KEGG   DRUG: Amikacin
Entry
D02543                      Drug                                   
Name
Amikacin (USP/INN)
Formula
C22H43N5O13
Exact mass
585.2857
Mol weight
585.6025
Structure
Simcomp
Class
Antibacterial
 DG01447  Aminoglycoside antibiotic
Remark
Same as: C06820
ATC code: D06AX12 J01GB06 S01AA21
Chemical structure group: DG00403
Product (DG00403): D00865<JP/US>
Efficacy
Antibacterial, Protein biosynthesis inhibitor
Target
30S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07021  Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX12 Amikacin
      D02543  Amikacin (USP/INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB06 Amikacin
      D02543  Amikacin (USP/INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA21 Amikacin
      D02543  Amikacin (USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   DG00403  Amikacin
    D02543  Amikacin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    D02543  Amikacin (USP/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01447  Aminoglycoside antibiotic
   DG00403  Amikacin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Aminoglycoside
    DG00403  Amikacin
Other DBs
CAS: 37517-28-5
PubChem: 17396714
ChEBI: 2637
PDB-CCD: AKN[PDBj]
LigandBox: D02543
NIKKAJI: J19.345C
KCF data

ATOM        40
            1   C1y C    16.3913  -20.1724
            2   C1y C    16.3913  -21.5733
            3   C1y C    17.5820  -22.2737
            4   C1y C    18.8429  -21.5733
            5   C1y C    18.8429  -20.1724
            6   O2x O    17.5820  -19.4719
            7   O2a O    20.0336  -19.4719
            8   C1y C    21.2244  -18.7714
            9   C1y C    22.4152  -19.4719
            10  C1x C    23.6760  -18.7714
            11  C1y C    23.6760  -17.3705
            12  C1y C    22.4152  -16.6701
            13  C1y C    21.2244  -17.3705
            14  O2a O    22.4152  -15.2692
            15  C1y C    23.6060  -14.5687
            16  C1b C    15.2005  -19.4719
            17  O1a O    14.0097  -20.1724
            18  O1a O    15.2005  -22.2737
            19  N1a N    17.5820  -23.6746
            20  O1a O    20.0336  -22.2737
            21  N1b N    22.4152  -20.8728
            22  C5a C    23.6060  -21.5733
            23  C1c C    24.8668  -20.8728
            24  C1b C    26.0576  -21.5733
            25  C1b C    27.2483  -20.8728
            26  N1a N    28.5091  -21.5733
            27  O2x O    24.8668  -15.2692
            28  C1y C    26.0576  -14.5687
            29  C1y C    26.0576  -13.1678
            30  C1y C    24.7967  -12.4673
            31  C1y C    23.6060  -13.1678
            32  C1b C    27.3184  -15.2692
            33  N1a N    27.3184  -16.6701
            34  O1a O    27.2483  -12.3973
            35  O1a O    24.7967  -11.0664
            36  O1a O    22.4152  -12.4673
            37  O5a O    23.6060  -22.9742
            38  O1a O    24.8668  -19.4719
            39  N1a N    24.7967  -16.6701
            40  O1a O    20.0336  -16.6701
BOND        42
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     5   7 1 #Down
            8     8   7 1 #Down
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15   12  14 1 #Down
            16   15  14 1 #Down
            17    1  16 1 #Up
            18   16  17 1
            19    2  18 1 #Down
            20    3  19 1 #Up
            21    4  20 1 #Down
            22    9  21 1 #Up
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   15  27 1
            29   27  28 1
            30   28  29 1
            31   29  30 1
            32   30  31 1
            33   15  31 1
            34   28  32 1 #Up
            35   32  33 1
            36   29  34 1 #Down
            37   30  35 1 #Up
            38   31  36 1 #Down
            39   22  37 2
            40   23  38 1 #Up
            41   11  39 1 #Up
            42   13  40 1 #Up

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (1)   
   KEGG PATHWAY (1)   
Drug (3)   
   KEGG DGROUP (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (17)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   MASSBANK (10)   
   NIKKAJI (1)   
   PDB-CCD (1)   
All databases (24)   

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