 | | DRUG: Progesterone | |
| Entry |
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| Name |
Progesterone (JP18/USP/INN);
Crinone (TN);
Prometrium (TN) |
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| Product |
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| Generic |
PROGESTERONE (A-S Medication Solutions), PROGESTERONE (A-S Medication Solutions), PROGESTERONE (A-S Medication Solutions), PROGESTERONE (A-S Medication Solutions), PROGESTERONE (Amneal Pharmaceuticals LLC), PROGESTERONE (Asclemed USA), PROGESTERONE (Asclemed USA), PROGESTERONE (Asclemed USA), PROGESTERONE (Asclemed USA), PROGESTERONE (Asclemed USA), PROGESTERONE (Aurobindo Pharma Limited), PROGESTERONE (Bionpharma), PROGESTERONE (Bionpharma), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Bryant Ranch Prepack), PROGESTERONE (Direct Rx), PROGESTERONE (Dr. Reddy's Laboratories), PROGESTERONE (Eugia US LLC), PROGESTERONE (Fresenius Kabi USA), PROGESTERONE (Northstar Rx LLC), PROGESTERONE (Northwind Pharmaceuticals), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (NuCare Pharmaceuticals), PROGESTERONE (Preferred Pharmaceuticals), PROGESTERONE (Proficient Rx LP), PROGESTERONE (Proficient Rx LP), PROGESTERONE (Proficient Rx LP), PROGESTERONE (Proficient Rx LP), PROGESTERONE (REMEDYREPACK), PROGESTERONE (REMEDYREPACK), PROGESTERONE (REMEDYREPACK), PROGESTERONE (RPK Pharmaceuticals), PROGESTERONE (RPK Pharmaceuticals), PROGESTERONE (West-Ward Pharmaceuticals Corp), PROGESTERONE (XIROMED), PROGESTERONE (Xiromed), PROGESTERONE (direct rx) |
|---|
| Formula |
C21H30O2
|
|---|
| Exact mass |
314.2246
|
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| Mol weight |
314.4617
|
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| Structure |
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| Simcomp |
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| Class |
Hormonal agent
DG02004 Progesterone
DG01666 Progesterone receptor agonist
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Therapeutic category: | 2477 |
| Product (mixture): | D04459<US> |
|
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| Efficacy |
Menstruation disorder agent, Luteal replacement, Progesterone receptor agonist |
|---|
| Target |
|
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| Pathway |
| hsa04914 | Progesterone-mediated oocyte maturation |
|
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| Metabolism |
Enzyme: CYP3A4 [HSA: 1576], CYP2C19 [HSA: 1557]
|
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| Interaction |
|
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| Structure map |
| map07225 | Glucocorticoid and mineralocorticoid receptor agonists/antagonists |
| map07226 | Progesterone, androgen and estrogen receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G03 SEX HORMONES AND MODULATORS OF THE GENITAL SYSTEM
G03D PROGESTOGENS
G03DA Pregnen (4) derivatives
G03DA04 Progesterone
D00066 Progesterone (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Hormonal Agents, Stimulant/Replacement/Modifying (Sex Hormones/Modifiers)
Progestins
Progesterone
D00066 Progesterone (JP18/USP/INN)
Infertility Agents
Progesterone
D00066 Progesterone (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
24 Hormones
247 Estrogen and progesterone preparations
2477 Progesterones
D00066 Progesterone (JP18/USP/INN)
Drug groups [BR:br08330]
Hormonal agent
DG02004 Progesterone
D00066 Progesterone
DG01666 Progesterone receptor agonist
D00066 Progesterone
Metabolizing enzyme substrate
DG01639 CYP2C19 substrate
D00066 Progesterone
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
D00066 Progesterone
Drug classes [BR:br08332]
Endocrine and hormonal agent
DG02004 Progesterone
D00066 Progesterone
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Estrogen like receptors
3-Ketosteroid receptor
NR3C3 (PGR)
D00066 Progesterone (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00066 Progesterone
D00066 Progesterone injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00066
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| Other DBs |
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| KCF data |
ATOM 23
1 C1y C 23.0350 -18.9936
2 C1y C 24.2088 -19.6769
3 C1z C 21.8554 -19.6827
4 C1x C 23.0233 -17.6271
5 C1y C 25.4002 -18.9819
6 C1x C 24.1913 -21.0784
7 C2y C 21.8554 -21.0375
8 C1x C 20.6873 -19.0112
9 C1a C 21.8437 -18.2754
10 C1x C 24.2030 -16.9322
11 C1z C 25.4060 -17.6097
12 C1x C 27.7653 -18.9936
13 C1x C 23.0409 -21.7092
14 C2x C 20.6873 -21.7150
15 C1x C 19.5194 -19.6827
16 C1y C 26.5974 -16.9263
17 C1a C 25.3943 -16.2081
18 C1x C 27.7712 -17.6213
19 C5x C 19.5194 -21.0375
20 C5a C 26.6032 -15.5948
21 O5x O 18.3690 -21.6975
22 C1a C 25.3885 -14.8823
23 O5a O 27.8121 -14.8882
BOND 26
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 3 9 1 #Up
9 4 10 1
10 5 11 1
11 5 12 1
12 6 13 1
13 7 14 2
14 8 15 1
15 11 16 1
16 11 17 1 #Up
17 12 18 1
18 14 19 1
19 16 20 1 #Up
20 19 21 2
21 20 22 1
22 20 23 2
23 7 13 1
24 10 11 1
25 15 19 1
26 16 18 1
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