 | | DRUG: Naproxen | |
| Entry |
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| Name |
Naproxen (JP18/USP/INN);
Naprosyn (TN) |
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| Product |
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| Generic |
NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (A-S Medication Solutions), NAPROXEN (Acella Pharmaceuticals), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (Advanced Rx Pharmacy of Tennessee), NAPROXEN (American Health Packaging), NAPROXEN (Amneal Pharmaceuticals LLC), NAPROXEN (Amneal Pharmaceuticals of New York LLC), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Aphena Pharma Solutions - Tennessee), NAPROXEN (Asclemed USA), NAPROXEN (Asclemed USA), NAPROXEN (Asclemed USA), NAPROXEN (Aurobindo Pharma Limited), NAPROXEN (AvKARE), NAPROXEN (AvPAK), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Bryant Ranch Prepack), NAPROXEN (Camber Pharmaceuticals), NAPROXEN (Cameron Pharmaceuticals), NAPROXEN (Cipla USA), NAPROXEN (Cipla USA), NAPROXEN (DIRECT RX), NAPROXEN (DIRECT RX), NAPROXEN (DIRECT RX), NAPROXEN (Denton Pharma), NAPROXEN (Direct RX), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Direct_Rx), NAPROXEN (Exelan Pharmaceuticals), NAPROXEN (H.J. Harkins Company.), NAPROXEN (Hikma Pharmaceuticals USA), NAPROXEN (Lake Erie Medical DBA Quality Care Products LLC), NAPROXEN (MARKSANS PHARMA LIMITED), NAPROXEN (McKesson Corporation dba SKY Packaging), NAPROXEN (Medsource Pharmaceuticals), NAPROXEN (Medsource Pharmaceuticals), NAPROXEN (NCS HealthCare of KY), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (Northwind Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (NuCare Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (PD-Rx Pharmaceuticals), NAPROXEN (Pharmasource Meds), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Preferred Pharmaceuticals), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (Proficient Rx LP), NAPROXEN (QPharma), NAPROXEN (QPharma), NAPROXEN (Quality Care Products), NAPROXEN (Quality Care Products), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (REMEDYREPACK), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (RPK Pharmaceuticals), NAPROXEN (Radha Pharmaceuticals), NAPROXEN (Redpharm Drug), NAPROXEN (ST. MARY'S MEDICAL PARK PHARMACY), NAPROXEN (ST. MARY'S MEDICAL PARK PHARMACY), NAPROXEN (ScieGen Pharmaceuticals), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (St. Mary's Medical Park Pharmacy), NAPROXEN (TIME CAP LABORATORIES), NAPROXEN (Teva Pharmaceuticals USA), NAPROXEN (TruPharma LLC), NAPROXEN (Virtus Pharmaceuticals), NAPROXEN (Zydus Lifesciences Limited), NAPROXEN (Zydus Pharmaceuticals USA), NAPROXEN (medsource pharmaceuticals), NAPROXEN (medsource pharmaceuticals), NAPROXEN ORAL SUSPENSION (Novitium Pharma LLC), NAPROXEN SODIUM (Glenmark Pharmaceuticals) |
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| Formula |
C14H14O3
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| Exact mass |
230.0943
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| Mol weight |
230.2592
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| Structure |
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| Simcomp |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
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| Remark |
| Therapeutic category: | 1149 |
| Product (DG00455): | D00118<JP/US> D00970<US> |
| Product (mixture): | D11576<US> |
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| Efficacy |
Analgesic, Anti-inflammatory, Antipyretic, COX inhibitor |
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| Disease |
Rheumatoid arthritis [DS: H00630] Ankylosing spondylitis [DS: H01674] Polyarticular juvenile idiopathic arthritis [DS: H01672] Acute gout [DS: H01532] |
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| Comment |
Propionic acid derivative
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| Target |
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| Pathway |
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
G GENITO URINARY SYSTEM AND SEX HORMONES
G02 OTHER GYNECOLOGICALS
G02C OTHER GYNECOLOGICALS
G02CC Antiinflammatory products for vaginal administration
G02CC02 Naproxen
D00118 Naproxen (JP18/USP/INN) <JP/US>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE02 Naproxen
D00118 Naproxen (JP18/USP/INN) <JP/US>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA12 Naproxen
D00118 Naproxen (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Naproxen
D00118 Naproxen (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
114 Antipyretics and analgesics, anti-inflammatory agents
1149 Others
D00118 Naproxen (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
Drugs requiring guidance
New approved switch OTC drugs
Naproxen
D00118 Naproxen (JP18/USP/INN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00455 Naproxen
D00118 Naproxen
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D00118 Naproxen
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D00118 Naproxen (JP18/USP/INN) <JP/US>
PTGS2 (COX2)
D00118 Naproxen (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00118 Naproxen
Rx-to-OTC switch list in Japan [br08314.html]
D00118
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00455 Naproxen
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| Other DBs |
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| KCF data |
ATOM 17
1 C8y C 24.6254 -20.0866
2 C8y C 24.6254 -21.4127
3 C8x C 25.8119 -19.3887
4 C8x C 23.5087 -19.3887
5 C8x C 23.5087 -22.1106
6 C8x C 25.8119 -22.1106
7 C8y C 26.9983 -20.0866
8 C8x C 22.3222 -20.0866
9 C8y C 22.3222 -21.4127
10 C8x C 26.9983 -21.3429
11 C1c C 28.1848 -19.3887
12 O2a O 21.1358 -22.1106
13 C6a C 29.3015 -20.0866
14 C1a C 28.1848 -18.0626
15 C1a C 19.4607 -21.0637
16 O6a O 30.6974 -19.1793
17 O6a O 29.3015 -21.4127
BOND 18
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 5 9 2
9 6 10 2
10 7 11 1
11 9 12 1
12 11 13 1
13 11 14 1 #Down
14 12 15 1
15 13 16 1
16 13 17 2
17 7 10 1
18 8 9 1
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