KEGG   DRUG: Spiramycin
Entry
D05908                      Drug                                   
Name
Spiramycin (JAN/USAN/INN);
Rovamycin (TN)
Formula
C43H73N2O14R
Structure
Simcomp
Source
Streptomyces ambofaciens [TAX:1889]
Class
Antibacterial
 DG01551  Macrolide antibiotic
  DG01876  16-Membered ring macrolide antibiotic
Remark
Same as: C01754
Therapeutic category: 6419
ATC code: J01FA02
Chemical structure group: DG00602
Product (DG00602): D05908<JP> D02420<JP>
Efficacy
Antibiotic, Protein biosynthesis inhibitor
Comment
R: See Spiramycin [CPD:C01754]
Target
50S ribosomal subunit
  Pathway
ko03010  Ribosome
Interaction
Structure map
map07020  Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA02 Spiramycin
      D05908  Spiramycin (JAN/USAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  64  Parasitics (systemic)
   641  Antiprotozoans
    6419  Others
     D05908  Spiramycin (JAN/USAN/INN)
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01876  16-Membered ring macrolide antibiotic
    DG00602  Spiramycin
     D05908  Spiramycin
Drug classes [BR:br08332]
 Antibacterial
  DG01551  Macrolide antibiotic
   D05908  Spiramycin
Antimicrobials [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    D05908  Spiramycin (JAN/USAN/INN) <JP>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D05908
Drug groups [BR:br08330]
 Antibacterial
  DG01551  Macrolide antibiotic
   DG01876  16-Membered ring macrolide antibiotic
    DG00602  Spiramycin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Protein biosynthesis inhibitor
   Macrolide
    DG00602  Spiramycin
Other DBs
CAS: 8025-81-8
PubChem: 47207566
NIKKAJI: J203.517K
KCF data

ATOM        60
            1   C1y C    24.3265  -27.0478
            2   C1y C    25.4421  -27.7004
            3   O2a O    23.2154  -27.7004
            4   C1y C    24.3265  -25.7661
            5   C1y C    26.5700  -27.0478
            6   N1c N    25.4421  -28.9890
            7   C1y C    22.1055  -28.3418
            8   O2x O    25.4421  -25.1247
            9   C1a C    23.2212  -25.1247
            10  C1y C    26.5700  -25.7661
            11  O1a O    27.6868  -27.7004
            12  C1a C    26.5586  -29.6292
            13  C1a C    24.3322  -29.6292
            14  C1x C    22.1055  -29.6234
            15  O2x O    20.9775  -27.7004
            16  O2a O    28.8199  -23.1440
            17  C1z C    20.9775  -30.2761
            18  C1y C    19.8618  -28.3418
            19  C1y C    25.3798  -19.4577
            20  C1y C    19.8618  -29.6234
            21  C1a C    20.1076  -31.5066
            22  O1a O    21.8826  -31.6670
            23  C1a C    18.7566  -27.7004
            24  C1y C    25.4442  -18.1352
            25  C1y C    24.2872  -20.1276
            26  O1a O    18.7566  -30.2761
            27  C1x C    24.2234  -17.4882
            28  C1b C    26.4783  -17.4824
            29  C1y C    24.3162  -21.5188
            30  O2a O    23.2582  -19.5618
            31  C1y C    24.2234  -16.1895
            32  C4a C    27.6007  -18.1182
            33  C1x C    23.0954  -22.1142
            34  C1y C    23.0896  -15.5481
            35  C1a C    25.3333  -15.5425
            36  O4a O    28.7106  -17.4654
            37  C7x C    21.9273  -21.4672
            38  C2x C    21.9797  -16.1895
            39  O2a O    23.0896  -14.2673
            40  O7x O    20.7607  -22.1086
            41  O6a O    21.9273  -20.1788
            42  C2x C    21.9797  -17.4882
            43  C1y C    19.6100  -21.4091
            44  C2x C    20.8403  -18.1352
            45  C1x C    19.5930  -20.0467
            46  C1a C    18.5228  -22.0743
            47  C2x C    20.8699  -19.4406
            48  C1a C    23.2478  -18.2794
            49  O2a O    25.4175  -22.1938
            50  R   R    25.4187  -23.4138
            51  C1y C    21.9804  -13.6269
            52  O2x O    21.9844  -12.3512
            53  C1y C    20.8751  -11.7107
            54  C1y C    19.7659  -12.3512
            55  C1x C    19.7659  -13.6320
            56  C1x C    20.8751  -14.2724
            57  C1a C    20.8751  -10.4299
            58  N1c N    18.6567  -11.7107
            59  C1a C    18.6567  -10.4299
            60  C1a C    17.5474  -12.3512
BOND        63
            1    19  25 1
            2    20  26 1 #Up
            3    24  27 1
            4    24  28 1 #Down
            5    25  29 1
            6    25  30 1 #Down
            7    27  31 1
            8    28  32 1
            9    29  33 1
            10   31  34 1
            11   31  35 1 #Down
            12   32  36 2
            13   33  37 1
            14   34  38 1
            15   34  39 1 #Down
            16   37  40 1
            17   37  41 2
            18   38  42 2
            19   40  43 1
            20   42  44 1
            21   43  45 1
            22   43  46 1 #Down
            23   44  47 2
            24    8  10 1
            25   18  20 1
            26   45  47 1
            27   30  48 1
            28    1   2 1
            29    1   3 1 #Down
            30    1   4 1
            31    2   5 1
            32    2   6 1 #Up
            33    7   3 1 #Up
            34    4   8 1
            35    4   9 1 #Up
            36    5  10 1
            37    5  11 1 #Down
            38    6  12 1
            39   29  49 1 #Down
            40    6  13 1
            41   49  50 1
            42    7  14 1
            43    7  15 1
            44   51  39 1 #Up
            45   10  16 1 #Up
            46   14  17 1
            47   15  18 1
            48   19  16 1 #Down
            49   17  20 1
            50   51  52 1
            51   52  53 1
            52   53  54 1
            53   54  55 1
            54   55  56 1
            55   56  51 1
            56   17  21 1 #Down
            57   53  57 1 #Up
            58   17  22 1 #Up
            59   54  58 1 #Down
            60   18  23 1 #Down
            61   58  59 1
            62   19  24 1
            63   58  60 1

» Japanese version   » Back

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Ontology (6)   
   KEGG BRITE (6)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (1)   
   KEGG DGROUP (1)   
Chemical substance (4)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   HSDB (1)   
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