 | | DRUG: Co-Trimoxazole | |
| Entry |
|
|---|
| Name |
Co-Trimoxazole (BAN);
Sulfamethoxazole and trimethoprim;
Bactrim (TN);
Septra (TN) |
|---|
| Abbr |
SXT |
|---|
| Product |
|
|---|
| Generic |
SULFAMETH/TRIMETH-DS (DIRECT RX), SULFAMETH/TRIMETH-DS (DirectRX), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETH/TRIMETH-DS (Direct_Rx), SULFAMETHOX-TMP DS (PharmPak), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (A-S Medication Solutions), SULFAMETHOXAZOLE AND TRIMETHOPRIM (ANI Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Advanced Rx Pharmacy of Tennessee), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Advanced Rx Pharmacy of Tennessee), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Advanced Rx Pharmacy of Tennessee), SULFAMETHOXAZOLE AND TRIMETHOPRIM (American Health Packaging), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Amneal Pharmaceuticals LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Amneal Pharmaceuticals of New York LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Asclemed USA), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Aurobindo Pharma Limited), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Aurobindo Pharma Limited), SULFAMETHOXAZOLE AND TRIMETHOPRIM (AvKARE), SULFAMETHOXAZOLE AND TRIMETHOPRIM (AvPAK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Bryant Ranch Prepack), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Bryant Ranch Prepack), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Cardinal Health 107), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Chartwell RX), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Chartwell RX), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Cronus Pharma LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Denton Pharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Denton Pharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Golden State Medical Supply), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Lannett Company), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Major Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Medsource Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Mylan Institutional LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Mylan Institutional LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NCS HealthCare of KY), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Northwind Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Northwind Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (NuCare Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (PD-Rx Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Pharmasource Meds), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Prasco Laboratories), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Preferred Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Preferred Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Proficient Rx LP), SULFAMETHOXAZOLE AND TRIMETHOPRIM (QPharma), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Quality Care Products LLC), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (REMEDYREPACK), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RPK Pharmaceuticals), SULFAMETHOXAZOLE AND TRIMETHOPRIM (RedPharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Redpharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Redpharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Redpharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Redpharm Drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Redpharm drug), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Rising Health), SULFAMETHOXAZOLE AND TRIMETHOPRIM (ST. MARY'S MEDICAL PARK PHARMACY), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Somerset Therapeutics), SULFAMETHOXAZOLE AND TRIMETHOPRIM (St. Mary's Medical Park Pharmacy), SULFAMETHOXAZOLE AND TRIMETHOPRIM (St. Mary's Medical Park Pharmacy), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Sun Pharmaceutical Industries), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Teva Parenteral Medicines), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Teva Parenteral Medicines), SULFAMETHOXAZOLE AND TRIMETHOPRIM (Vista Pharmaceuticals) |
|---|
| Formula |
C14H18N4O3. C10H11N3O3S
|
|---|
| Exact mass |
543.19
|
|---|
| Mol weight |
543.5954
|
|---|
| Structure |
|
|---|
| Component |
|
|---|
| Class |
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
DG01643 CYP2C9 inhibitor
Transporter inhibitor
DG02863 SLC22A2 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antibacterial |
|---|
| Disease |
Shigellosis [DS: H00299] Pneumocystis jiroveci pneumonia [DS: H01521] |
|---|
| Comment |
Sulfamethoxazole is an inhibitor of CYP2C9.
