KEGG   DRUG: Indapamide hydrate
Entry
D06401                      Drug                                   
Name
Indapamide hydrate;
Tenaxil (TN)
Formula
(C16H16ClN3O3S)2. H2O
Exact mass
748.1307
Mol weight
749.6844
Structure
Class
Cardiovascular agent
 DG03231  Antihypertensive
  DG02992  Thiazide related diuretic
 DG01690  Sulfonamide diuretic
  DG02992  Thiazide related diuretic
Remark
ATC code: C03BA11
Chemical structure group: DG00269
Product (DG00269): D00345<JP/US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
    C03BA Sulfonamides, plain
     C03BA11 Indapamide
      D06401  Indapamide hydrate
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
     D06401  Indapamide hydrate
  DG01690  Sulfonamide diuretic
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
     D06401  Indapamide hydrate
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A3 (TSC)
     D06401  Indapamide hydrate
Drug groups [BR:br08330]
 Cardiovascular agent
  DG03231  Antihypertensive
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
  DG01690  Sulfonamide diuretic
   DG02992  Thiazide related diuretic
    DG00269  Indapamide
Other DBs
PubChem: 47208058
LigandBox: D06401
KCF data

ATOM        49
            1   C8x C    24.5477  -14.8319
            2   C8x C    24.5477  -16.2195
            3   C8x C    25.7494  -16.9134
            4   C8x C    26.9513  -16.2195
            5   C8y C    26.9513  -14.8319
            6   C8y C    25.7494  -14.1380
            7   N1y N    28.1531  -14.1380
            8   C1y C    27.6564  -12.7106
            9   C1x C    26.2069  -12.7742
            10  N1b N    29.3549  -14.8319
            11  C5a C    30.5568  -14.1380
            12  C1a C    28.4667  -11.6267
            13  C8y C    31.8015  -14.8565
            14  O5a O    30.5573  -12.7662
            15  C8x C    31.8016  -16.2549
            16  C8x C    33.0104  -16.9526
            17  C8y C    34.2191  -16.2547
            18  C8y C    34.2190  -14.8563
            19  C8x C    33.0102  -14.1585
            20  S4a S    35.4271  -14.1587
            21  X   Cl   35.4287  -16.9529
            22  N1a N    36.6358  -13.4609
            23  O3c O    34.7253  -12.9432
            24  O3c O    36.1208  -15.3604
            25  O0  O    40.9500  -14.7000
            26  C8x C    24.5477  -14.8319
            27  C8x C    24.5477  -16.2195
            28  C8x C    25.7494  -16.9134
            29  C8x C    26.9513  -16.2195
            30  C8y C    26.9513  -14.8319
            31  C8y C    25.7494  -14.1380
            32  C1x C    26.2069  -12.7742
            33  C1y C    27.6564  -12.7106
            34  N1y N    28.1531  -14.1380
            35  N1b N    29.3549  -14.8319
            36  C5a C    30.5568  -14.1380
            37  C8y C    31.8015  -14.8565
            38  C8x C    31.8016  -16.2549
            39  C8x C    33.0104  -16.9526
            40  C8y C    34.2191  -16.2547
            41  C8y C    34.2190  -14.8563
            42  C8x C    33.0102  -14.1585
            43  S4a S    35.4271  -14.1587
            44  N1a N    36.6358  -13.4609
            45  O3c O    34.7253  -12.9432
            46  O3c O    36.1208  -15.3604
            47  X   Cl   35.4287  -16.9529
            48  O5a O    30.5573  -12.7662
            49  C1a C    28.4667  -11.6267
BOND        52
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    9   6 1
            11   10  11 1
            12    7  10 1
            13    8  12 1
            14   11  13 1
            15   11  14 2
            16   13  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   13  19 1
            22   18  20 1
            23   17  21 1
            24   20  22 1
            25   20  23 2
            26   20  24 2
            27   26  27 2
            28   27  28 1
            29   28  29 2
            30   29  30 1
            31   30  31 2
            32   26  31 1
            33   30  34 1
            34   34  33 1
            35   33  32 1
            36   32  31 1
            37   35  36 1
            38   34  35 1
            39   33  49 1
            40   36  37 1
            41   36  48 2
            42   37  38 2
            43   38  39 1
            44   39  40 2
            45   40  41 1
            46   41  42 2
            47   37  42 1
            48   41  43 1
            49   40  47 1
            50   43  44 1
            51   43  45 2
            52   43  46 2
BRACKET     1    24.1500  -17.7100   24.1500  -10.9200
            1    38.0800  -10.9200   38.0800  -17.7100
            1  2
 ORIGINAL  1    1   2   3   4   5   6   9   8   7  10  11  13  15  16  17  18
            1   19  20  22  23  24  21  14  12
 REPEAT    1   26  27  28  29  30  31  32  33  34  35  36  37  38  39  40  41
            1   42  43  44  45  46  47  48  49

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