KEGG   DRUG: Corticotropin
Entry
D00146                      Drug                                   
Name
Corticotropin (USP/INN);
ACTH (TN);
Acthar (TN)
Product
ACTHAR (Mallinckrodt ARD LLC), PURIFIED CORTROPHIN GEL (ANI Pharmaceuticals)
Sequence
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys
Arg Arg Pro Val Lys Val Tyr Pro Asn Gly Ala Glu Asp Glu Ser Ala
Glu Ala Phe Pro Leu Glu Phe
  Type
Peptide
Class
Hormonal agent
 DG01629  Adrenocorticotropic hormone (ACTH)
Remark
Same as: C02017
ATC code: H01AA01
Chemical structure group: DG00492
Product (DG00492): D00146<US>
Efficacy
Diagnostic (adrenocortical insufficiency), Melanocortin 2 receptor agonist
  Disease
Multiple sclerosis [DS:H01490]
Psoriatic arthritis [DS:H01656]
Rheumatoid arthritis [DS:H00630]
Juvenile rheumatoid arthritis [DS:H01672]
Ankylosing spondylitis [DS:H01674]
Systemic lupus erythematosus [DS:H00080]
Systemic dermatomyositis, polymyositis [DS:H01604]
Erythema multiforme [DS:H01695]
Stevens-Johnson syndrome [DS:H01694]
Optic neuritis [DS:H01717]
Nephrotic syndrome [DS:H01657]
Comment
Glucocorticoid
Adrenocorticotropic hormone (ACTH)
Target
MC2R [HSA:4158] [KO:K04200]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AA ACTH
     H01AA01 Corticotropin
      D00146  Corticotropin (USP/INN) <US>
USP drug classification [BR:br08302]
 Hormonal Agents, Stimulant/Replacement/Modifying (Adrenal)
  Corticotropin
   D00146  Corticotropin (USP/INN)
Drug groups [BR:br08330]
 Hormonal agent
  DG01629  Adrenocorticotropic hormone (ACTH)
   DG00492  Corticotropin
    D00146  Corticotropin
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Melanocortin
    MC2R
     D00146  Corticotropin (USP/INN) <US>
Drug groups [BR:br08330]
 Hormonal agent
  DG01629  Adrenocorticotropic hormone (ACTH)
   DG00492  Corticotropin
Other DBs
CAS: 9002-60-2
PubChem: 7847214
ChEBI: 3892
NIKKAJI: J388.225J

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