KEGG DRUG: Mitomycin

DRUG: Mitomycin

Entry

D00208                      Drug

Name

Mitomycin (USP/INN);
Mitomycin C (JP18);
MMC;
Jelmyto (TN);
Mitomycin (TN);
Muamycin (TN)

Product

JELMYTO (UroGen Pharma), MITOSOL (Mobius Therapeutics LLC)

Generic

MITOMYCIN (Accord Healthcare), MITOMYCIN (Archis Pharma LLC), MITOMYCIN (Archis Pharma LLC), MITOMYCIN (BluePoint Laboratories), MITOMYCIN (Eugia US LLC), MITOMYCIN (Fresenius Kabi USA), MITOMYCIN (Fresenius Kabi USA), MITOMYCIN (Gland Pharma Limited), MITOMYCIN (Gland Pharma Limited), MITOMYCIN (Hikma Pharmaceuticals USA), MITOMYCIN (Hikma Pharmaceuticals USA), MITOMYCIN (Meitheal Pharmaceuticals), MITOMYCIN (Meitheal Pharmaceuticals), MITOMYCIN (Sagent Pharmaceuticals), MITOMYCIN (Sagent Pharmaceuticals), MUTAMYCIN (Accord BioPharma)

Formula

C15H18N4O5

Exact mass

334.1277

Mol weight

334.3272

Structure

Simcomp

Source

Streptomyces caespitosus [TAX:53502]

Remark

Same as:

C06681

Therapeutic category:

1317 4231

ATC code:

L01DC03

Product:

D00208<JP/US>

Efficacy

Antineoplastic

Disease

Glaucoma [DS:H00612]
Upper tract urothelial cancer [DS:H00022]
Adenocarcinoma of the stomach or pancreas [DS:H00018 H00019]

Comment

DNA synthesis inhibitor

Target

DNA

Interaction

Structure map

map07040

Antineoplastics - alkylating agents

map07042

Antineoplastics - agents from natural products

Brite

Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01D CYTOTOXIC ANTIBIOTICS AND RELATED SUBSTANCES
    L01DC Other cytotoxic antibiotics
     L01DC03 Mitomycin
      D00208  Mitomycin (USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antineoplastics
  Antineoplastics, Other
   Mitomycin
    D00208  Mitomycin (USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1317  Ophthalmic antibiotics
     D00208  Mitomycin (USP/INN); Mitomycin C (JP18)
4  Agents affecting cellular function
  42  Antineoplastics
   423  Antibiotics
    4231  Mytomycin C
     D00208  Mitomycin (USP/INN); Mitomycin C (JP18)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
  D00208  Mitomycin C
  D00208  Mitomycin C for injection

Other DBs

CAS:

50-07-7

PubChem:

ChEBI:

LigandBox:

NIKKAJI:

KCF data

ATOM        24
            1   C1z C    26.7153  -18.5085
            2   N1y N    25.8935  -19.6917
            3   C1y C    28.0734  -18.9398
            4   C1y C    25.8935  -17.3777
            5   C2y C    24.5646  -19.2603
            6   C1x C    26.7445  -20.7467
            7   C1y C    28.0967  -20.3444
            8   N1x N    29.3090  -19.6509
            9   C2y C    24.5646  -17.8557
            10  C1b C    26.3074  -16.0547
            11  C5x C    23.3581  -19.9714
            12  C5x C    23.3581  -17.1213
            13  O7a O    25.3573  -15.0289
            14  C2y C    22.1049  -19.2953
            15  O5x O    23.3581  -21.3645
            16  C2y C    22.0875  -17.8674
            17  O5x O    23.3990  -15.7574
            18  C7a C    25.7537  -13.6360
            19  C1a C    20.8694  -20.0006
            20  N1a N    20.8694  -17.1796
            21  N1a N    27.1700  -13.3270
            22  O6a O    24.8443  -12.5926
            23  O2a O    27.4153  -17.2960
            24  C1a C    28.8400  -16.6662
BOND        27
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     4  10 1 #Up
            10    5  11 1
            11    9  12 1
            12   10  13 1
            13   11  14 1
            14   11  15 2
            15   12  16 1
            16   12  17 2
            17   13  18 1
            18   14  19 1
            19   16  20 1
            20   18  21 1
            21   18  22 2
            22    5   9 2
            23    6   7 1
            24    7   8 1
            25   14  16 2
            26    1  23 1 #Down
            27   23  24 1

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