 | | DRUG: Celecoxib | |
| Entry |
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| Name |
Celecoxib (JP18/USP/INN);
Celebrex (TN);
Onsenal (TN) |
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| Product |
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| Generic |
CELECOXIB (A-S Medication Solutions), CELECOXIB (A-S Medication Solutions), CELECOXIB (A-S Medication Solutions), CELECOXIB (A-S Medication Solutions), CELECOXIB (A-S Medication Solutions), CELECOXIB (A-S Medication Solutions), CELECOXIB (A-S Medication Solutions), CELECOXIB (ADVANCED RX PHARMACY OF TENNESSEE), CELECOXIB (Actavis Pharma), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Advanced Rx Pharmacy of Tennessee), CELECOXIB (Alembic Pharmaceuticals Limited), CELECOXIB (Alembic Pharmaceuticals), CELECOXIB (American Health Packaging), CELECOXIB (Amneal Pharmaceuticals LLC), CELECOXIB (Aphena Pharma Solutions - Tennessee), CELECOXIB (Aphena Pharma Solutions - Tennessee), CELECOXIB (Aphena Pharma Solutions - Tennessee), CELECOXIB (Apotex Corp.), CELECOXIB (Asclemed USA), CELECOXIB (Asclemed USA), CELECOXIB (Aurobindo Pharma Limited), CELECOXIB (AvPAK), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Bryant Ranch Prepack), CELECOXIB (Cadila Pharmaceuticals Limited), CELECOXIB (Cardinal Health 107), CELECOXIB (Chartwell RX), CELECOXIB (Cipla USA), CELECOXIB (Direct Rx), CELECOXIB (DirectRx), CELECOXIB (Direct_Rx), CELECOXIB (Direct_Rx), CELECOXIB (Direct_Rx), CELECOXIB (Direct_Rx), CELECOXIB (Direct_Rx), CELECOXIB (EMC PHARMA), CELECOXIB (EPIC PHARMA), CELECOXIB (Greenstone LLC), CELECOXIB (Lake Erie Medical DBA Quality Care Products LLC), CELECOXIB (Lupin Pharmaceuticals), CELECOXIB (Macleods Pharmaceuticals Limited), CELECOXIB (Major Pharmaceuticals), CELECOXIB (Medsource Pharmaceuticals), CELECOXIB (Micro Labs Limited), CELECOXIB (Modavar Pharmaceuticals LLC), CELECOXIB (NCS HealthCare of KY), CELECOXIB (NIVAGEN PHARMACEUTICALS), CELECOXIB (NorthStar RxLLC), CELECOXIB (Northwind Pharmaceuticals), CELECOXIB (Northwind Pharmaceuticals), CELECOXIB (Northwind Pharmaceuticals), CELECOXIB (Northwind Pharmaceuticals), CELECOXIB (Northwind Pharmaceuticals), CELECOXIB (Northwind Pharmaceuticals), CELECOXIB (NuCare Pharmaceuticals), CELECOXIB (NuCare Pharmaceuticals), CELECOXIB (NuCare Pharmaceuticals), CELECOXIB (PD-Rx Pharmaceuticals), CELECOXIB (PD-Rx Pharmaceuticals), CELECOXIB (PD-Rx Pharmaceuticals), CELECOXIB (PD-Rx Pharmaceuticals), CELECOXIB (Preferred Pharmaceuticals), CELECOXIB (Preferred Pharmaceuticals), CELECOXIB (Preferred Pharmaceuticals), CELECOXIB (Preferred Pharmaceuticals), CELECOXIB (Proficient Rx LP), CELECOXIB (Proficient Rx LP), CELECOXIB (Proficient Rx LP), CELECOXIB (Proficient Rx LP), CELECOXIB (Proficient Rx LP), CELECOXIB (Proficient Rx LP), CELECOXIB (Proficient Rx LP), CELECOXIB (Proficient Rx LP), CELECOXIB (Qingdao BAHEAL Pharmaceutical), CELECOXIB (Quality Care Products LLC), CELECOXIB (Quality Care Products), CELECOXIB (Quallent Pharmaceuticals Health LLC), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (REMEDYREPACK), CELECOXIB (RPK Pharmaceuticals), CELECOXIB (RPK Pharmaceuticals), CELECOXIB (Radha Pharmaceuticals), CELECOXIB (Redpharm Drug), CELECOXIB (ST. MARY'S MEDICAL PARK PHARMACY), CELECOXIB (ScieGen Pharmaceuticals), CELECOXIB (St Mary's Medical Park Pharmacy), CELECOXIB (St. Mary's Medical Park Pharmacy), CELECOXIB (St. Mary's Medical Park Pharmacy), CELECOXIB (Teva Pharmaceuticals USA), CELECOXIB (Tianjin Tianyao Pharmaceuticals), CELECOXIB (Torrent Pharmaceuticals Limited), CELECOXIB (Unichem Pharmaceuticals (USA)), CELECOXIB (Westminster Pharmaceuticals), CELECOXIB (Yabao Pharmaceutical), CELECOXIB (Yiling Pharmaceutical), CELECOXIB (medsource pharmaceuticals), CELECOXIB (medsource pharmaceuticals), CELECOXIB 200 MG (Proficient Rx LP) |
