KEGG   DRUG: Atovaquone
Entry
D00236                      Drug                                   
Name
Atovaquone (JAN/USP/INN);
Mepron (TN)
Product
MEPRON (GlaxoSmithKline LLC)
  Generic
ATOVAQUONE (Abon Pharmaceuticals), ATOVAQUONE (American Health Packaging), ATOVAQUONE (Amneal Pharmaceuticals LLC), ATOVAQUONE (AvPAK), ATOVAQUONE (Bionpharma), ATOVAQUONE (Camber Pharmaceuticals), ATOVAQUONE (Chartwell RX), ATOVAQUONE (Glenmark Pharmaceuticals), ATOVAQUONE (Golden State Medical Supply), ATOVAQUONE (Lupin Pharmaceuticals), ATOVAQUONE (Major Pharmaceuticals), ATOVAQUONE (Northstar Rx LLC), ATOVAQUONE (PAI Holdings), ATOVAQUONE (PAI Holdings), ATOVAQUONE (VistaPharm), ATOVAQUONE ORAL SUSPENSION (KVK-Tech)
Formula
C22H19ClO3
Exact mass
366.1023
Mol weight
366.8375
Structure
Simcomp
Remark
Same as: C06835
Therapeutic category: 6290
ATC code: P01AX06
Product: D00236<JP/US>
Product (mixture): D02472<JP/US>
Efficacy
Antifungal (pneumocystic)
  Disease
Pneumocystis jiroveci pneumonia [DS:H01521]
Comment
Naphthoquinone derivative
Target
Cytochrome b [KO:K00412]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
  P01 ANTIPROTOZOALS
   P01A AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
    P01AX Other agents against amoebiasis and other protozoal diseases
     P01AX06 Atovaquone
      D00236  Atovaquone (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antiparasitics
  Antiprotozoals
   Atovaquone
    D00236  Atovaquone (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   629  Miscellaneous
    6290  Miscellaneous
     D00236  Atovaquone (JAN/USP/INN)
Antimicrobials [BR:br08307]
 Antiparasitics
  Agents against Amebiasis and other antiprotozoals
   Others
    D00236  Atovaquone (JAN/USP/INN) <JP/US>
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00236
Other DBs
CAS: 95233-18-4
PubChem: 7847303
ChEBI: 575568
PDB-CCD: AOQ[PDBj]
LigandBox: D00236
NIKKAJI: J389.528I
KCF data

ATOM        26
            1   C2y C    29.8456  -16.7257
            2   C1y C    31.0510  -17.4304
            3   C5x C    28.6285  -17.4245
            4   C2y C    29.8513  -15.3223
            5   C1x C    31.0510  -18.8338
            6   C1x C    32.2681  -16.7257
            7   C8y C    27.4173  -16.7141
            8   O5x O    28.6226  -18.8221
            9   C5x C    28.6402  -14.6235
            10  O1a O    31.0627  -14.6293
            11  C1x C    32.2681  -19.5267
            12  C1x C    33.4736  -17.4304
            13  C8y C    27.4231  -15.3107
            14  C8x C    26.2176  -17.4188
            15  O5x O    28.6459  -13.2202
            16  C1y C    33.4736  -18.8338
            17  C8x C    26.2176  -14.6176
            18  C8x C    25.0005  -16.7141
            19  C8y C    34.6907  -19.5267
            20  C8x C    25.0005  -15.3107
            21  C8x C    34.6907  -20.9302
            22  C8x C    35.9076  -18.8338
            23  C8x C    35.9076  -21.6348
            24  C8x C    37.1130  -19.5267
            25  C8y C    37.1130  -20.9302
            26  X   Cl   38.3300  -21.6290
BOND        29
            1     2   1 1 #Up
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 1
            9     4  10 1
            10    5  11 1
            11    6  12 1
            12    7  13 1
            13    7  14 2
            14    9  15 2
            15   11  16 1
            16   13  17 2
            17   14  18 1
            18   16  19 1 #Down
            19   17  20 1
            20   19  21 2
            21   19  22 1
            22   21  23 1
            23   22  24 2
            24   23  25 2
            25   25  26 1
            26    9  13 1
            27   12  16 1
            28   18  20 2
            29   24  25 1

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Disease (1)   
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Chemical substance (7)   
   KEGG COMPOUND (1)   
   PubChem (1)   
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