| Entry |
|
|---|
| Name |
Clotrimazole (JP18/USP/INN);
Lotrimin (TN);
Mycelex (TN) |
|---|
| Abbr |
CLT |
|---|
| Product |
|
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| Generic |
CLOTRIMAZOLE (A-S Medication Solutions), CLOTRIMAZOLE (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLOTRIMAZOLE (Glenmark Pharmaceuticals), CLOTRIMAZOLE (Hikma Pharmacuticals USA USA), CLOTRIMAZOLE (Novitium Pharma LLC), CLOTRIMAZOLE (NuCare Pharmaceuticals), CLOTRIMAZOLE (Padagis US LLC), CLOTRIMAZOLE (Proficient Rx LP), CLOTRIMAZOLE (REMEDYREPACK), CLOTRIMAZOLE (RPK Pharmaceuticals), CLOTRIMAZOLE (Taro Pharmaceuticals U.S.A.), CLOTRIMAZOLE (Taro Pharmaceuticals U.S.A.), CLOTRIMAZOLE TOPICAL SOLUTION USP, 1% (Bryant Ranch Prepack), CLOTRIMAZOLE TOPICAL SOLUTION USP, 1% (ScieGen Pharmaceuticals), CLOTRIMAZOLE TOPICAL SOLUTION USP, 1% (Tasman Pharma), CLOTRIMAZOLE TOPICAL SOLUTION USP, 1% (TruPharma LLC) |
|---|
| Formula |
C22H17ClN2
|
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| Exact mass |
344.108
|
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| Mol weight |
344.8368
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Antifungal
DG01883 Imidazole antifungal
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
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| Remark |
| Product (mixture): | D10300<US> |
|
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| Efficacy |
Antifungal, Ergosterol biosynthesis inhibitor |
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| Disease |
|
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| Comment |
Imidazole derivative
|
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| Target |
sterol 14alpha-demethylase [KO: K05917] |
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| Pathway |
|
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| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
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| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AB Antiinfectives and antiseptics for local oral treatment
A01AB18 Clotrimazole
D00282 Clotrimazole (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D01 ANTIFUNGALS FOR DERMATOLOGICAL USE
D01A ANTIFUNGALS FOR TOPICAL USE
D01AC Imidazole and triazole derivatives
D01AC01 Clotrimazole
D00282 Clotrimazole (JP18/USP/INN) <JP/US>
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AF Imidazole derivatives
G01AF02 Clotrimazole
D00282 Clotrimazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Dermatological Agents
Topical Anti-infectives
Antifungals, dermatological
Clotrimazole
D00282 Clotrimazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
252 Genital organ agents
2529 Others
D00282 Clotrimazole (JP18/USP/INN)
26 Epidermides
265 Antiparasitic dermatosis agents
2655 Imidazoles
D00282 Clotrimazole (JP18/USP/INN)
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
629 Miscellaneous
6290 Miscellaneous
D00282 Clotrimazole (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Drugs for women
51 Other drugs for women
D00282 Clotrimazole (JP18/USP/INN)
Agents for integumentary system
58 Ringworm drugs
D00282 Clotrimazole (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
First-class OTC drugs
Inorganic and organic chemicals
Clotrimazole
D00282 Clotrimazole (JP18/USP/INN)
Second-class OTC drugs
Inorganic and organic chemicals
Clotrimazole
D00282 Clotrimazole (JP18/USP/INN)
Drug groups [BR:br08330]
Antifungal
DG01883 Imidazole antifungal
D00282 Clotrimazole
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
D00282 Clotrimazole
Drug classes [BR:br08332]
Antifungal
DG01883 Imidazole antifungal
D00282 Clotrimazole
Antimicrobials [BR:br08307]
Antifungals
Ergosterol biosynthesis inhibitor
Imidazole
D00282 Clotrimazole (JP18/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antifungals
Ergosterol biosynthesis inhibitor
Imidazole
D00282 Clotrimazole (JP17/USP/INN)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00282 Clotrimazole
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00282
Rx-to-OTC switch list in the USA [br08315.html]
D00282
Rx-to-OTC switch list in Japan [br08314.html]
D00282
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| Other DBs |
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| KCF data |
ATOM 25
1 C8x C 11.7600 -18.0600
2 C8x C 11.7600 -19.4600
3 C8x C 12.9724 -20.1600
4 C8x C 14.1849 -19.4600
5 C8x C 14.1849 -18.0600
6 C8y C 12.9724 -17.3600
7 C1d C 12.9724 -15.9600
8 C8y C 12.9724 -14.5600
9 C8y C 11.3400 -15.9600
10 N4y N 14.5600 -15.9600
11 C8y C 10.6400 -14.7476
12 C8x C 9.2400 -14.7476
13 C8x C 8.5400 -15.9600
14 C8x C 9.2400 -17.1724
15 C8x C 10.6400 -17.1724
16 C8x C 14.1679 -13.8696
17 C8x C 14.1678 -12.4696
18 C8x C 12.9553 -11.7697
19 C8x C 11.7598 -12.4601
20 C8x C 11.7599 -13.8601
21 C8x C 15.3829 -17.0926
22 N5x N 16.7144 -16.6600
23 C8x C 16.7144 -15.2600
24 C8x C 15.3829 -14.8274
25 X Cl 10.6400 -13.3476
BOND 28
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 6 7 1
8 7 8 1
9 7 9 1
10 7 10 1
11 9 11 2
12 11 12 1
13 12 13 2
14 13 14 1
15 14 15 2
16 9 15 1
17 8 16 2
18 16 17 1
19 17 18 2
20 18 19 1
21 19 20 2
22 8 20 1
23 10 21 1
24 21 22 2
25 22 23 1
26 23 24 2
27 10 24 1
28 11 25 1
|
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