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| Formula |
C17H14F3N3O2S
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| Exact mass |
381.0759
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| Mol weight |
381.3722
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01922 Selective COX2 inhibitor
DG01907 Anti-inflammatory drug, coxibs
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
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| Remark |
| Therapeutic category: | 1149 |
| Product (mixture): | D12491<US> |
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| Efficacy |
Analgesic, Anti-inflammatory, COX-2 inhibitor |
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| Disease |
Rheumatoid arthritis [DS: H00630] Juvenile rheumatoid arthritis [DS: H01672] Ankylosing spondylitis [DS: H01674] |
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| Target |
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| Pathway |
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
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| Structure map |
| map07112 | 1,2-Diphenyl substitution family |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XX Other antineoplastic agents
L01XX33 Celecoxib
D00567 Celecoxib (JP18/USP/INN) <JP/US>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AH Coxibs
M01AH01 Celecoxib
D00567 Celecoxib (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Celecoxib
D00567 Celecoxib (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D00567 Celecoxib (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01922 Selective COX2 inhibitor
DG01907 Anti-inflammatory drug, coxibs
D00567 Celecoxib
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
D00567 Celecoxib
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
D00567 Celecoxib
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D00567 Celecoxib
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS2 (COX2)
D00567 Celecoxib (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00567 Celecoxib
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00567
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00567
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00567
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| Other DBs |
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| KCF data |
ATOM 26
1 C8y C 23.9641 -17.9834
2 C1d C 25.3657 -17.9834
3 N5x N 23.1231 -16.8622
4 N4y N 21.8150 -17.2826
5 C8y C 21.8150 -18.6842
6 C8x C 23.1231 -19.1047
7 X F 25.3657 -19.3850
8 X F 26.7672 -17.9834
9 X F 25.3657 -16.5819
10 C8y C 18.1709 -15.1803
11 C8x C 18.1709 -16.5819
12 C8x C 19.3856 -17.2826
13 C8y C 20.6003 -16.5819
14 C8x C 20.6003 -15.1803
15 C8x C 19.3856 -14.4795
16 C8x C 18.1709 -19.3850
17 C8y C 18.1709 -20.7866
18 C8x C 19.3856 -21.4874
19 C8x C 20.6003 -20.7866
20 C8y C 20.6003 -19.3850
21 C8x C 19.3856 -18.6842
22 C1a C 16.9572 -21.4876
23 S4a S 16.9572 -14.4793
24 O3c O 17.6570 -13.2647
25 O3c O 16.2554 -15.6942
26 N1a N 15.7415 -13.7787
BOND 28
1 1 2 1
2 1 3 2
3 3 4 1
4 4 5 1
5 5 6 2
6 1 6 1
7 2 7 1
8 2 8 1
9 2 9 1
10 10 11 2
11 11 12 1
12 12 13 2
13 13 14 1
14 14 15 2
15 10 15 1
16 13 4 1
17 16 17 2
18 17 18 1
19 18 19 2
20 19 20 1
21 20 21 2
22 16 21 1
23 20 5 1
24 17 22 1
25 10 23 1
26 23 24 2
27 23 25 2
28 23 26 1
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