KEGG   DRUG: Telithromycin
Entry
D01078                      Drug                                   
Name
Telithromycin (JAN/USAN/INN);
Ketek (TN)
  Abbr
TEL
Formula
C43H65N5O10
Exact mass
811.4731
Mol weight
812.0037
Structure
Simcomp
Class
Antibacterial
 DG01551  Macrolide antibiotic
Metabolizing enzyme substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
 DG02852  CYP3A/CYP3A4 inhibitor
Remark
Same as: C12009
ATC code: J01FA15
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551], CYP2D6 [HSA:1565]
Interaction
CYP inhibition: CYP3A [HSA:1576 1577 1551], CYP2D6 [HSA:1565]
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA15 Telithromycin
      D01078  Telithromycin (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   D01078  Telithromycin
 Metabolizing enzyme substrate
  DG01644  CYP2D6 substrate
   D01078  Telithromycin
  DG01633  CYP3A/CYP3A4 substrate
   D01078  Telithromycin
 Metabolizing enzyme inhibitor
  DG01645  CYP2D6 inhibitor
   D01078  Telithromycin
  DG02852  CYP3A/CYP3A4 inhibitor
   D01078  Telithromycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D01078  Telithromycin (JAN/USAN/INN)
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D01078  Telithromycin (JAN/USAN/INN)
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D01078
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01078
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01078
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01078
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01078
Other DBs
CAS: 191114-48-4
PubChem: 7848141
ChEBI: 29688
LigandBox: D01078
NIKKAJI: J982.785D
KCF data

ATOM        58
            1   C8y C     9.6207  -13.9475
            2   N5x N     9.9703  -15.3170
            3   C8x C    11.3140  -15.3182
            4   N4y N    11.7920  -14.0625
            5   C8x C    10.7482  -13.2113
            6   C8x C     6.1283  -11.9268
            7   N5x N     6.1283  -13.2742
            8   C8x C     7.3099  -13.9478
            9   C8y C     8.4637  -13.2742
            10  C8x C     8.4637  -11.9268
            11  C8x C     7.3099  -11.2599
            12  C1y C    23.2549  -17.0489
            13  C5x C    22.0756  -17.7310
            14  C1y C    23.2549  -15.6908
            15  C1y C    22.0756  -19.0890
            16  C1z C    22.0756  -15.0154
            17  C7x C    20.9164  -19.7711
            18  C1x C    22.0756  -13.6518
            19  O7x O    19.7315  -19.0890
            20  C1y C    20.9164  -12.9754
            21  C1y C    19.7315  -17.7310
            22  C5x C    19.7315  -13.6518
            23  C1y C    19.7315  -15.0154
            24  O5x O    20.9146  -17.0518
            25  C1a C    23.2549  -19.7675
            26  O6a O    20.9177  -21.1311
            27  C1z C    18.5546  -17.0496
            28  C1y C    18.5519  -15.6908
            29  N1y N    16.5168  -15.2793
            30  C7x C    15.7218  -16.3778
            31  O7x O    16.5213  -17.4661
            32  C1a C    18.1989  -18.3499
            33  C1a C    18.5427  -14.3422
            34  O5x O    18.5505  -12.9683
            35  C1a C    20.9177  -11.6182
            36  O2a O    22.7497  -13.5310
            37  C1a C    23.5926  -14.3978
            38  O2a O    24.9452  -15.5328
            39  C1y C    26.4577  -16.0816
            40  C1y C    27.6539  -15.4080
            41  O2x O    26.4354  -17.4462
            42  C1y C    28.8181  -16.0953
            43  O1a O    27.6674  -14.0542
            44  C1y C    27.6255  -18.1506
            45  C1x C    28.8164  -17.4701
            46  N1c N    29.9987  -15.4248
            47  C1a C    27.6201  -19.5076
            48  C1a C    31.1704  -16.1131
            49  C1a C    30.0046  -14.0687
            50  C1a C    24.4431  -17.7279
            51  C1b C    16.5079  -13.9228
            52  C1b C    15.3329  -13.2522
            53  C1b C    14.1667  -13.9382
            54  C1b C    12.9846  -13.2676
            55  O6a O    14.3767  -16.3806
            56  C1b C    18.7693  -18.6730
            57  C1a C    18.7624  -20.0134
            58  C1a C    22.7495  -12.1562
BOND        62
            1     9   1 1
            2    10  11 1
            3    11   6 2
            4     6   7 1
            5     7   8 2
            6     1   2 1
            7     2   3 2
            8     3   4 1
            9     4   5 1
            10    5   1 2
            11    8   9 1
            12    9  10 2
            13   22  34 2
            14   15  17 1
            15   20  35 1 #Down
            16   16  18 1
            17   16  36 1 #Up
            18   17  19 1
            19   16  37 1 #Down
            20   18  20 1
            21   19  21 1
            22   20  22 1
            23   21  27 1
            24   22  23 1
            25   23  28 1
            26   13  24 2
            27   15  25 1 #Up
            28   17  26 2
            29   39  38 1 #Up
            30   39  40 1
            31   39  41 1
            32   40  42 1
            33   40  43 1 #Down
            34   41  44 1
            35   42  45 1
            36   42  46 1 #Up
            37   44  47 1 #Up
            38   46  48 1
            39   46  49 1
            40   44  45 1
            41   14  38 1 #Down
            42   12  50 1 #Up
            43   29  51 1
            44   51  52 1
            45   52  53 1
            46   12  13 1
            47   53  54 1
            48   27  28 1
            49   28  29 1 #Down
            50   29  30 1
            51   30  31 1
            52   27  31 1
            53   12  14 1
            54   30  55 2
            55   27  32 1 #Down
            56   21  56 1 #Down
            57   13  15 1
            58   56  57 1
            59   23  33 1 #Up
            60   14  16 1
            61   36  58 1
            62    4  54 1

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