 | | DRUG: Chlorthalidone | |
| Entry |
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| Name |
Chlorthalidone (USP);
Chlortalidone (JAN/INN);
Hygroton (TN);
Thalitone (TN) |
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| Product |
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| Generic |
CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (A-S Medication Solutions), CHLORTHALIDONE (Ajanta Pharma USA), CHLORTHALIDONE (Alembic Pharmaceuticals Limited), CHLORTHALIDONE (Alembic Pharmaceuticals), CHLORTHALIDONE (American Health Packaging), CHLORTHALIDONE (Amneal Pharmaceuticals LLC), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Aphena Pharma Solutions - Tennessee), CHLORTHALIDONE (Ascend Laboratories), CHLORTHALIDONE (AvPAK), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Bryant Ranch Prepack), CHLORTHALIDONE (Chartwell RX), CHLORTHALIDONE (Direct_Rx), CHLORTHALIDONE (Direct_Rx), CHLORTHALIDONE (Dr. Reddy's Laboratories), CHLORTHALIDONE (Dr. Reddy's Laboratories), CHLORTHALIDONE (JUBILANT CADISTA PHARMACEUTICALS), CHLORTHALIDONE (Lifestar Pharma LLC), CHLORTHALIDONE (Major Pharmaceuticals), CHLORTHALIDONE (Mylan Institutional), CHLORTHALIDONE (Mylan Pharmaceuticals), CHLORTHALIDONE (Nivagen Pharmaceuticals), CHLORTHALIDONE (Northstar Rx LLC.), CHLORTHALIDONE (Northwind Pharmaceuticals), CHLORTHALIDONE (Northwind Pharmaceuticals), CHLORTHALIDONE (Northwind Pharmaceuticals), CHLORTHALIDONE (Northwind Pharmaceuticals), CHLORTHALIDONE (Northwind Pharmaceuticals), CHLORTHALIDONE (NuCare Pharmaceuticals), CHLORTHALIDONE (PD-Rx Pharmaceuticals), CHLORTHALIDONE (PD-Rx Pharmaceuticals), CHLORTHALIDONE (Preferred Pharmaceuticals), CHLORTHALIDONE (Proficient Rx LP), CHLORTHALIDONE (REMEDYREPACK), CHLORTHALIDONE (REMEDYREPACK), CHLORTHALIDONE (RPK Pharmaceuticals), CHLORTHALIDONE (RPK Pharmaceuticals), CHLORTHALIDONE (Rising Pharmaceuticals), CHLORTHALIDONE (Sun Pharmaceutical Industries), CHLORTHALIDONE (TAGI Pharma), CHLORTHALIDONE (Unichem Pharmaceuticals (USA)), CHLORTHALIDONE (Zydus Lifesciences Limited), CHLORTHALIDONE (Zydus Pharmaceuticals USA) |
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| Formula |
C14H11ClN2O4S
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| Exact mass |
338.0128
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| Mol weight |
338.7661
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| Structure |
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| Class |
Cardiovascular agent
DG03231 Antihypertensive
DG02992 Thiazide related diuretic
DG01690 Sulfonamide diuretic
DG02992 Thiazide related diuretic
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| Remark |
| Product (mixture): | D10589<US> D10592<US> |
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| Efficacy |
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor |
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| Disease |
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| Comment |
Sulfonamide derivative
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| Target |
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| Interaction |
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| Structure map |
| map07017 | Sulfonamide derivatives - diuretics |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
C03BA Sulfonamides, plain
C03BA04 Chlortalidone
D00272 Chlorthalidone (USP) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Diuretics, Thiazide
Chlorthalidone
D00272 Chlorthalidone (USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
DG02992 Thiazide related diuretic
D00272 Chlorthalidone
DG01690 Sulfonamide diuretic
DG02992 Thiazide related diuretic
D00272 Chlorthalidone
Drug classes [BR:br08332]
Cardiovascular agent
DG02992 Thiazide related diuretic
D00272 Chlorthalidone
DG03231 Antihypertensive
D00272 Chlorthalidone
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A1 (NKCC2)
D00272 Chlorthalidone (USP) <US>
SLC12A3 (TSC)
D00272 Chlorthalidone (USP) <US>
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| Other DBs |
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| KCF data |
ATOM 22
1 C8x C 7.3500 -17.0800
2 C8x C 7.3500 -18.4800
3 C8x C 8.5624 -19.1800
4 C8x C 9.7749 -18.4800
5 C8y C 9.7749 -17.0800
6 C8y C 8.5624 -16.3800
7 C8x C 12.1997 -18.4800
8 C8y C 12.1997 -17.0800
9 C1z C 10.9873 -16.3800
10 C8x C 13.4122 -19.1800
11 C8y C 14.6246 -18.4800
12 C8y C 14.6246 -17.0800
13 C8x C 13.4122 -16.3800
14 X Cl 15.8411 -19.1823
15 S4a S 15.8411 -16.3777
16 N1a N 17.0535 -15.6777
17 O3c O 15.1370 -15.1579
18 O3c O 16.5367 -17.5827
19 N1x N 10.4862 -15.0106
20 C5x C 9.0239 -15.0042
21 O1a O 12.1997 -15.6800
22 O5x O 8.0160 -14.0147
BOND 24
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 11 14 1
16 12 15 1
17 15 16 1
18 15 17 2
19 15 18 2
20 9 19 1
21 19 20 1
22 20 6 1
23 9 21 1
24 20 22 2
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