Trimethoprim is an inhibitor of CYP2C8 as well as OCT2 transporter.
|
|---|
| Interaction |
CYP inhibition: CYP2C8 [HSA: 1558], CYP2C9 [HSA: 1559]
Transporter inhibition: SLC22A2 [HSA: 6582]
|
|---|
| Structure map |
| map07016 | Sulfonamide derivatives - sulfa drugs |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01E SULFONAMIDES AND TRIMETHOPRIM
J01EE Combinations of sulfonamides and trimethoprim, incl. derivatives
J01EE01 Sulfamethoxazole and trimethoprim
D00285 Co-Trimoxazole (BAN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Sulfamethoxazole/ Trimethoprim
D00285 Co-Trimoxazole (BAN)
Therapeutic category of drugs in Japan [BR:br08301]
6 Agents against pathologic organisms and parasites
62 Chemotherapeutics
629 Miscellaneous
6290 Miscellaneous
D00285 Co-Trimoxazole (BAN)
64 Parasitics (systemic)
641 Antiprotozoans
6419 Others
D00285 Co-Trimoxazole (BAN)
Drug groups [BR:br08330]
Metabolizing enzyme inhibitor
DG01641 CYP2C8 inhibitor
D00285 Co-Trimoxazole
DG01643 CYP2C9 inhibitor
D00285 Co-Trimoxazole
Transporter inhibitor
DG02863 SLC22A2 inhibitor
D00285 Co-Trimoxazole
Antimicrobials [BR:br08307]
Antibacterials
Folic acid biosynthesis inhibitor
Intermediate-acting sulfonamide
D00285 Co-Trimoxazole (BAN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Folic acid biosynthesis inhibitor
Intermediate-acting sulfonamide
D00285 Co-Trimoxazole (BAN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00285
Drug transporters
D00285
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00285
|
|---|
| Other DBs |
|
|---|
| KCF data |
ATOM 38
1 C8y C 17.7985 -15.4832
2 C8x C 16.6120 -16.2509
3 C8x C 17.7985 -14.0874
4 C1b C 18.9850 -16.1811
5 C8y C 15.3558 -15.5530
6 C8y C 16.5422 -13.4593
7 C8y C 20.1714 -15.4832
8 C8y C 15.3558 -14.1572
9 O2a O 14.1694 -16.2509
10 O2a O 16.5422 -12.0635
11 C8y C 21.4276 -16.1113
12 C8x C 20.1714 -14.0176
13 O2a O 14.0996 -13.4593
14 C1a C 12.9132 -15.6228
15 N5x N 22.6140 -15.4134
16 N1a N 21.4276 -17.5072
17 N5x N 21.3578 -13.3197
18 C8y C 22.6140 -14.0176
19 N1a N 23.8005 -13.2499
20 C1a C 14.0525 -12.0643
21 C1a C 17.7452 -11.3556
22 C8y C 32.5183 -13.0378
23 N1b N 31.3319 -13.7357
24 N5x N 32.5678 -11.7075
25 C8x C 33.8111 -13.5108
26 S4a S 30.1453 -13.0378
27 O2x O 33.9412 -11.3333
28 C8y C 34.7188 -12.4690
29 C8y C 28.9589 -13.7357
30 O3c O 28.9589 -12.0608
31 O3c O 31.4016 -12.0608
32 C1a C 36.0513 -12.4473
33 C8x C 28.9589 -15.1315
34 C8x C 27.7725 -13.0378
35 C8x C 27.7725 -15.8294
36 C8x C 26.5861 -13.7357
37 C8y C 26.5861 -15.1315
38 N1a N 25.3996 -15.8294
BOND 40
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 3 6 2
6 4 7 1
7 5 8 2
8 5 9 1
9 6 10 1
10 7 11 2
11 7 12 1
12 8 13 1
13 9 14 1
14 11 15 1
15 11 16 1
16 12 17 2
17 15 18 2
18 18 19 1
19 6 8 1
20 17 18 1
21 13 20 1
22 10 21 1
23 22 23 1
24 22 24 2
25 22 25 1
26 23 26 1
27 24 27 1
28 25 28 2
29 26 29 1
30 26 30 2
31 26 31 2
32 28 32 1
33 29 33 1
34 29 34 2
35 33 35 2
36 34 36 1
37 35 37 1
38 37 38 1
39 27 28 1
40 36 37 2
|
|---|
|
» Japanese version » Back
|
|