| Entry |
|
|---|
| Name |
Norfloxacin (JP18/USP/INN);
Noroxin (TN) |
|---|
| Formula |
C16H18FN3O3
|
|---|
| Exact mass |
319.1332
|
|---|
| Mol weight |
319.3308
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
|
|---|
| Remark |
| Product (DG00620): | D00210<JP> |
|
|---|
| Efficacy |
Antibacterial, Nucleic acid biosynthesis inhibitor |
|---|
| Target |
|
|---|
| Metabolism |
Enzyme: CYP1A2 [HSA: 1544]
|
|---|
| Interaction |
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01M QUINOLONE ANTIBACTERIALS
J01MA Fluoroquinolones
J01MA06 Norfloxacin
D00210 Norfloxacin (JP18/USP/INN) <JP>
S SENSORY ORGANS
S01 OPHTHALMOLOGICALS
S01A ANTIINFECTIVES
S01AE Fluoroquinolones
S01AE02 Norfloxacin
D00210 Norfloxacin (JP18/USP/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
13 Agents affecting sensory organs
131 Ophthalmic agents
1319 Others
D00210 Norfloxacin (JP18/USP/INN)
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
624 Synthetic antibacterials
6241 Pyridonecarboxylic acids
D00210 Norfloxacin (JP18/USP/INN)
Drug groups [BR:br08330]
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
DG00620 Norfloxacin
D00210 Norfloxacin
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00620 Norfloxacin
D00210 Norfloxacin
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00620 Norfloxacin
D00210 Norfloxacin
DG02852 CYP3A/CYP3A4 inhibitor
DG00620 Norfloxacin
D00210 Norfloxacin
Drug classes [BR:br08332]
Antibacterial
DG01549 Fluoroquinolone
D00210 Norfloxacin
Antimicrobials [BR:br08307]
Antibacterials
Nucleic acid synthesis inhibitor
Fluoroquinolone
D00210 Norfloxacin (JP18/USP/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00210 Norfloxacin
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00210
Drug groups [BR:br08330]
Antibacterial
DG01550 Quinolone
DG01549 Fluoroquinolone
DG00620 Norfloxacin
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00620 Norfloxacin
Metabolizing enzyme inhibitor
DG01634 CYP1A2 inhibitor
DG00620 Norfloxacin
DG02852 CYP3A/CYP3A4 inhibitor
DG00620 Norfloxacin
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Nucleic acid synthesis inhibitor
Fluoroquinolone
DG00620 Norfloxacin
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 23
1 C8y C 22.6983 -16.5436
2 C8y C 22.6983 -15.1538
3 N4y N 23.9247 -17.2386
4 C8x C 21.4721 -17.2386
5 C8y C 23.9247 -14.4530
6 C8x C 21.4721 -14.4530
7 C8x C 25.1509 -16.5436
8 C1b C 23.9188 -18.6458
9 C8y C 20.2516 -16.5436
10 C8y C 25.1509 -15.1538
11 O5x O 23.9188 -13.0399
12 C8y C 20.2516 -15.1538
13 C1a C 22.7042 -19.3349
14 N1y N 19.0428 -17.2210
15 C6a C 26.3654 -14.4414
16 X F 19.0428 -14.4707
17 C1x C 17.8398 -16.5202
18 C1x C 19.0428 -18.6050
19 O6a O 27.5859 -15.1421
20 O6a O 26.3597 -13.0283
21 C1x C 16.6370 -17.2210
22 C1x C 17.8457 -19.2998
23 N1x N 16.6370 -18.6108
BOND 25
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 1
10 5 11 2
11 6 12 2
12 8 13 1
13 9 14 1
14 10 15 1
15 12 16 1
16 14 17 1
17 14 18 1
18 15 19 1
19 15 20 2
20 17 21 1
21 18 22 1
22 21 23 1
23 7 10 2
24 9 12 1
25 22 23 1
|
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