| Entry |
|
|---|
| Name |
Methotrexate (JP18/USP/INN);
Otrexup (TN);
Xatmep (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C20H22N8O5
|
|---|
| Exact mass |
454.1713
|
|---|
| Mol weight |
454.4393
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antineoplastic
DG02018 Antimetabolite
DG01978 Folic acid analog
DG01930 Dihydrofolate reductase inhibitor
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
|
|---|
| Remark |
| Product (DG00681): | D00142<JP/US> D02115<US> |
|
|---|
| Efficacy |
Antineoplastic, Antimetabolite |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07041 | Antineoplastics - antimetabolic agents |
| map07050 | Antirheumatics - DMARDs and biological agents |
|
|---|
| Other map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01B ANTIMETABOLITES
L01BA Folic acid analogues
L01BA01 Methotrexate
D00142 Methotrexate (JP18/USP/INN) <JP/US>
L04 IMMUNOSUPPRESSANTS
L04A IMMUNOSUPPRESSANTS
L04AX Other immunosuppressants
L04AX03 Methotrexate
D00142 Methotrexate (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
Antimetabolites
Methotrexate
D00142 Methotrexate (JP18/USP/INN)
Immunological Agents
Immunosuppressants
Antimetabolites, Antiproliferative
Methotrexate
D00142 Methotrexate (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
3 Agents affecting metabolism
39 Other agents affecting metabolism
399 Miscellaneous
3999 Others
D00142 Methotrexate (JP18/USP/INN)
4 Agents affecting cellular function
42 Antineoplastics
422 Antimetabolites
4222 Methotrexates
D00142 Methotrexate (JP18/USP/INN)
Drug groups [BR:br08330]
Antineoplastic
DG02018 Antimetabolite
DG01978 Folic acid analog
DG01930 Dihydrofolate reductase inhibitor
DG00681 Methotrexate
D00142 Methotrexate
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG00681 Methotrexate
D00142 Methotrexate
Drug classes [BR:br08332]
Antineoplastic
DG02018 Antimetabolite
D00142 Methotrexate
Antirheumatic agent
DG01985 Disease modifying anti-rheumatic drug (DMARD)
D00142 Methotrexate
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Dihydrofolate reductase
DHFR
D00142 Methotrexate (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00142 Methotrexate
D00142 Methotrexate tablets
D00142 Methotrexate capsules
D00142 Methotrexate for injection
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00142
Drug groups [BR:br08330]
Antineoplastic
DG02018 Antimetabolite
DG01978 Folic acid analog
DG01930 Dihydrofolate reductase inhibitor
DG00681 Methotrexate
Anti-inflammatory
DG01985 Disease modifying anti-rheumatic drug (DMARD)
DG00681 Methotrexate
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 33
1 C8y C 8.3300 -28.0700
2 N5x N 8.3300 -29.4700
3 C8y C 9.5424 -30.1700
4 C8y C 10.7549 -29.4700
5 C8y C 10.7549 -28.0700
6 N5x N 9.5424 -27.3700
7 N5x N 11.9673 -30.1700
8 C8y C 13.1797 -29.4700
9 C8x C 13.1797 -28.0700
10 N5x N 11.9673 -27.3700
11 N1a N 7.1176 -27.3700
12 N1a N 9.5424 -31.5698
13 C1b C 14.3773 -30.1615
14 N1c N 15.5656 -29.4755
15 C8y C 16.7564 -30.1631
16 C1a C 15.5657 -28.0702
17 C8x C 16.7564 -31.5698
18 C8x C 17.9688 -32.2698
19 C8y C 19.1812 -31.5698
20 C8x C 19.1812 -30.1632
21 C8x C 17.9688 -29.4631
22 C5a C 20.3928 -32.2693
23 N1b N 21.5877 -31.5793
24 O5a O 20.3929 -33.6698
25 C1c C 22.7754 -32.2649
26 C1b C 23.9665 -31.5770
27 C1b C 25.1560 -32.2638
28 C6a C 26.3461 -31.5765
29 O6a O 27.5362 -32.2635
30 C6a C 22.7755 -33.6698
31 O6a O 23.9689 -34.3588
32 O6a O 21.5440 -34.3811
33 O6a O 26.3462 -30.1702
BOND 35
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 2
9 8 9 1
10 9 10 2
11 5 10 1
12 1 11 1
13 3 12 1
14 8 13 1
15 13 14 1
16 14 15 1
17 14 16 1
18 15 17 2
19 17 18 1
20 18 19 2
21 19 20 1
22 20 21 2
23 15 21 1
24 19 22 1
25 22 23 1
26 22 24 2
27 23 25 1
28 25 26 1
29 26 27 1
30 27 28 1
31 28 29 1
32 25 30 1 #Up
33 30 31 1
34 30 32 2
35 28 33 2
|
|---|
