KEGG   DRUG: Cefalexin
Entry
D00263                      Drug                                   
Name
Cefalexin (JP18);
Cephalexin;
Keflex (TN)
Formula
C16H17N3O4S
Exact mass
347.094
Mol weight
347.3889
Structure
Simcomp
Class
Antibacterial
 DG01710  beta-Lactam antibiotic
  DG01714  Cephalosporin skeleton group
   DG01488  Cephem
 DG01774  First-generation cephalosporin
Remark
Same as: C06895
Therapeutic category: 6132
ATC code: J01DB01
Chemical structure group: DG00548
Product (DG00548): D00263<JP> D00906<US>
Efficacy
Antibacterial, Cell wall biosynthesis inhibitor
Target
penicillin binding protein
  Pathway
ko00550  Peptidoglycan biosynthesis
Interaction
Structure map
map07013  Cephalosporins - oral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01D OTHER BETA-LACTAM ANTIBACTERIALS
    J01DB First-generation cephalosporins
     J01DB01 Cefalexin
      D00263  Cefalexin (JP18) <JP>
USP drug classification [BR:br08302]
 Antibacterials
  Beta-lactam, Cephalosporins
   Cephalexin
    D00263  Cefalexin (JP18)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  61  Antibiotics
   613  Acting mainly on gram-positive and gram-negative bacteria
    6132  Cephem antibioitics
     D00263  Cefalexin (JP18)
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00548  Cephalexin
      D00263  Cefalexin
  DG01774  First-generation cephalosporin
   DG00548  Cephalexin
    D00263  Cefalexin
Drug classes [BR:br08332]
 Antibacterial
  DG01488  Cephem
   D00263  Cefalexin
Antimicrobials [BR:br08307]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   First-generation cephalosporin
    D00263  Cefalexin (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00263  Cefalexin
  D00263  Cefalexin capsules
  D00263  Cefalexin combination granules
  D00263  Cefalexin for syrup
Drug groups [BR:br08330]
 Antibacterial
  DG01710  beta-Lactam antibiotic
   DG01714  Cephalosporin skeleton group
    DG01488  Cephem
     DG00548  Cephalexin
  DG01774  First-generation cephalosporin
   DG00548  Cephalexin
Antimicrobials abbreviations [BR:br08327]
 Antibacterials
  Cell wall biosynthesis inhibitor, beta-lactam
   First-generation cephalosporin
    DG00548  Cefalexin
Other DBs
CAS: 15686-71-2
PubChem: 7847329
ChEBI: 3534
LigandBox: D00263
NIKKAJI: J3.133J
KCF data

ATOM        24
            1   C1y C    30.2264  -14.8915
            2   N1y N    30.2264  -16.2906
            3   C2y C    31.4381  -16.9900
            4   C2y C    32.6498  -16.2906
            5   C1x C    32.6498  -14.8915
            6   S2x S    31.4381  -14.1919
            7   C1y C    28.8273  -14.8915
            8   C5x C    28.8273  -16.2906
            9   N1b N    27.6157  -14.1919
            10  C5a C    26.4038  -14.8915
            11  O5a O    26.4038  -16.2906
            12  O5x O    27.6157  -16.9900
            13  C1c C    25.1922  -14.1919
            14  C1a C    33.8801  -17.0012
            15  C6a C    31.4381  -18.3890
            16  O6a O    30.2096  -19.0984
            17  O6a O    32.6328  -19.0789
            18  C8y C    23.9610  -14.9031
            19  C8x C    22.7509  -14.2044
            20  C8x C    21.5407  -14.9031
            21  C8x C    21.5407  -16.3005
            22  C8x C    22.7509  -16.9992
            23  C8x C    23.9610  -16.3005
            24  N1a N    25.1922  -12.7883
BOND        26
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     1   7 1
            8     7   8 1
            9     2   8 1
            10    7   9 1 #Up
            11    9  10 1
            12   10  11 2
            13    8  12 2
            14   10  13 1
            15    4  14 1
            16    3  15 1
            17   15  16 2
            18   15  17 1
            19   13  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26   13  24 1 #Up

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