KEGG   DRUG: Levodopa
Entry
D00059                      Drug                                   
Name
Levodopa (JP18/USP/INN);
Dopar (TN)
Product
INBRIJA (Acorda Therapeutics)
Formula
C9H11NO4
Exact mass
197.0688
Mol weight
197.1879
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01472  Dopamine agonist
 DG01967  Antiparkinson agent
Remark
Same as: C00355
Therapeutic category: 1164
ATC code: N04BA01
Product: D00059<JP/US>
Product (mixture): D00253<JP/US> D02135<JP> D10293<JP/US>
Efficacy
Antiparkinsonian
  Disease
Parkinson disease [DS:H00057]
Parkinsonism [DS:H01600]
Comment
Dopamine precursor
Active form of prodrug: Dopamine [DR:D07870]
Target
DRD [HSA:1812 1813 1814 1815 1816] [KO:K04144 K04145 K04146 K04147 K05840]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
hsa05012  Parkinson disease
Interaction
Structure map
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04B DOPAMINERGIC AGENTS
    N04BA Dopa and dopa derivatives
     N04BA01 Levodopa
      D00059  Levodopa (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antiparkinson Agents
  Dopamine Precursors and/or L-Amino Acid Decarboxylase Inhibitors
   Levodopa
    D00059  Levodopa (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   116  Antiparkinsonian agents
    1164  Levodopas
     D00059  Levodopa (JP18/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01472  Dopamine agonist
   D00059  Levodopa
  DG01967  Antiparkinson agent
   D00059  Levodopa
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG01967  Antiparkinson agent
   D00059  Levodopa
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD
     D00059  Levodopa (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00059  Levodopa
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00059
Prodrugs [br08324.html]
 D00059
Other DBs
CAS: 59-92-7
PubChem: 7847127
ChEBI: 15765
PDB-CCD: DAH[PDBj]
LigandBox: D00059
NIKKAJI: J9.225H
KCF data

ATOM        14
            1   C8y C    22.9600  -19.2500
            2   C8y C    22.9600  -20.6500
            3   C8x C    24.1500  -18.5500
            4   O1a O    21.7000  -18.5500
            5   C8x C    24.1500  -21.3500
            6   O1a O    21.7000  -21.3500
            7   C8y C    25.3400  -19.2500
            8   C8x C    25.3400  -20.6500
            9   C1b C    26.6000  -18.6200
            10  C1c C    27.7900  -19.2500
            11  C6a C    28.9800  -18.6200
            12  N1a N    27.7900  -20.6500
            13  O6a O    30.2400  -19.2500
            14  O6a O    28.9800  -17.2200
BOND        14
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     5   8 1
            8     7   9 1
            9     9  10 1
            10   10  11 1
            11   10  12 1 #Up
            12   11  13 1
            13   11  14 2
            14    7   8 2

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Ontology (9)   
   KEGG BRITE (9)   
Pathway (1)   
   KEGG PATHWAY (1)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (3)   
   KEGG DGROUP (2)   
   LigandBox (1)   
Chemical substance (8)   
   KEGG COMPOUND (1)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   KNApSAcK (1)   
   NIKKAJI (1)   
   PDB-CCD (1)   
Gene (10)   
   KEGG ORTHOLOGY (5)   
   KEGG GENES (5)   
All databases (33)   

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