 | | DRUG: Clonazepam | |
| Entry |
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| Name |
Clonazepam (JP18/USP/INN);
Klonopin (TN) |
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| Product |
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| Generic |
CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (Accord Healthcare), CLONAZEPAM (Advagen Pharma), CLONAZEPAM (Advanced Rx Pharmacy of Tennessee), CLONAZEPAM (Advanced Rx Pharmacy of Tennessee), CLONAZEPAM (Advanced Rx Pharmacy of Tennessee), CLONAZEPAM (Advanced Rx Pharmacy of Tennessee), CLONAZEPAM (Alembic Pharmaceuticals Limited), CLONAZEPAM (Alembic Pharmaceuticals), CLONAZEPAM (American Health Packaging), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aurobindo Pharma Limited), CLONAZEPAM (AvPAK), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Cardinal Health 107), CLONAZEPAM (Chartwell RX), CLONAZEPAM (Clinical Solutions Wholesale), CLONAZEPAM (DIRECT RX), CLONAZEPAM (DIRECT RX), CLONAZEPAM (Direct_Rx), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (Major Pharmaceuticals), CLONAZEPAM (Medsource Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (Par Pharmaceutical), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Quality Care Products), CLONAZEPAM (Quality Care Products), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (RPK Pharmaceuticals), CLONAZEPAM (Solco Healthcare LLC), CLONAZEPAM (Sun Pharmaceutical Industries), CLONAZEPAM (Teva Pharmaceuticals USA), CLONAZEPAM (Teva Pharmaceuticals USA) |
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| Formula |
C15H10ClN3O3
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| Exact mass |
315.0411
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| Mol weight |
315.7112
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
DG03199 Antiepileptic agent
DG02036 Benzodiazepine derivative, antiepileptic
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| Remark |
| Therapeutic category: | 1139 |
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| Efficacy |
Anticonvulsant, Antiepileptic |
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| Disease |
Lennox-Gastaut syndrome [DS: H01813] Panic disorder [DS: H01664] |
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| Comment |
Benzodiazepine derivative
Cytochrome P-450 including CYP3A, may play an important role in clonazepam reduction and oxidation.
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Interaction |
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| Structure map |
| map07230 | GABA-A receptor agonists/antagonists |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N03 ANTIEPILEPTICS
N03A ANTIEPILEPTICS
N03AE Benzodiazepine derivatives
N03AE01 Clonazepam
D00280 Clonazepam (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Anticonvulsants
Gamma-aminobutyric Acid (GABA) Augmenting Agents
Benzodiazepines
Clonazepam
D00280 Clonazepam (JP18/USP/INN)
Anxiolytics
Benzodiazepines
Clonazepam
D00280 Clonazepam (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
113 Antiepileptics
1139 Others
D00280 Clonazepam (JP18/USP/INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01567 GABA-A receptor agonist
D00280 Clonazepam
DG03199 Antiepileptic agent
DG02036 Benzodiazepine derivative, antiepileptic
D00280 Clonazepam
Drug classes [BR:br08332]
Neuropsychiatric agent
DG03199 Antiepileptic agent
D00280 Clonazepam
Target-based classification of drugs [BR:br08310]
Ion channels
Ligand-gated ion channels
GABA (ionotropic)
GABR
D00280 Clonazepam (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00280 Clonazepam
D00280 Clonazepam tablets
D00280 Clonazepam fine granules
Narcotics and psychotropics in Japan [br08308.html]
Psychotropics by Cabinet order Article 3 (78 substances)
D00280
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| Other DBs |
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| KCF data |
ATOM 22
1 C2y C 18.3334 -14.2894
2 C8y C 17.4913 -13.1798
3 C8y C 17.8265 -11.8230
4 N1x N 19.0875 -11.2449
5 N2x N 19.7392 -14.3146
6 C5x C 20.3411 -11.8672
7 C1x C 20.6276 -13.2359
8 C8x C 16.8194 -10.8546
9 C8x C 15.4774 -11.2427
10 C8y C 15.1422 -12.5995
11 C8x C 16.1493 -13.5676
12 N2b N 13.7774 -12.9939 #+
13 C8y C 17.6989 -15.5391
14 C8x C 16.2973 -15.5391
15 O5x O 21.4503 -11.0095
16 C8x C 15.5973 -16.7516
17 C8x C 16.2973 -17.9640
18 C8x C 17.6989 -17.9640
19 C8y C 18.3989 -16.7516
20 X Cl 19.8098 -16.7517
21 O3a O 12.6477 -11.9025 #-
22 O3a O 13.4361 -14.3745
BOND 24
1 3 4 1
2 1 5 2
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 10 12 1
14 1 13 1
15 13 14 1
16 6 15 2
17 14 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 13 19 2
22 19 20 1
23 12 21 1
24 12 22 2
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