
            27  C8x C    24.5577  -18.7298
            28  C8y C    15.2849  -18.7373
            29  C8x C    16.4346  -16.7343
            30  C1y C    17.6268  -23.8707
            31  C1y C    16.4474  -21.8604
            32  C5x C    21.0265  -13.2760
            33  N1x N    18.7270  -13.2833
            34  C8x C    24.5577  -16.0591
            35  X   Cl   22.2358  -16.0518
            36  C8x C    25.7075  -18.0696
            37  C8x C    14.1275  -18.0843
            38  X   Cl   15.2774  -20.0726
            39  C8x C    15.2701  -16.0667
            40  C1y C    16.4546  -23.2105
            41  O1a O    17.6194  -25.1986
            42  N1x N    22.1913  -13.9511
            43  O5x O    21.0192  -11.9407
            44  C5x C    17.5695  -13.9584
            45  C8y C    25.7075  -16.7343
            46  C8y C    14.1203  -16.7491
            47  O1a O    15.2899  -23.8632
            48  C1y C    23.3411  -13.2760
            49  C1y C    16.4124  -13.2909
            50  O5x O    17.5623  -15.2937
            51  C1y C    26.8574  -16.0518
            52  C1y C    12.9555  -16.0667
            53  C8y C    23.2785  -11.9407
            54  C5x C    24.4983  -13.9435
            55  N1x N    15.2552  -13.9660
            56  C1y C    26.8499  -13.9511
            57  O1a O    28.0146  -16.7270
            58  C1y C    12.9481  -13.9733
            59  O1a O    11.7908  -16.7343
            60  C8x C    24.5058  -11.2729
            61  C8x C    22.1840  -11.2729
            62  N1x N    25.6554  -13.2685
            63  C5x C    14.1054  -13.2982
            64  C5x C    28.0073  -13.2760
            65  N1b N    11.7834  -13.3057
            66  C8y C    24.5058   -9.9303
            67  C8x C    22.1840   -9.9376
            68  O5x O    14.1678  -11.9629
            69  N1x N    27.9998  -11.9407
            70  O5x O    29.1645  -13.9511
            71  C5a C    10.6261  -13.9660
            72  C8y C    25.6703   -9.2774
            73  C8y C    23.3411   -9.2625
            74  C1y C    26.8350  -11.2729
            75  C1c C     9.4688  -13.2982
            76  O5a O    10.6187  -15.3010
            77  C8y C    26.8277   -9.9376
            78  C8y C    25.6630   -7.9347
            79  C6a C    29.0755   -9.9897
            80  C1b C     9.4615  -11.9629
            81  N1b N     8.3041  -13.9584
            82  C8x C    27.9849   -9.2625
            83  C8x C    26.8129   -7.2596
            84  O1a O    24.4983   -7.2596
            85  C8y C    27.9776   -7.9198
            86  O1a O    29.1273   -7.2375
            87  O5x O    24.5017  -15.3103
            88  O1a O    23.3357   -7.8673
            89  O6a O    30.2660  -10.6825
            90  O6a O    29.0800   -8.6255
            91  C1a C     8.3012  -15.3102
            92  C1c C     8.2758  -11.2878
            93  C1a C     7.0582  -12.0004
            94  C1a C     8.2672   -9.9349
            95  C1b C    16.4087  -11.1067
            96  C5a C    17.5830  -10.4243
            97  N1a N    18.7559  -11.0972
            98  O5a O    17.5793   -9.0391
            99  C1b C    15.2538  -21.1805
            100 O1a O    14.0910  -21.8612
            101 O2a O    20.3945  -23.8738
BOND        110
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1
            6     4   7 1 #Up
            7     4   8 1 #Down
            8     5   9 1 #Down
            9     6  10 1 #Down
            10    5   6 1
            11   11  12 1
            12   11  13 2
            13   11  14 1
            14   12  15 2
            15   12  16 1
            16   13  17 1
            17   13  18 1
            18   19  14 1 #Up
            19   15  20 1
            20   16  21 1
            21   18  22 1
            22   19  23 1
            23   19  24 1
            24   20  25 1
            25   21  26 1
            26   21  27 2
            27   22  28 1
            28   22  29 2
            29   23  30 1
            30   24  31 1
            31   25  32 1
            32   25  33 1 #Up
            33   26  34 2
            34   26  35 1
            35   27  36 1
            36   28  37 2
            37   28  38 1
            38   29  39 1
            39   30  40 1
            40   30  41 1 #Up
            41   32  42 1
            42   32  43 2
            43   33  44 1
            44   34  45 1
            45   37  46 1
            46   40  47 1 #Down
            47   42  48 1
            48   44  49 1
            49   44  50 2
            50   45  51 1
            51   46  52 1
            52   48  53 1
            53   48  54 1 #Down
            54   49  55 1
            55   51  56 1
            56   51  57 1 #Down
            57   52  58 1
            58   52  59 1 #Up
            59   53  60 1
            60   53  61 2
            61   54  62 1
            62   55  63 1
            63   56  64 1
            64   58  65 1 #Up
            65   60  66 2
            66   61  67 1
            67   63  68 2
            68   64  69 1
            69   64  70 2
            70   65  71 1
            71   66  72 1
            72   66  73 1
            73   69  74 1
            74   71  75 1
            75   71  76 2
            76   72  77 2
            77   72  78 1
            78   74  79 1 #Down
            79   75  80 1
            80   75  81 1 #Down
            81   77  82 1
            82   78  83 2
            83   78  84 1
            84   82  85 2
            85   85  86 1
            86   17  20 2
            87   31  40 1
            88   36  45 2
            89   39  46 2
            90   56  62 1 #Down
            91   58  63 1
            92   67  73 2
            93   74  77 1
            94   83  85 1
            95   54  87 2
            96   73  88 1
            97   79  89 1
            98   79  90 2
            99   81  91 1
            100  80  92 1
            101  92  93 1
            102  92  94 1
            103  49  95 1 #Up
            104  95  96 1
            105  96  97 1
            106  96  98 2
            107  31  99 1 #Up
            108  99 100 1
            109  23 101 1 #Down
            110   1 101 1 #Up

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Ontology (4)   
   KEGG BRITE (4)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (7)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   KNApSAcK (1)   
   NIKKAJI (1)   
All databases (15)   

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