| Entry |
|
|---|
| Name |
Epoprostenol (USAN/INN);
Prostaglandin I2;
Prostacyclin;
Epoprostenol (TN) |
|---|
| Formula |
C20H32O5
|
|---|
| Exact mass |
352.225
|
|---|
| Mol weight |
352.4651
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
Hormonal agent
DG01961 Prostaglandin derivative
DG01810 Prostacycline derivative
|
|---|
| Remark |
| Product (DG00157): | D01337<JP/US> |
|
|---|
| Efficacy |
Platelet aggregation inhibitor, Prostaglandin I2 receptor agonist |
|---|
| Disease |
Pulmonary arterial hypertension [DS: H01621] |
|---|
| Comment |
Eicosanoids, Prostacycline derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07228 | Eicosanoid receptor agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
B BLOOD AND BLOOD FORMING ORGANS
B01 ANTITHROMBOTIC AGENTS
B01A ANTITHROMBOTIC AGENTS
B01AC Platelet aggregation inhibitors excl. heparin
B01AC09 Epoprostenol
D00106 Epoprostenol (USAN/INN)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG00157 Epoprostenol
D00106 Epoprostenol
Hormonal agent
DG01961 Prostaglandin derivative
DG01810 Prostacycline derivative
DG00157 Epoprostenol
D00106 Epoprostenol
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Prostacyclin
PTGIR
D00106 Epoprostenol (USAN/INN)
Drug groups [BR:br08330]
Blood modifier agent
DG01950 Antithrombotic agent
DG01712 Antiplatelet agent
DG00157 Epoprostenol
Hormonal agent
DG01961 Prostaglandin derivative
DG01810 Prostacycline derivative
DG00157 Epoprostenol
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 25
1 C1y C 23.9400 -30.3100
2 C1y C 22.6100 -29.8900
3 C1y C 23.9400 -31.7100
4 C1x C 24.6400 -29.0500
5 O2x O 22.6100 -28.4200
6 C1x C 21.8400 -31.0100
7 C1y C 22.6800 -32.1300
8 C2b C 25.1300 -32.4100
9 C2y C 23.9400 -27.7900
10 O1a O 22.1900 -33.4600
11 C2b C 26.3200 -31.7100
12 C2b C 25.1300 -27.0900
13 C1c C 27.5100 -32.4100
14 C1b C 28.7700 -31.7100
15 O1a O 27.5100 -33.7400
16 C1b C 29.9600 -32.4100
17 C1b C 31.1500 -31.7100
18 C1b C 32.3400 -32.4100
19 C1a C 33.5300 -31.7100
20 C1b C 25.2000 -25.6900
21 C1b C 26.3900 -24.9900
22 C1b C 26.3900 -23.5900
23 C6a C 27.5800 -22.8900
24 O6a O 28.8400 -23.5900
25 O6a O 27.5800 -21.4900
BOND 26
1 1 2 1
2 1 3 1
3 1 4 1 #Down
4 2 5 1 #Down
5 2 6 1
6 3 7 1
7 3 8 1 #Up
8 4 9 1
9 7 10 1 #Down
10 8 11 2
11 9 12 2
12 11 13 1
13 13 14 1
14 13 15 1 #Down
15 14 16 1
16 16 17 1
17 17 18 1
18 18 19 1
19 5 9 1
20 6 7 1
21 12 20 1
22 20 21 1
23 21 22 1
24 22 23 1
25 23 24 2
26 23 25 1
|
|---|
