| Entry |
|
|---|
| Name |
Rifapentine (USAN/INN);
Priftin (TN) |
|---|
| Abbr |
RFP |
|---|
| Product |
|
|---|
| Formula |
C47H64N4O12
|
|---|
| Exact mass |
876.4521
|
|---|
| Mol weight |
877.0307
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
|
|---|
| Remark |
|
|---|
| Efficacy |
Antibacterial, RNA polymerase inhibitor |
|---|
| Disease |
Active pulmonary tuberculosis [DS: H00342] |
|---|
| Comment |
Rifamycin derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
CYP induction: CYP3A4 [HSA: 1576], CYP2C8 [HSA: 1558], CYP2C9 [HSA: 1559]
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J04 ANTIMYCOBACTERIALS
J04A DRUGS FOR TREATMENT OF TUBERCULOSIS
J04AB Antibiotics
J04AB05 Rifapentine
D00879 Rifapentine (USAN/INN) <US>
USP drug classification [BR:br08302]
Antimycobacterials
Antituberculars
Rifapentine
D00879 Rifapentine (USAN/INN)
Drug groups [BR:br08330]
Antibacterial
DG01966 Antitubercular
DG01598 Rifamycin antibiotic
D00879 Rifapentine
Metabolizing enzyme inducer
DG01640 CYP2C8 inducer
D00879 Rifapentine
DG02886 CYP2C9 inducer
D00879 Rifapentine
DG02853 CYP3A/CYP3A4 inducer
DG01635 CYP3A4 inducer
D00879 Rifapentine
Antimicrobials [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
D00879 Rifapentine (USAN/INN) <US>
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Nucleic acid synthesis inhibitor
Rifamycin
D00879 Rifapentine (USAN/INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00879
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 63
1 C1c C 20.3018 -19.3312
2 C1c C 20.3018 -20.7483
3 O1a O 22.6637 -20.6809
4 C1c C 22.6637 -19.3312
5 C1c C 21.4490 -18.6564
6 C2b C 24.9581 -19.3312
7 C1c C 23.8109 -18.6564
8 C5a C 26.1727 -21.4232
9 C2c C 27.3200 -20.7483
10 C2b C 27.3200 -19.3312
11 C2b C 26.1727 -18.6564
12 C1a C 23.8109 -17.3067
13 C1a C 21.4490 -17.3067
14 O1a O 19.1546 -18.6564
15 C1a C 28.4672 -21.4232
16 O5a O 25.0255 -20.7483
17 N1b N 26.1727 -23.0428
18 C1c C 19.1546 -21.4232
19 O7a O 18.0074 -20.7483
20 C1c C 19.1546 -23.0428
21 C8y C 25.0255 -23.7176
22 C8y C 25.0255 -25.0673
23 C8y C 23.8109 -23.0428
24 C8y C 22.6637 -23.7176
25 C8y C 22.6637 -25.0673
26 C8y C 23.8109 -25.7421
27 C8y C 21.5164 -23.0428
28 C8y C 20.3018 -23.7176
29 C8y C 20.3018 -25.0673
30 C8y C 21.5164 -25.7421
31 O1a O 23.8109 -21.6931
32 O1a O 21.5164 -21.6931
33 C1a C 19.1546 -19.6687
34 C7a C 16.7926 -20.0735
35 C1a C 15.6454 -20.7483
36 O6a O 16.7926 -18.7238
37 C1c C 18.0074 -23.7176
38 O2a O 16.8601 -23.0428
39 C2b C 18.0074 -25.0673
40 C1a C 18.0074 -22.0980
41 C1a C 15.7129 -23.7176
42 C2b C 16.8601 -25.7421
43 O2a O 16.8601 -27.0918
44 O2x O 19.1546 -25.7421
45 C1z C 19.1546 -27.0918
46 C5x C 21.5164 -27.0918
47 C1a C 19.1546 -28.4414
48 C1a C 20.3018 -22.3679
49 O1a O 23.8109 -27.0918
50 O5x O 22.5962 -27.7666
51 C2b C 26.2037 -25.7610
52 N2b N 27.3990 -25.0842
53 N1y N 28.5704 -25.7736
54 C1x C 28.5586 -27.1608
55 C1x C 29.7620 -27.8692
56 N1y N 30.9773 -27.1814
57 C1x C 30.9890 -25.7942
58 C1x C 29.7857 -25.0857
59 C1y C 32.1862 -27.8932
60 C1x C 32.1862 -29.2932
61 C1x C 33.5177 -29.7258
62 C1x C 34.3406 -28.5932
63 C1x C 33.5177 -27.4605
BOND 68
1 1 2 1
2 4 3 1 #Down
3 4 5 1
4 1 5 1
5 6 7 1
6 4 7 1
7 8 9 1
8 9 10 2
9 10 11 1
10 6 11 2
11 7 12 1 #Up
12 5 13 1 #Down
13 1 14 1 #Down
14 9 15 1
15 8 16 2
16 8 17 1
17 2 18 1
18 18 19 1 #Up
19 18 20 1
20 17 21 1
21 21 22 1
22 21 23 2
23 23 24 1
24 24 25 1
25 25 26 1
26 24 27 2
27 27 28 1
28 28 29 2
29 29 30 1
30 25 30 2
31 23 31 1
32 27 32 1
33 2 33 1 #Up
34 19 34 1
35 34 35 1
36 34 36 2
37 26 22 2
38 20 37 1
39 37 38 1 #Down
40 37 39 1
41 20 40 1 #Down
42 38 41 1
43 39 42 2
44 42 43 1
45 29 44 1
46 44 45 1
47 43 45 1
48 30 46 1
49 45 46 1
50 45 47 1 #Down
51 28 48 1
52 26 49 1
53 50 46 2
54 22 51 1
55 51 52 2
56 52 53 1
57 53 54 1
58 54 55 1
59 55 56 1
60 56 57 1
61 57 58 1
62 53 58 1
63 56 59 1
64 59 60 1
65 60 61 1
66 61 62 1
67 62 63 1
68 59 63 1
|
|---|
