| Entry |
|
|---|
| Name |
Cosyntropin (USP);
Tetracosactide (INN);
Cortrosyn (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C136H210N40O31S
|
|---|
| Exact mass |
2931.5806
|
|---|
| Mol weight |
2933.437
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Sequence |
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys
Arg Arg Pro Val Lys Val Tyr Pro |
|---|
| Type |
Peptide |
|---|
| Class |
Hormonal agent
DG01629 Adrenocorticotropic hormone (ACTH)
|
|---|
| Remark |
| Product (DG00493): | D00284<US> D02105<JP> |
|
|---|
| Efficacy |
Diagnostic (adrenocortical function), Melanocortin 2 receptor agonist |
|---|
| Comment |
syntheses drenocorticotropic hormone (ACTH)
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04925 | Aldosterone synthesis and secretion |
| hsa04927 | Cortisol synthesis and secretion |
|
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| Interaction |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
H01AA ACTH
H01AA02 Tetracosactide
D00284 Cosyntropin (USP) <US>
Drug groups [BR:br08330]
Hormonal agent
DG01629 Adrenocorticotropic hormone (ACTH)
DG00493 Tetracosactide
D00284 Cosyntropin
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Melanocortin
MC2R
D00284 Cosyntropin (USP) <US>
Drug groups [BR:br08330]
Hormonal agent
DG01629 Adrenocorticotropic hormone (ACTH)
DG00493 Tetracosactide
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 208
1 C8y C 31.4015 -47.5464
2 C8y C 30.9959 -46.2317
3 C8y C 32.7545 -47.5464
4 C8x C 30.7014 -48.7173
5 C1b C 29.4651 -46.2317
6 C8x C 32.1072 -45.4080
7 N4x N 33.2126 -46.2317
8 C8x C 33.4417 -48.7500
9 C8x C 31.3816 -49.9666
10 C1c C 28.2290 -45.5974
11 C8x C 32.7417 -49.9666
12 N1b N 28.2290 -44.2243
13 C5a C 27.0978 -46.4083
14 C5a C 29.3168 -43.4460
15 N1b N 27.1106 -47.8211
16 O5a O 25.8814 -45.7609
17 C1c C 29.3472 -42.0660
18 O5a O 30.5835 -44.0538
19 C1b C 25.9737 -48.5793
20 N1b N 30.4351 -41.2480
21 C1b C 28.1308 -41.4188
22 C5a C 24.6674 -47.9062
23 C5a C 30.4597 -39.8552
24 C1b C 28.1308 -40.0188
25 N1b N 24.6392 -46.5193
26 O5a O 23.6448 -48.7956
27 C1c C 31.6434 -39.0968
28 O5a O 29.2630 -39.2535
29 C1b C 26.9085 -39.3714
30 C1c C 23.4484 -45.8719
31 N1b N 31.5978 -37.7041
32 C1b C 32.8398 -39.7243
33 N1b N 26.8758 -37.9786
34 C5a C 23.4228 -44.4662
35 C1b C 22.2845 -46.6374
36 C5a C 32.7545 -36.9187
37 C8y C 32.8225 -41.1371
38 C2c C 25.6791 -37.3639
39 N1y N 22.2320 -43.8190
40 O5a O 24.6193 -43.7007
41 C1b C 21.0740 -46.0355
42 C1c C 32.7358 -35.4802
43 O5a O 33.9711 -37.5602
44 C8x C 31.7017 -41.8896
45 C8x C 34.0890 -41.7587
46 N1a N 25.6896 -35.9511
47 N2a N 24.5014 -38.1294
48 C1y C 22.0556 -42.4390
49 C1x C 20.9758 -44.4990
50 C1b C 19.9172 -46.7811
51 C1b C 31.6434 -34.9311
52 N1b N 33.8729 -34.7348
53 C8x C 31.6842 -43.3082
54 C8x C 34.0775 -43.1517
55 C1x C 20.6955 -42.2624
56 C5a C 23.0500 -41.6080
57 C1x C 20.0352 -43.4787
58 C1b C 18.7207 -46.1536
59 C8y C 30.3813 -35.5259
60 C5a C 33.8729 -33.3476
61 C8x C 32.9508 -43.9497
62 N1b N 23.0338 -40.1298
63 O5a O 24.3646 -42.2624
64 N1a N 17.5427 -46.8919
65 C8x C 30.1324 -36.9386
66 N5x N 29.1124 -34.8786
67 C1c C 35.0108 -32.5892
68 O5a O 32.6435 -32.7201
69 C1c C 21.9073 -39.4826
70 N4x N 28.7197 -37.1350
71 C8x C 28.0922 -35.8729
