KEGG   DRUG: Epinephrine
Entry
D00095                      Drug                                   
Name
Epinephrine (USP/INN);
Adrenaline (JP18);
Adrenalin (TN);
Auvi-q (TN);
Epipen (TN)
Product
ADRENALIN (EPINEPHRINE) (HF Acquisition Co LLC), ADRENALIN (Henry Schein), ADRENALIN (Medical Purchasing Solutions), ADRENALIN (Par Pharmaceutical), ADRENALIN (Par Pharmaceutical), ADRENALIN (Par Pharmaceutical), ADRENALIN (REMEDYREPACK), ADRENALIN(R) (HF Acquisition Co LLC), AUVI-Q (Medical Purchasing Solutions), AUVI-Q (Medical Purchasing Solutions), AUVI-Q (kaleo), CERTA DOSE EPINEPHRINE CONVENIENCE KIT (CD Acquisitions), EPINEPHRINE (A-S Medication Solutions), EPINEPHRINE (A-S Medication Solutions), EPINEPHRINE (BPI Labs), EPINEPHRINE (BPI Labs), EPINEPHRINE (BPI Labs), EPINEPHRINE (BPI Labs), EPINEPHRINE (HF Acquisition Co LLC), EPINEPHRINE (HF Acquisition Co LLC), EPINEPHRINE (HF Acquisition Co LLC), EPINEPHRINE (HF Acquisition Co LLC), EPINEPHRINE (HF Acquisition Co LLC), EPINEPHRINE (Henry Schein), EPINEPHRINE (Hospira), EPINEPHRINE (International Medication Systems), EPINEPHRINE (Medical Purchasing Solutions), EPINEPHRINE (Medical Purchasing Solutions), EPINEPHRINE (Medical Purchasing Solutions), EPINEPHRINE (Mylan Specialty L.P.), EPINEPHRINE (REMEDYREPACK), EPINEPHRINE (REMEDYREPACK), EPINEPHRINE CONVENIENCE KIT (HF Acquisition Co LLC), EPINEPHRINE PROFESSIONAL EMS (Focus Health Group), EPIPEN (Asclemed USA), EPIPEN (REMEDYREPACK)
  Generic
EPINEPHRINE (A-S Medication Solutions), EPINEPHRINE (A-S Medication Solutions), EPINEPHRINE (A-S Medication Solutions), EPINEPHRINE (Advanced Rx Pharmacy of Tennessee), EPINEPHRINE (American Regent), EPINEPHRINE (Amneal Pharmaceuticals of New York LLC), EPINEPHRINE (Asclemed USA), EPINEPHRINE (Bryant Ranch Prepack), EPINEPHRINE (HF Acquisition Co LLC), EPINEPHRINE (International Medication Systems), EPINEPHRINE (Medical Purchasing Solutions), EPINEPHRINE (Medical Purchasing Solutions), EPINEPHRINE (Mylan Specialty L.P.), EPINEPHRINE (REMEDYREPACK), EPINEPHRINE (REMEDYREPACK), EPINEPHRINE (REMEDYREPACK), EPINEPHRINE (REMEDYREPACK), EPINEPHRINE (Teva Pharmaceuticals USA)
Formula
C9H13NO3
Exact mass
183.0895
Mol weight
183.2044
Structure
Simcomp
Class
Cardiovascular agent
 DG01703  Cardiotonic
  DG01699  Catecholamine cardiotonic
 DG01456  Adrenergic receptor agonist
 DG01951  Catecholamine adrenergic receptor agonist
Metabolizing enzyme substrate
 DG01592  COMT substrate
 DG02917  MAO substrate
Remark
Same as: C00788
Therapeutic category: 2451
ATC code: A01AD01 B02BC09 C01CA24 R01AA14 R03AA01 S01EA01
Chemical structure group: DG00013
Product (DG00013): D00095<JP/US>
Product (mixture): D04052<JP/US> D11290<US> D11569<US>
Efficacy
Bronchodilator, Vasoconstrictor, Adrenergic receptor agonist
  Disease
Anaphylaxis [DS:H01359]
Comment
Catecholamine derivative
Target
ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]
ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]
ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04022  cGMP-PKG signaling pathway
hsa04024  cAMP signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion
Metabolism
Enzyme: COMT [HSA:1312], MAO [HSA:4128 4129]
Interaction
Structure map
map07214  beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AD Other agents for local oral treatment
     A01AD01 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 B BLOOD AND BLOOD FORMING ORGANS
  B02 ANTIHEMORRHAGICS
   B02B VITAMIN K AND OTHER HEMOSTATICS
    B02BC Local hemostatics
     B02BC09 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES
    C01CA Adrenergic and dopaminergic agents
     C01CA24 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AA Sympathomimetics, plain
     R01AA14 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AA Alpha- and beta-adrenoreceptor agonists
     R03AA01 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EA Sympathomimetics in glaucoma therapy
     S01EA01 Epinephrine
      D00095  Epinephrine (USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Epinephrine
    D00095  Epinephrine (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   245  Adrenal hormone preparations
    2451  Epinephrines
     D00095  Epinephrine (USP/INN); Adrenaline (JP18)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Adrenaline (Epinephrine)
    D00095  Epinephrine (USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00013  Epinephrine
     D00095  Epinephrine
  DG01456  Adrenergic receptor agonist
   DG00013  Epinephrine
    D00095  Epinephrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG00013  Epinephrine
    D00095  Epinephrine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00013  Epinephrine
    D00095  Epinephrine
  DG02917  MAO substrate
   DG00013  Epinephrine
    D00095  Epinephrine
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRA1
     D00095  Epinephrine (USP/INN) <JP/US>
    ADRA2
     D00095  Epinephrine (USP/INN) <JP/US>
    ADRB
     D00095  Epinephrine (USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00095  Adrenaline
  D00095  Adrenaline solution
  D00095  Adrenaline injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00095
Prodrugs [br08324.html]
 D00095
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01703  Cardiotonic
   DG01699  Catecholamine cardiotonic
    DG00013  Epinephrine
  DG01456  Adrenergic receptor agonist
   DG00013  Epinephrine
  DG01951  Catecholamine adrenergic receptor agonist
   DG00013  Epinephrine
 Metabolizing enzyme substrate
  DG01592  COMT substrate
   DG00013  Epinephrine
  DG02917  MAO substrate
   DG00013  Epinephrine
Other DBs
CAS: 51-43-4
PubChem: 7847163
ChEBI: 28918
PDB-CCD: ALE[PDBj]
LigandBox: D00095
NIKKAJI: J9.224J
KCF data

ATOM        13
            1   C8y C    21.2028  -17.0133
            2   C8x C    21.2028  -18.4284
            3   C8x C    19.9857  -16.3144
            4   C1c C    22.4083  -16.3144
            5   C8x C    19.9857  -19.1389
            6   C8y C    18.7742  -17.0133
            7   C1b C    23.6196  -17.0075
            8   O1a O    22.4083  -14.9168
            9   C8y C    18.7742  -18.4284
            10  N1b N    24.8191  -16.3087
            11  O1a O    17.5630  -19.1156
            12  O1a O    17.5677  -16.3165
            13  C1a C    26.0284  -17.0006
BOND        13
            1     1   3 1
            2     1   4 1
            3     2   5 1
            4     3   6 2
            5     4   7 1
            6     4   8 1 #Up
            7     5   9 2
            8     7  10 1
            9     9  11 1
            10    6   9 1
            11    6  12 1
            12    1   2 2
            13   10  13 1

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