| Entry |
|
|---|
| Name |
Tylosin (USP/INN);
TS;
Tylan (TN) |
|---|
| Formula |
C46H77NO17
|
|---|
| Exact mass |
915.5192
|
|---|
| Mol weight |
916.1001
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Sequence |
0 Mtk 1 Mtd 2 Mtd 3 Man 4 Mte 5 Etk 6 Mtk 7 Man |
|---|
| Type |
PK |
|---|
| Source |
Streptomyces fradiae [TAX: 1906]
|
|---|
| Class |
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
|
|---|
| Remark |
|
|---|
| Efficacy |
Antibacterial (veterinary), Protein biosynthesis inhibitor |
|---|
| Target |
50S ribosomal subunit |
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Biosynthesis |
| map00522 | Biosynthesis of 12-, 14- and 16-membered macrolides |
|
|---|
| Structure map |
|
|---|
| Brite |
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
DG01436 Tylosin
D02490 Tylosin
Antimicrobials [BR:br08307]
Antibacterials
Protein biosynthesis inhibitor
Macrolide
D02490 Tylosin (USP/INN)
Drug groups [BR:br08330]
Antibacterial
DG01551 Macrolide antibiotic
DG01876 16-Membered ring macrolide antibiotic
DG01436 Tylosin
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 64
1 C2x C 16.8389 -11.7742
2 C2x C 16.8389 -13.1787
3 C1x C 19.2969 -13.1787
4 C1y C 19.2969 -11.7742
5 C5x C 18.0328 -11.0720
6 C1y C 19.2969 -15.9877
7 C1y C 20.4907 -15.2855
8 C1y C 20.4907 -13.8810
9 C2y C 15.6451 -13.8810
10 C2x C 15.6451 -15.2855
11 C7x C 16.8389 -17.3922
12 C1x C 18.0328 -18.0944
13 C1y C 19.2969 -17.3922
14 C1y C 14.3811 -15.9877
15 C1y C 14.3811 -17.3922
16 O7x O 15.6451 -18.0944
17 O6a O 16.8389 -15.9877
18 O1a O 20.4907 -18.0944
19 O2a O 21.6845 -15.9877
20 C1b C 21.6845 -13.1787
21 C4a C 22.8784 -13.8810
22 O4a O 24.0722 -13.1787
23 C1a C 20.4907 -11.0720
24 O5x O 18.0328 -9.6675
25 C1a C 14.4513 -13.1787
26 C1b C 13.1873 -15.2855
27 O2a O 11.9232 -15.9877
28 C1y C 10.7294 -15.2152
29 O2x O 10.7294 -13.8107
30 C1y C 9.5356 -13.1085
31 C1y C 8.2715 -13.8107
32 C1y C 8.2715 -15.2152
33 C1y C 9.5356 -15.9175
34 C1b C 13.1873 -18.0944
35 C1a C 11.9934 -17.3922
36 C1a C 18.1030 -15.2855
37 C1a C 9.5356 -11.7040
38 O1a O 7.0777 -13.1085
39 O2a O 7.0777 -15.9175
40 C1a C 5.8839 -15.2152
41 O2a O 9.5356 -17.3220
42 C1a C 8.3418 -18.0242
43 C1y C 22.8784 -16.6900
44 C1y C 22.8784 -18.0944
45 C1y C 24.0722 -18.7967
46 C1y C 25.3362 -18.0944
47 C1y C 25.3362 -16.6900
48 O2x O 24.0722 -15.9877
49 O1a O 21.6845 -18.7967
50 O2a O 26.5300 -18.7967
51 C1a C 26.5300 -15.9877
52 N1c N 24.0722 -20.2013
53 C1a C 22.8784 -20.9035
54 C1a C 25.2660 -20.9035
55 C1y C 27.7941 -19.4990
56 C1x C 27.7941 -20.9035
57 C1z C 28.9879 -21.6058
58 C1y C 30.1817 -20.9035
59 C1y C 30.1817 -19.4990
60 O2x O 28.9879 -18.7967
61 C1a C 31.3755 -18.7967
62 C1a C 29.9710 -22.5889
63 O1a O 28.1452 -22.7294
64 O1a O 31.3755 -21.6058
BOND 67
1 1 2 2
2 3 4 1
3 4 5 1
4 1 5 1
5 6 7 1
6 7 8 1
7 3 8 1
8 2 9 1
9 9 10 2
10 11 12 1
11 12 13 1
12 13 6 1
13 10 14 1
14 14 15 1
15 15 16 1
16 11 16 1
17 11 17 2
18 13 18 1 #Down
19 7 19 1 #Down
20 8 20 1 #Down
21 20 21 1
22 21 22 2
23 4 23 1 #Down
24 5 24 2
25 9 25 1
26 14 26 1 #Up
27 26 27 1
28 28 27 1 #Up
29 28 29 1
30 29 30 1
31 30 31 1
32 31 32 1
33 32 33 1
34 28 33 1
35 15 34 1 #Down
36 34 35 1
37 6 36 1 #Down
38 30 37 1 #Up
39 31 38 1 #Down
40 32 39 1 #Down
41 39 40 1
42 33 41 1 #Down
43 41 42 1
44 43 44 1
45 44 45 1
46 45 46 1
47 46 47 1
48 47 48 1
49 43 48 1
50 44 49 1 #Up
51 46 50 1 #Up
52 47 51 1 #Down
53 43 19 1 #Down
54 45 52 1 #Down
55 52 53 1
56 52 54 1
57 55 50 1 #Down
58 55 56 1
59 56 57 1
60 57 58 1
61 58 59 1
62 59 60 1
63 55 60 1
64 59 61 1 #Up
65 57 62 1 #Up
66 57 63 1 #Down
67 58 64 1 #Down
|
|---|