72 N1b N 34.9911 -31.1708
73 C1b C 36.2473 -33.2309
74 C5a C 21.9178 -38.0896
75 C1c C 20.7996 -40.2935
76 C5a C 36.1491 -30.4054
77 C1b C 36.2473 -34.6238
78 N1b N 20.7410 -37.4621
79 O5a O 23.1284 -37.3312
80 C1a C 20.7690 -41.6806
81 C1a C 19.5830 -39.6460
82 C1c C 36.1233 -29.0183
83 O5a O 37.3456 -31.0528
84 C6a C 37.4637 -35.2314
85 C1b C 20.7014 -36.0493
86 N1b N 37.2172 -28.2471
87 C1b C 34.8428 -28.3908
88 O6a O 37.4463 -36.6441
89 O6a O 38.6345 -34.4601
90 C5a C 19.5245 -35.4021
91 C5a C 37.2417 -26.8473
92 C1b C 34.8742 -26.9980
93 N1b N 19.5047 -33.9893
94 O5a O 18.3479 -36.1534
95 C1c C 38.3857 -26.0759
96 O5a O 36.0251 -26.2127
97 S2a S 33.6836 -26.3705
98 C1c C 20.6255 -33.2368
99 N1b N 38.3599 -24.7332
100 C1b C 39.6219 -26.7035
101 C1a C 32.4613 -27.4035
102 C5a C 20.6628 -31.8438
103 C1b C 21.8991 -33.8981
104 C5a C 39.4667 -23.8980
105 O1a O 39.6348 -28.0965
106 N1b N 21.8196 -31.0726
107 O5a O 19.4661 -31.1966
108 C1b C 23.0500 -33.1327
109 C1c C 39.4982 -22.5050
110 O5a O 40.7531 -24.5453
111 C1c C 21.8137 -29.6598
112 C1b C 24.2467 -33.7204
113 C1b C 40.6549 -21.7466
114 N1b N 38.2817 -21.8377
115 C5a C 22.9518 -28.8945
116 C1b C 20.6032 -29.0780
117 C1b C 25.4045 -32.9622
118 C8y C 40.6421 -20.3538
119 C5a C 37.1108 -22.6489
120 N1b N 22.9518 -27.5273
121 O5a O 24.1682 -29.5617
122 C1b C 19.4464 -29.8036
123 N1a N 26.6209 -33.6035
124 C8x C 39.3300 -19.7123
125 C8x C 41.7930 -19.5685
126 C1c C 35.9072 -22.0214
127 O5a O 37.0735 -23.7616
128 C1c C 24.0584 -26.7819
129 C1b C 18.2497 -29.1890
130 C8x C 39.3602 -18.2995
131 C8x C 41.7733 -18.1558
132 C1b C 34.7364 -22.7797
133 N1a N 35.9445 -20.6284
134 C5a C 24.0899 -25.3562
135 C1b C 25.3321 -27.4035
136 C1b C 17.0333 -29.9345
137 C8y C 40.5569 -17.5283
138 O1a O 34.6863 -24.2906
139 N1b N 25.2363 -24.6107
140 O5a O 22.9191 -24.7217
141 C1b C 26.5030 -26.6451
142 N1a N 15.8753 -29.2872
143 O1a O 40.4984 -16.1155
144 C1c C 25.2667 -23.2177
145 C1b C 27.6997 -27.2726
146 C5a C 24.0700 -22.5835
147 C1b C 26.4632 -22.4526
148 N1b N 28.8703 -26.5071
149 N1y N 24.1075 -21.1776
150 O5a O 22.8536 -23.3486
151 C1b C 27.6598 -23.0742
152 C2c C 30.0869 -27.1161
153 C1y C 24.6976 -19.8830
154 C1x C 22.6772 -20.9614
155 C1b C 28.7978 -22.3087
156 N1a N 31.2248 -26.3764
157 N2a N 30.1066 -28.5217
158 C1x C 23.7430 -18.9410
159 C5a C 25.8755 -19.1175
160 C1x C 22.5067 -19.5685
161 N1b N 30.0085 -22.9561
162 N1b N 25.9057 -17.7505
163 O5a O 27.0919 -19.7848
164 C2c C 31.1852 -22.1977
165 C1c C 26.9237 -16.9652
166 N1a N 32.3888 -22.7797
167 N2a N 31.2167 -20.7849
168 C5a C 26.9740 -15.5466
169 C1c C 28.2290 -17.6066
170 N1b N 28.0608 -14.7882
171 O5a O 25.7576 -14.9447
172 C1a C 29.3868 -16.8412
173 C1a C 28.2290 -19.0193
174 C1c C 28.0922 -13.3754
175 C5a C 29.2688 -12.6357
176 C1b C 26.8957 -12.7865
177 N1b N 29.2303 -11.2171
178 O5a O 30.5051 -13.2971
179 C1b C 25.7048 -13.5718
180 C1c C 30.4069 -10.4717
181 C1b C 24.4686 -12.9044
182 C5a C 30.3615 -9.1576
183 C1c C 31.6761 -11.1189
184 C1b C 23.2919 -13.6699
185 N1b N 29.0223 -8.4353
186 O5a O 31.5779 -8.4130
187 C1a C 31.7215 -12.5703
188 C1a C 32.8726 -10.3735
189 N1a N 22.0556 -13.0026
190 C1c C 29.0667 -7.0003
191 C5a C 30.2387 -6.1570
192 C1b C 27.7580 -6.2559
193 N1y N 30.2633 -4.7514
