| Entry |
|
|---|
| Name |
Disulfiram (JP18/USP/INN);
Antabuse (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C10H20N2S4
|
|---|
| Exact mass |
296.0509
|
|---|
| Mol weight |
296.5392
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG02884 CYP2E1 inhibitor
|
|---|
| Remark |
| Therapeutic category: | 3939 |
|
|---|
| Efficacy |
Antialcohol dependence, Aldehyde dehydrogenase inhibitor |
|---|
| Disease |
Management of selected chronic alcohol patients [DS: H01611] |
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
CYP inhibition: CYP2E1 [HSA: 1571], CYP1A2 [HSA: 1544]
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N07 OTHER NERVOUS SYSTEM DRUGS
N07B DRUGS USED IN ADDICTIVE DISORDERS
N07BB Drugs used in alcohol dependence
N07BB01 Disulfiram
D00131 Disulfiram (JP18/USP/INN) <JP/US>
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P03 ECTOPARASITICIDES, INCL. SCABICIDES, INSECTICIDES AND REPELLENTS
P03A ECTOPARASITICIDES, INCL. SCABICIDES
P03AA Sulfur containing products
P03AA04 Disulfiram
D00131 Disulfiram (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anti-Addiction/Substance Abuse Treatment Agents
Alcohol Deterrents/Anti-craving
Disulfiram
D00131 Disulfiram (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
393 Habitual intoxication agents
3939 Others
D00131 Disulfiram (JP18/USP/INN)
Drug groups [BR:br08330]
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
D00131 Disulfiram
DG02884 CYP2E1 inhibitor
D00131 Disulfiram
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dehydrogenases
ALDH
D00131 Disulfiram (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00131 Disulfiram
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00131
|
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| Other DBs |
|
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| KCF data |
ATOM 16
1 N1c N 18.9962 -16.1700
2 C2c C 20.2135 -16.8721
3 C1b C 17.7852 -16.8721
4 C1b C 18.9962 -14.7723
5 S3a S 21.4244 -16.1700
6 S0 S 20.2135 -18.2762
7 C1a C 16.5743 -16.1700
8 C1a C 17.7852 -14.0703
9 S3a S 22.8221 -16.1636
10 C2c C 24.0265 -16.8656
11 N1c N 25.2438 -16.1700
12 S0 S 24.0200 -18.2633
13 C1b C 26.4548 -16.8721
14 C1b C 25.2438 -14.7659
15 C1a C 27.6657 -16.1764
16 C1a C 26.4611 -14.0703
BOND 15
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 4 8 1
8 5 9 1
9 9 10 1
10 10 11 1
11 10 12 2
12 11 13 1
13 11 14 1
14 13 15 1
15 14 16 1
|
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