| Entry |
|
|---|
| Name |
Roxithromycin (JP18/USAN/INN);
Rulide (TN) |
|---|
| Formula |
C41H76N2O15
|
|---|
| Exact mass |
836.5246
|
|---|
| Mol weight |
837.0465
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
|
|---|
| Remark |
| Therapeutic category: | 6149 |
|
|---|
| Efficacy |
Antibacterial, Protein biosynthesis inhibitor |
|---|
| Target |
50S ribosomal subunit |
|---|
| Pathway |
|
|---|
| Metabolism |
|
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| Interaction |
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
J01FA Macrolides
J01FA06 Roxithromycin
D01710 Roxithromycin (JP18/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
61 Antibiotics
614 Acting mainly on gram-positive bacteria and mycoplasma
6149 Others
D01710 Roxithromycin (JP18/USAN/INN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01874 14-membered ring macrolide antibiotic
D01710 Roxithromycin
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
D01710 Roxithromycin
Drug classes [BR:br08332]
Antibacterial
DG01551 Macrolide antibiotic
D01710 Roxithromycin
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D01710 Roxithromycin (JP18/USAN/INN) <JP>
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D01710 Roxithromycin (JP17/USAN/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01710 Roxithromycin
D01710 Roxithromycin tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01710
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 58
1 C1y C 17.9872 -14.8169
2 C1z C 17.9872 -13.4483
3 C1y C 16.7984 -15.4957
4 O2a O 19.9051 -15.5361
5 C1x C 16.7984 -12.7640
6 O1a O 19.0196 -12.4568
7 C1a C 19.2747 -13.8833
8 C1y C 16.7984 -16.8643
9 C1a C 15.8237 -14.5393
10 C1y C 21.1345 -14.8169
11 C1y C 16.7984 -11.3896
12 O2a O 17.5407 -18.2271
13 C1y C 15.6210 -17.5487
14 C1y C 21.8305 -15.9886
15 O2x O 21.8015 -13.6225
16 C2y C 15.6210 -10.7110
17 C1a C 17.9872 -10.7110
18 C1y C 18.5731 -19.3463
19 C7x C 14.4322 -16.8643
20 C1a C 15.6210 -18.9171
21 C1y C 23.1934 -15.9764
22 O1a O 21.1636 -17.1890
23 C1y C 23.1702 -13.6803
24 C1y C 14.4322 -11.3896
25 N2b N 15.6210 -9.3424
26 C1x C 18.5731 -20.7093
27 O2x O 19.7619 -18.6621
28 O7x O 14.4322 -15.4957
29 O6a O 13.3710 -17.8154
30 C1x C 23.8603 -14.7882
31 N1c N 23.8950 -17.1484
32 C1a C 23.8430 -12.4219
33 C1y C 14.4322 -12.7640
34 C1a C 13.2493 -10.7110
35 C1z C 19.7619 -21.3993
36 C1y C 20.9392 -19.3463
37 C1y C 13.2493 -14.8169
38 C1a C 24.8404 -18.5287
39 C1a C 25.2580 -17.1311
40 C1z C 13.2493 -13.4483
41 O1a O 15.6210 -13.4483
42 C1y C 20.9392 -20.7093
43 O2a O 19.7619 -22.7274
44 C1a C 21.2118 -22.3852
45 C1a C 22.1280 -18.6678
46 C1b C 12.0661 -15.4957
47 C1a C 11.9967 -14.0167
48 O1a O 11.9967 -12.7583
49 O1a O 22.1280 -21.3993
50 C1a C 20.8638 -23.6900
51 C1a C 12.1009 -16.6206
52 O2a O 16.8085 -8.6737
53 C1b C 18.0201 -9.3732
54 O2a O 19.2316 -8.6737
55 C1b C 20.4431 -9.3732
56 C1b C 21.6548 -8.6737
57 O2a O 22.8663 -9.3732
58 C1a C 24.0778 -8.6737
BOND 60
1 3 8 1
2 3 9 1 #Down
3 10 4 1 #Down
4 5 11 1
5 8 12 1 #Down
6 8 13 1
7 10 14 1
8 10 15 1
9 11 16 1
10 11 17 1 #Down
11 18 12 1 #Down
12 13 19 1
13 13 20 1 #Up
14 14 21 1
15 14 22 1 #Up
16 15 23 1
17 16 24 1
18 16 25 2
19 18 26 1
20 18 27 1
21 19 28 1
22 19 29 2
23 21 30 1
24 21 31 1 #Down
25 23 32 1 #Down
26 24 33 1
27 24 34 1 #Up
28 26 35 1
29 27 36 1
30 28 37 1
31 31 38 1
32 31 39 1
33 33 40 1
34 33 41 1 #Up
35 35 42 1
36 35 43 1 #Down
37 35 44 1 #Up
38 36 45 1 #Up
39 37 46 1 #Down
40 40 47 1 #Down
41 40 48 1 #Up
42 42 49 1 #Down
43 43 50 1
44 46 51 1
45 23 30 1
46 36 42 1
47 37 40 1
48 1 2 1
49 1 3 1
50 1 4 1 #Down
51 2 5 1
52 2 6 1 #Up
53 2 7 1 #Down
54 25 52 1
55 52 53 1
56 53 54 1
57 54 55 1
58 55 56 1
59 56 57 1
60 57 58 1
|
|---|