194 O5a O 31.6175 -6.9016
195 C8y C 26.4831 -7.0988
196 C1y C 31.5978 -4.0832
197 C1x C 29.2630 -3.6122
198 C8x C 25.1884 -6.3390
199 C8x C 26.4715 -8.5340
200 C1x C 31.3816 -2.5718
201 C6a C 32.9124 -4.7514
202 C1x C 29.9103 -2.3427
203 C8x C 23.9393 -7.1212
204 C8x C 25.3063 -9.3162
205 O6a O 34.1672 -3.9459
206 O6a O 32.9007 -6.2559
207 C8y C 23.9218 -8.6866
208 O1a O 22.7357 -9.3772
BOND 216
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 2
6 3 7 1
7 3 8 1
8 4 9 2
9 10 5 1 #Up
10 8 11 2
11 10 12 1
12 10 13 1
13 12 14 1
14 13 15 1
15 13 16 2
16 14 17 1
17 14 18 2
18 15 19 1
19 17 20 1
20 17 21 1 #Down
21 19 22 1
22 20 23 1
23 21 24 1
24 22 25 1
25 22 26 2
26 23 27 1
27 23 28 2
28 24 29 1
29 25 30 1
30 27 31 1
31 27 32 1 #Up
32 29 33 1
33 30 34 1
34 30 35 1 #Up
35 31 36 1
36 32 37 1
37 33 38 1
38 34 39 1
39 34 40 2
40 35 41 1
41 36 42 1
42 36 43 2
43 37 44 2
44 37 45 1
45 38 46 1
46 38 47 2
47 39 48 1
48 39 49 1
49 41 50 1
50 42 51 1 #Down
51 42 52 1
52 44 53 1
53 45 54 2
54 48 55 1
55 48 56 1 #Up
56 49 57 1
57 50 58 1
58 51 59 1
59 52 60 1
60 53 61 2
61 56 62 1
62 56 63 2
63 58 64 1
64 59 65 2
65 59 66 1
66 60 67 1
67 60 68 2
68 62 69 1
69 65 70 1
70 66 71 2
71 67 72 1
72 67 73 1 #Up
73 69 74 1
74 69 75 1 #Up
75 72 76 1
76 73 77 1
77 74 78 1
78 74 79 2
79 75 80 1
80 75 81 1
81 76 82 1
82 76 83 2
83 77 84 1
84 78 85 1
85 82 86 1
86 82 87 1 #Down
87 84 88 1
88 84 89 2
89 85 90 1
90 86 91 1
91 87 92 1
92 90 93 1
93 90 94 2
94 91 95 1
95 91 96 2
96 92 97 1
97 93 98 1
98 95 99 1
99 95 100 1 #Up
100 97 101 1
101 98 102 1
102 98 103 1 #Up
103 99 104 1
104 100 105 1
105 102 106 1
106 102 107 2
107 103 108 1
108 104 109 1
109 104 110 2
110 106 111 1
111 108 112 1
112 109 113 1
113 109 114 1 #Up
114 111 115 1
115 111 116 1 #Down
116 112 117 1
117 113 118 1
118 114 119 1
119 115 120 1
120 115 121 2
121 116 122 1
122 117 123 1
123 118 124 1
124 118 125 2
125 119 126 1
126 119 127 2
127 120 128 1
128 122 129 1
129 124 130 2
130 125 131 1
131 126 132 1
132 126 133 1
133 128 134 1
134 128 135 1 #Up
135 129 136 1
136 130 137 1
137 132 138 1
138 134 139 1
139 134 140 2
140 135 141 1
141 136 142 1
142 137 143 1
143 139 144 1
144 141 145 1
145 144 146 1
146 144 147 1 #Up
147 145 148 1
148 146 149 1
149 146 150 2
150 147 151 1
151 148 152 1
152 149 153 1
153 149 154 1
154 151 155 1
155 152 156 1
156 152 157 2
157 153 158 1
158 153 159 1 #Up
159 154 160 1
160 155 161 1
161 159 162 1
162 159 163 2
163 161 164 1
164 162 165 1
165 164 166 1
166 164 167 2
167 165 168 1
168 165 169 1 #Down
169 168 170 1
170 168 171 2
171 169 172 1
172 169 173 1
173 170 174 1
174 174 175 1
175 174 176 1 #Up
176 175 177 1
177 175 178 2
178 176 179 1
179 177 180 1
180 179 181 1
181 180 182 1
182 180 183 1 #Down
183 181 184 1
184 182 185 1
185 182 186 2
186 183 187 1
187 183 188 1
188 184 189 1
189 185 190 1
190 190 191 1
191 190 192 1 #Up
192 191 193 1
193 191 194 2
194 192 195 1
195 193 196 1
196 193 197 1
197 195 198 2
198 195 199 1
199 196 200 1
200 196 201 1 #Up
201 197 202 1
202 198 203 1
203 199 204 2
204 201 205 1
205 201 206 2
206 203 207 2
207 207 208 1
208 6 7 1
209 9 11 1
210 54 61 1
211 55 57 1
212 70 71 1
213 131 137 2
214 158 160 1
215 200 202 1
216 204 207 1
|
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